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Neuroradiology

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01-01-2009 | Diagnostic Neuroradiology

Normal regional fractional anisotropy and apparent diffusion coefficient of the brain measured on a 3 T MR scanner

Authors: Christabel E. C. Lee, Laura E. Danielian, David Thomasson, Eva H. Baker

Published in: Neuroradiology | Issue 1/2009

Abstract

Introduction

We aim to establish norms of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in 20 different regions of the brain in healthy human volunteers.

Methods

Thirty-one individuals were examined for ADC and FA in 20 regions of the brain using a single-shot, spin echo, echo planar diffusion tensor imaging sequence with 32 directions at 3 T. FA and ADC maps were computed using the Philips PRIDE tool, and regions of interest were drawn at 20 different locations in the brain. Relationships of FA and ADC with age and gender were explored.

Results

We found a negative correlation between age and FA in the inferior fronto-occipital fasciculus and forceps minor. There were no gender differences. The cerebral peduncle, the middle cerebellum, and cingulum had the highest variation in FA, while fornix, optic radiation, and optic tract had the highest variation in ADC.

Conclusion

We provide a table of normative FA and ADC measurements in 20 brain regions of potential clinical relevance to the diagnosis and monitoring of specific neurological diseases.

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Title: Normal regional fractional anisotropy and apparent diffusion coefficient of the brain measured on a 3 T MR scanner
Authors: Christabel E. C. Lee
Laura E. Danielian
David Thomasson
Eva H. Baker
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 1/2009
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-008-0441-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Normal regional fractional anisotropy and apparent diffusion coefficient of the brain measured on a 3 T MR scanner

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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