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01-05-2014 | Functional Neuroradiology

Motor function deficits in schizophrenia: an fMRI and VBM study

Authors: Sadhana Singh, Satnam Goyal, Shilpi Modi, Pawan Kumar, Namita Singh, Triptish Bhatia, Smita N. Deshpande, Subash Khushu

Published in: Neuroradiology | Issue 5/2014

Abstract

Introduction

To investigate whether the motor functional alterations in schizophrenia (SZ) are also associated with structural changes in the related brain areas using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM).

Methods

A sample of 14 right-handed SZ patients and 14 right-handed healthy control subjects matched for age, sex, and education were examined with structural high-resolution T1-weighted MRI; fMRI images were obtained during right index finger-tapping task in the same session.

Results

fMRI results showed reduced functional activation in the motor areas (contralateral precentral and postcentral gyrus) and ipsilateral cerebellum in SZ subjects as compared to healthy controls (n = 14). VBM analysis also revealed reduced grey matter in motor areas and white matter reduction in cerebellum of SZ subjects as compared to controls.

Conclusion

The present study provides an evidence for a possible association between structural alterations in the motor cortex and disturbed functional activation in the motor areas in persons affected with SZ during a simple finger-tapping task.

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http://www.fil.ion.ucl.ac.uk/~john/misc/VBMclass10.pdf

http://www.jiscmail.ac.uk/cgi-bin/wa.exe?A2=ind0807&L=SPM&P=R7075&1

Mueller S, Keeser D, Reiser MF, Teipel S, Meindl T (2011) Functional and structural MR imaging in neuropsychiatric disorders: Part 2. Application in schizophrenia and autism. AJNR Am J Neuroradiol 33:2033–2037. doi:10.3174/ajnr.A2800 PubMedCrossRef

Green MF (1996) What are the functional consequences of neurocognitive deficits in schizophrenia. Am J Psychiat 153:321–330PubMed

Rund BR, Borg NE (1999) Cognitive deficits and cognitive training in schizophrenic patients: a review. Acta Psychiat Scand 100:85–95PubMedCrossRef

Penn DL, Spaulding W, Reed D, Sullivan M, Mueser KT, Hope DA (1997) Cognition and social functioning in schizophrenia. Psychiatry 60:281–291PubMed

Karlsgodt KH, Glahn DC, van Erp TGM, Therman S, Huttunen M, Manninen M, Kaprio J, Cohen MS, Lönnqvist J, Cannon TD (2007) The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr Res 89:191–197PubMedCrossRef

Sanjuana J, Lull JJ, Aguilar EJ, Marti-Bonmatí L, Moratal D, Gonzalez JC, Robles M, Keshavan MS (2007) Emotional words induce enhanced brain activity in schizophrenic patients with auditory hallucinations. Psychiat Res 154:21–29CrossRef

Bedford NJ, Surguladze S, Giampietro V, Brammer MJ, David AS (2012) Self-evaluation in schizophrenia: an fMRI study with implications for the understanding of insight. BMC Psychiat 12:106CrossRef

Goldberg TE, Green MF (2002) Neurocognitive functioning in patients with schizophrenia: an overview. In: Davis KL, Charney D, Coyle JT, Nemeroff C (eds) Neuropsychopharmacology—fifth generation of progress. Lippincott, Philadelphia, pp 657–669

Müller JL, Röder CH, Schuierer G, Klein H (2002) Motor-induced brain activation in cortical, subcortical and cerebellar regions in schizophrenic inpatients. A whole brain fMRI fingertapping study. Prog Neuropsychopharmacol Biol Psychiat 26(3):421–426CrossRef

10.

Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K (2008) Impairment of motor dexterity in schizophrenia assessed by a novel finger movement test. Psychiat Res 159:281–289CrossRef

11.

Varlet M, Marin L, Raffard S, Schmidt RC, Capdevielle D, Boulenger JP, Del-Monte J, Bardy BG (2012) Impairments of social motor coordination in schizophrenia. PLoS One 7(1):e29772. doi:10.1371/journal.pone.0029772 PubMedCentralPubMedCrossRef

12.

Fink M, Shorter E, Taylor MA (2010) Catatonia is not schizophrenia: Kraepelin’s error and the need to recognize catatonia as an independent syndrome in medical nomenclature. Schizophr Bull 36:314–320PubMedCentralPubMedCrossRef

13.

Ungvari GS, Caroff SN, Gerevich J (2010) The catatonia conundrum: evidence of psychomotor phenomena as a symptom dimension in psychotic disorders. Schizophr Bull 36:231–238PubMedCentralPubMedCrossRef

14.

Pappa S, Dazzan P (2009) Spontaneous movement disorders in antipsychotic-naive patients with first-episode psychoses: a systematic review. Psychol Med 39:1065–1076PubMedCrossRef

15.

Whitty PF, Owoeye O, Waddington JL (2009) Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology. Schizophr Bull 35:415–424PubMedCentralPubMedCrossRef

16.

Morrens M, Hulstijn W, Sabbe B (2007) Psychomotor slowing in schizophrenia. Schizophr Bull 33:1038–1053PubMedCentralPubMedCrossRef

17.

Wolff AL, O’Driscoll GA (1999) Motor deficits and schizophrenia: the evidence from neuroleptic-naive patients and populations at risk. J Psychiat Neurosci 24:304–314

18.

Torrey EF (2002) Studies of individuals with schizophrenia never treated with antipsychotic medications: a review. Schizophr Res 58:101–115PubMedCrossRef

19.

Walther S, Strik W (2012) Motor symptoms and schizophrenia. Neuropsychobiology 66:77–92PubMedCrossRef

20.

Niznikiewicz MA, Kubicki M, Shenton ME (2003) Recent structural and functional imaging findings in schizophrenia. Curr Opin Psychiat 16:123–147CrossRef

21.

Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, Ugurbil K (1993) Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. Biophys J 64:803–812PubMedCentralPubMedCrossRef

22.

Payoux P, Boulanouar K, Sarramon C, Fabre N, Descombes S, Galitsky M, Thalamas C, Brefel-Courbon C, Sabatini U, Manelfe C, Chollet F, Schmitt L, Rascol O (2004) Cortical motor activation in akinetic schizophrenic patients: a pilot functional MRI study. Mov Disord 19:83–90PubMedCrossRef

23.

Ananth H, Popescu I, Critchley HD, Good CD, Frackowiak RS, Dolan RJ (2002) Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized volumetric voxel based morphometry. Am J Psychiat 159(9):1497–1505PubMedCrossRef

24.

Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, Fukuda R, Ron M, Toone B (2001) Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am J Psychiat 158(2):234–243PubMedCrossRef

25.

Kubicki M, Shenton ME, Salisbury DF, Hirayasu Y, Kasai K, Kikinis R, Jolesz FA, McCarley RW (2002) Voxel-based morphometric analysis of gray matter in first episode schizophrenia. Neuroimage 17(4):1711–1719PubMedCentralPubMedCrossRef

26.

Moorhead TW, Job DE, Whalley HC, Sanderson TL, Johnstone EC, Lawrie SM (2004) Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods. Neuroimage 22(1):188–202PubMedCrossRef

27.

Giuliania NR, Calhouna VD, Pearlsona GD, Francisd A, Buchanan RW (2005) Voxel-based morphometry versus region of interest: a comparison of two methods for analyzing gray matter differences in schizophrenia. Schizophr Res 74:135–147CrossRef

28.

Asami T, Bouix S, Whitford TJ, Shenton ME, Salisbury DF, McCarley RW (2012) Longitudinal loss of gray matter volume in patients with first-episode schizophrenia: DARTEL automated analysis and ROI validation. NeuroImage 59:986–996PubMedCentralPubMedCrossRef

29.

Lui S, Deng W, Huang X, Jiang L, Ma X, Chen H, Zhang T, Li X, Li D, Zou L, Tang H, Zhou XJ, Mechelli A, C ollier DA, Sweeney JA, Li T, Gong Q (2009) Association of cerebral deficits with clinical symptoms in antipsychoticnaive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. Am J Psychiat 166:196–205PubMedCrossRef

30.

Pomarol-Clotet E, Canales-Rodríguez EJ, Salvador R, Sarró S, Gomar JJ, Vila F, Ortiz-Gil J, Iturria-Medina Y, Capdevila A, McKenna PJ (2010) Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Mol Psychiat 15(8):823–830CrossRef

31.

Nurnberger JI Jr, Blehar MC, Kaufmann CA (1994) Diagnostic interview for genetic studies. Rationale, unique features and training. NIHM Genetics Initiative. Arch Gen Psychiat 51:849–859PubMedCrossRef

32.

Deshpande SN, Mathur MN, Das SK, Bhatia T, Sharma S, Nimgaonkar VL (1998) A Hindi version of the diagnostic interview for genetic studies. Schizophr Bull 24:489–493PubMedCrossRef

33.

Gur RC, Ragland JD, Moberg PJ, Bilker WB, Kohler C, Siegel SJ, Gur RE (2001) Computerized neurocognitive scanning: II. The profile of schizophrenia. Neuropsychopharmacology 25:777–788PubMedCrossRef

34.

Worksley KJ, Friston KJ (1995) Analysis of fMRI time-series revisited again. Neuroimage 2:173–181CrossRef

35.

Eickhoff SB, Stephan KE, Mohlberg H (2005) A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. NeuroImage 25(4):1325–1335PubMedCrossRef

36.

Ashburner J, Friston KJ (2000) Voxel-based morphometry—the methods. Neuroimage 11:805–821PubMedCrossRef

37.

Dassonville P, Zhu X-H, Ugurbil K, Kim S-G, Ashe J, (1997) Neurobiology functional activation in motor cortex reflects the direction and the degree of handedness. Proc Natl Acad Sci U S A 94:14015–14018PubMedCentralPubMedCrossRef

38.

Jogems-Kostermana BJM, Zitmanb FG, Van Hoofa JJM, Hulstijnc W (2001) Psychomotor slowing and planning deficits in schizophrenia. Schizophr Res 48:317–333CrossRef

39.

Cramer SC, Moore CI, Finklestein SP, Rosen BR (2000) A pilot study of somatotopic mapping after cortical infarct. Stroke 31:668–671PubMedCrossRef

40.

Picard H, Amado I, Mages SM, Olie JP, Krebs MO (2008) The role of the cerebellum in schizophrenia: an update of clinical, cognitive, and functional evidences. Schizophr Bull 34:155–172PubMedCentralPubMedCrossRef

41.

Schamhmann J (1998) Dysmetria of thought: clinical consequences of cerebellar dysfunction on cognition and affect. Trends Cogn Sci 2:362–371CrossRef

42.

Marcelis M, Suckling J, Woodruff P, Hofman P, Bullmore E, van Os J (2003) Searching for a structural endophenotype in psychosis using computational morphometry. Psychiat Res 122:153–167CrossRef

43.

Salgado-Pineda P, Baeza I, Perez-Gomez M, Vendrell P, Junque C, Bargallo N, Bernardo M (2003) Sustained attention impairment correlates to gray matter decreases in first episode neuroleptic naive schizophrenic patients. Neuroimage 19:365–375PubMedCrossRef

44.

Reichenberg A (2010) The assessment of neuropsychological functioning in schizophrenia. Dialogues Clin Neurosci 12:383–392PubMed

45.

Chan RC, Chen EY, Law CW (2006) Specific executive dysfunction in patients with first-episode medication-naive schizophrenia. Schizophr Res 82(1):51–64PubMedCrossRef

46.

Joyce E, Hutton S, Mutsatsa S, Gibbins H, Webb E, Paul S, Robbins T, Barnes T (2002) Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: and relationship to duration of untreated psychosis: the West London Study. Br J Psychiat 181:s38–s44CrossRef

47.

Muller U, Werheid K, Hammerstein E, Jungmann S, Becker T (2005) Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics. Eur Psychiat 20:70–73CrossRef

48.

Putzhammer A, Heindle B, Broll K, Pfeiff L, Perfahl M, Hajak G (2004) Spatial and temporal parameters of gait disturbances in schizophrenic patients. Schizophr Res 69:159–166PubMedCrossRef

49.

Putzhammer A, Perfahl M, Pfeiff L, Ibach B, Johann M, Zitzelsberger U, Hajak G (2005) Performance of diadochokinetic movements in schizophrenic patients. Schizophr Res 79:271–280PubMedCrossRef

50.

Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, Gur RC (1994) Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch Gen Psychiat 51:124–131PubMedCrossRef

Title: Motor function deficits in schizophrenia: an fMRI and VBM study
Authors: Sadhana Singh
Satnam Goyal
Shilpi Modi
Pawan Kumar
Namita Singh
Triptish Bhatia
Smita N. Deshpande
Subash Khushu
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 5/2014
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-014-1325-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Motor function deficits in schizophrenia: an fMRI and VBM study

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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