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01-07-2005 | Diagnostic Neuroradiology

Meningioma growth and interferon beta-1b treated multiple sclerosis: coincidence or relationship?

Authors: A. Drevelegas, E. Xinou, D. Karacostas, D. Parissis, G. Karkavelas, I. Milonas

Published in: Neuroradiology | Issue 7/2005

Abstract

Although the coincidence of multiple sclerosis (MS) and central nervous system (CNS) tumors has been reported in over 30 cases in English literature, meningioma growth was associated with interferon-beta (INF-b) treated MS only in two of them. We report the case of a 19-year-old woman with clinically possible, laboratory supported MS, and a concomitant right intraventricular tumor with magnetic resonance imaging (MRI) characteristics consistent with meningioma (similar signal with grey matter on T1 and T2-weighted images and homogenous, intense enhancement). Two years after initiation of INF-b treatment, follow-up brain MRI revealed enlargement of the intraventricular mass and relative increase in the number of white matter lesions without significant clinical deterioration. She underwent almost total resection of the mass and histology confirmed the diagnosis of papillary meningioma. Based on the immunohistochemistry results, we speculate that INF-b resulted in meningioma growth by enhancing platelet derived growth factor (PDGF) receptors or/and down-regulating transforming growth factor receptors on the tumor itself.

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Title: Meningioma growth and interferon beta-1b treated multiple sclerosis: coincidence or relationship?
Authors: A. Drevelegas
E. Xinou
D. Karacostas
D. Parissis
G. Karkavelas
I. Milonas
Publication date: 01-07-2005
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 7/2005
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-005-1392-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Meningioma growth and interferon beta-1b treated multiple sclerosis: coincidence or relationship?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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