Top

Published in:

01-09-2012 | Diagnostic Neuroradiology

Significance of apparent diffusion coefficient measurement for the differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and Parkinson's disease: evaluation by 3.0-T MR imaging

Authors: Kazumichi Tsukamoto, Eiji Matsusue, Yoshiko Kanasaki, Suguru Kakite, Shinya Fujii, Toshio Kaminou, Toshihide Ogawa

Published in: Neuroradiology | Issue 9/2012

Abstract

Introduction

The clinical differentiation of Parkinson’s disease (PD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) may be challenging, especially in their early stages. The aim of this study was to evaluate the utility of apparent diffusion coefficient (ADC) measurement to distinguish among these degenerative disorders.

Methods

Twenty-five MSA, 20 PSP, and 17 PD patients and 18 healthy controls were retrospectively studied. Axial diffusion-weighted and T2-weighted images were obtained using a 3-T MR system. Regions of interest (ROIs) were precisely placed in the midbrain, pons, putamen, globus pallidus, caudate nucleus, thalamus, superior cerebellar peduncle, middle cerebellar peduncle, cerebellar white matter, and cerebellar dentate nucleus, and the regional ADC (rADC) value was calculated in each ROI.

Results

In MSA, rADC values in the pons, middle cerebellar peduncle, cerebellar white matter, and cerebellar dentate nucleus were significantly higher than in PSP, PD, and controls. Furthermore, rADC values in the posterior putamen were significantly higher in MSA than in PSP and controls. In PSP, rADC values were significantly higher in the globus pallidus and midbrain than in MSA, PD, and controls. Furthermore, rADC values in the caudate nucleus and superior cerebellar peduncle were significantly higher in PSP than in MSA and controls. In PD, there were no significant differences in the rADC values compared to in MSA, PSP, and controls in all regions.

Conclusion

Evaluation of rADC values in characteristic lesions in MSA, PSP, and PD by placing ROIs using 3-T systems can provide useful additional information for differentiating these disorders.

Seppi K, Schocke MF, Wenning GK, Poewe W (2005) How to diagnose MSA early: the role of magnetic resonance imaging. J Neural Transm 112:1625–1634PubMedCrossRef

Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP (1997) Multiple system atrophy: a review of 203 pathologically proven cases. Mov Disord 12:133–147PubMedCrossRef

Wenning GK, Ben-Shlomo Y, Magalhães M, Daniel SE, Quinn NP (1995) Clinicopathological study of 35 cases of multiple system atrophy. J Neurol Neurosurg Psychiatry 58:160–166PubMedCrossRef

Ohshita T, Oka M, Imon Y, Yamaguchi S, Mimori Y, Nakamura S (2000) Apparent diffusion coefficient measurements in progressive supranuclear palsy. Neuroradiology 42:643–647PubMedCrossRef

Matsusue E, Fujii S, Kanasaki Y, Sugihara S, Miyata H, Ohama E, Ogawa T (2008) Putaminal lesion in multiple system atrophy: postmortem MR-pathological correlations. Neuroradiology 50:559–567PubMedCrossRef

Yekhlef F, Ballan G, Macia F, Delmer O, Sourgen C, Tison F (2003) Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD. J Neural Transm 110:151–169PubMedCrossRef

Kashihara K, Shinya T, Higaki F (2011) Reduction of neuromelanin-positive nigral volume in patients with MSA, PSP and CBD. Intern Med 50:1683–1687PubMedCrossRef

Lee EA, Cho HI, Kim SS, Lee WY (2004) Comparison of magnetic resonance imaging in subtypes of multiple system atrophy. Parkinsonism Relat Disord 10:363–368PubMedCrossRef

Warmuth-Metz M, Naumann M, Csoti I, Solymosi L (2001) Measurement of the midbrain diameter on routine magnetic resonance imaging: a simple and accurate method of differentiating between Parkinson disease and progressive supranuclear palsy. Arch Neurol 58:1076–1079PubMedCrossRef

10.

Bhattacharya K, Saadia D, Eisenkraft B, Yahr M, Olanow W, Drayer B, Kaufmann H (2002) Brain magnetic resonance imaging in multiple-system atrophy and Parkinson disease: a diagnostic algorithm. Arch Neurol 59:835–842PubMedCrossRef

11.

Quattrone A, Nicoletti G, Messina D, Fera F, Condino F, Pugliese P, Lanza P, Barone P, Morgante L, Zappia M, Aguglia U, Gallo O (2007) MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology 246:214–221PubMedCrossRef

12.

Paviour DC, Price SL, Jahanshahi M, Lees AJ, Fox NC (2006) Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations. Mov Disord 21:989–996PubMedCrossRef

13.

Oba H, Yagishita A, Terada H, Barkovich AJ, Kutomi K, Yamauchi T, Furui S, Shimizu T, Uchigata M, Matsumura K, Sonoo M, Sakai M, Takada K, Harasawa A, Takeshita K, Kohtake H, Tanaka H, Suzuki S (2005) New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology 64:2050–2055PubMedCrossRef

14.

Seppi K, Schocke MF, Mair KJ, Esterhammer R, Scherfler C, Geser F, Kremser C, Boesch S, Jaschke W, Poewe W, Wenning GK (2006) Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study. Neuroimage 31:240–245PubMedCrossRef

15.

Pellecchia MT, Barone P, Mollica C, Salvatore E, Ianniciello M, Longo K, Varrone A, Vicidomini C, Picillo M, De Michele G, Filla A, Salvatore M, Pappatà S (2009) Diffusion-weighted imaging in multiple system atrophy: a comparison between clinical subtypes. Mov Disord 24:689–696PubMedCrossRef

16.

Paviour DC, Thornton JS, Lees AJ, Jäger HR (2007) Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsy. Mov Disord 22:68–74PubMedCrossRef

17.

Seppi K, Schocke MF, Esterhammer R, Kremser C, Brenneis C, Mueller J, Boesch S, Jaschke W, Poewe W, Wenning GK (2003) Diffusion-weighted imaging discriminates progressive supranuclear palsy from PD, but not from the Parkinson variant of multiple system atrophy. Neurology 60:922–927PubMedCrossRef

18.

Erbetta A, Mandelli ML, Savoiardo M, Grisoli M, Bizzi A, Soliveri P, Chiapparini L, Prioni S, Bruzzone MG, Girotti F (2009) Diffusion tensor imaging shows different topographic involvement of the thalamus in progressive supranuclear palsy and corticobasal degeneration. AJNR Am J Neuroradiol 30:1482–1487PubMedCrossRef

19.

Schocke MF, Seppi K, Esterhammer R, Kremser C, Jaschke W, Poewe W, Wenning GK (2002) Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD. Neurology 58:575–580PubMedCrossRef

20.

Kanazawa M, Shimohata T, Terajima K, Onodera O, Tanaka K, Tsuji S, Okamoto K, Nishizawa M (2004) Quantitative evaluation of brainstem involvement in multiple system atrophy by diffusion-weighted MR imaging. J Neurol 251:1121–1124PubMedCrossRef

21.

Horimoto Y, Aiba I, Yasuda T, Ohkawa Y, Katayama T, Yokokawa Y, Goto A, Ito Y (2002) Longitudinal MRI study of multiple system atrophy—when do the findings appear, and what is the course? J Neurol 249:847–854PubMedCrossRef

22.

Frayne R, Goodyear BG, Dickhoff P, Lauzon ML, Sevick RJ (2003) Magnetic resonance imaging at 3.0 Tesla: challenges and advantages in clinical neurological imaging. Invest Radiol 38:385–402PubMed

23.

Arabia G, Morelli M, Paglionico S, Novellino F, Salsone M, Giofrè L, Torchia G, Nicoletti G, Messina D, Condino F, Lanza P, Gallo O, Quattrone A (2010) An magnetic resonance imaging T2*-weighted sequence at short echo time to detect putaminal hypointensity in Parkinsonisms. Mov Disord 25:2728–2734PubMedCrossRef

24.

Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele–Richardson–Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47:1–9PubMedCrossRef

25.

Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ, Kaufmann H, Klockgether T, Lang AE, Lantos PL, Litvan I, Mathias CJ, Oliver E, Robertson D, Schatz I, Wenning GK (1999) Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 163:94–98PubMedCrossRef

26.

Calne DB, Snow BJ, Lee C (1992) Criteria for diagnosing Parkinson's disease. Ann Neurol 32(Suppl):S125–S127PubMedCrossRef

27.

Wang PS, Wu HM, Lin CP, Soong BW (2011) Use of diffusion tensor imaging to identify similarities and differences between cerebellar and Parkinsonism forms of multiple system atrophy. Neuroradiology 53:471–481PubMedCrossRef

28.

Nicoletti G, Tonon C, Lodi R, Condino F, Manners D, Malucelli E, Morelli M, Novellino F, Paglionico S, Lanza P, Messina D, Barone P, Morgante L, Zappia M, Barbiroli B, Quattrone A (2008) Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease. Mov Disord 23:2370–2376PubMedCrossRef

29.

Rizzo G, Martinelli P, Manners D, Scaglione C, Tonon C, Cortelli P, Malucelli E, Capellari S, Testa C, Parchi P, Montagna P, Barbiroli B, Lodi R (2008) Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease. Brain 131:2690–2700PubMedCrossRef

30.

Messina D, Cerasa A, Condino F, Arabia G, Novellino F, Nicoletti G, Salsone M, Morelli M, Lanza PL, Quattrone A (2011) Patterns of brain atrophy in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy. Parkinsonism Relat Disord 17:172–176PubMedCrossRef

31.

Watanabe H, Ito M, Fukatsu H, Senda J, Atsuta N, Kaga T, Kato S, Katsuno M, Tanaka F, Hirayama M, Naganawa S, Sobue G (2010) Putaminal magnetic resonance imaging features at various magnetic field strengths in multiple system atrophy. Mov Disord 25:1916–1923PubMedCrossRef

Title: Significance of apparent diffusion coefficient measurement for the differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and Parkinson's disease: evaluation by 3.0-T MR imaging
Authors: Kazumichi Tsukamoto
Eiji Matsusue
Yoshiko Kanasaki
Suguru Kakite
Shinya Fujii
Toshio Kaminou
Toshihide Ogawa
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 9/2012
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-012-1009-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Significance of apparent diffusion coefficient measurement for the differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and Parkinson's disease: evaluation by 3.0-T MR imaging

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 9/2012

Long-term outcome in patients with carotid artery stenting and contralateral carotid occlusion: a single neurovascular center prospective analysis

Quantitative assessment of changes in carotid plaques during cilostazol administration using three-dimensional ultrasonography and non-gated magnetic resonance plaque imaging

A comparison of microstructural maturational changes of the corpus callosum in preterm and full-term children: a diffusion tensor imaging study

Comparison of 64-row and 16-row multidetector CT in the perfusion CT evaluation of acute ischemic stroke patients receiving intravenous thrombolytic therapy

Semi-automatic quantitative measurements of intracranial internal carotid artery stenosis and calcification using CT angiography

Dyke–Davidoff–Masson syndrome or fibrous dysplasia: response to a “Letter to the Editor”