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Published in: Neuroradiology 7/2012

01-07-2012 | Functional Neuroradiology

In vivo evaluation of white matter pathology in patients of progressive supranuclear palsy using TBSS

Authors: Jitender Saini, Bhavani Shankara Bagepally, Mangalore Sandhya, Shaik Afsar Pasha, Ravi Yadav, Pramod Kumar Pal

Published in: Neuroradiology | Issue 7/2012

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Abstract

Introduction

The purpose of this research is to study white matter (WM) changes in patients of progressive supranuclear palsy (PSP) using automated analysis of diffusion tensor imaging (DTI) indices.

Methods

This was a prospective study comprising of 24 patients of PSP and 26 matched healthy controls. Fractional anisotropy, mean diffusivity (MD), axial diffusivity, and radial diffusivity (RD) changes were studied in the WM of the PSP patients using an automated analysis technique, tract-based spatial statistics (TBSS). Two subtypes of PSP, i.e., classic Richardson’s syndrome (PSP-RS) and parkinsonian type (PSP-P), were also compared among themselves to identify relative severity of WM changes as well as identify spatial distribution of the differences. Clinicoradiological correlation was done to determine the strength of correlation between WM abnormalities identified using TBSS and clinical scores.

Results

There were areas of significant abnormality seen in the frontoparietal cerebral WM, thalamus, midbrain tectum, superior cerebellar peduncle, and cerebellar WM. The abnormalities were more spatially widespread on MD and RD maps. Compared to PSP-P, the patients of PSP-RS had more spatial abnormalities localized to the frontal WM. There was no correlation between the observed WM changes and clinical rating scales.

Conclusions

The TBSS analysis showed widespread WM abnormalities in PSP patients including areas which have been shown to be involved in previous pathological studies. PSP-RS showed more severe white matter abnormality compared to the PSP-P subtype.
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Metadata
Title
In vivo evaluation of white matter pathology in patients of progressive supranuclear palsy using TBSS
Authors
Jitender Saini
Bhavani Shankara Bagepally
Mangalore Sandhya
Shaik Afsar Pasha
Ravi Yadav
Pramod Kumar Pal
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 7/2012
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-011-0983-7

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