Top

Published in:

01-12-2003 | Diagnostic Neuroradiology

Proton MRS in Behçet’s disease with and without neurological findings

Authors: T. Baysal, H. I. Ozisik, R. Karlidag, K. Sarac, O. Baysal, A. Dusak, E. Hazneci, C. Ozcan

Published in: Neuroradiology | Issue 12/2003

Abstract

Our aim was to investigate whether neurological impairment in Behçet’s disease (BD) can be assessed by means of proton MRS and whether it can assist in prognosis. We used single-voxel MRS to measure metabolites in regions of normal-appearing pons, basal ganglia and periventricular white matter (PWM) in 32 patients with chronic BD patients with and without neurological deficits and 29 control subjects. Patients had significantly higher N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios in the basal ganglia than the controls. The Cho/Cr ratio in the PWM was also significantly higher in the patients. MRS enabled clear discrimination of patients and controls and also revealed spectral differences between non-neuro-Behçet’s disease and neuro-Behçet’s disease in the basal ganglia. MRS can be used to assess brain involvement in BD even if structural changes are absent.

Behçet H (1937) Über residivierende, aphtöse, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Derm Wochenschr 105: 1152–1157

International Study Group for Behcet’s Disease (1990) Criteria for diagnosis of Behcet’s disease. Lancet 335: 1078–1080PubMed

Serdaroglu P, Yazici H, Ozdemir C, et al (1989) Neurologic involvement in Behcet’s syndrome. A prospective study. Arch Neurol 46: 265–269PubMed

Yazici H (1993) Behçet’ syndrome. In: Maddison RJ, Isenberg DA, Woo P, Glass DN (eds) Oxford textbook of rheumatology. Oxford Medical Publications, Oxford, pp 884–889

Gerber S, Biondi A, Dormont D, et al (1996) Long-term MR follow-up of cerebral lesions in neuro-Behcet’s disease. Neuroradiology 38: 761–768CrossRefPubMed

Banna M, el-Ramahl K (1991) Neurologic involvement in Behcet disease: imaging findings in 16 patients. AJNR 12: 791–796

Mizukami K, Shiraishi H, Tanaka Y, et al (1992) CNS changes in neuro-Behcet’s disease: CT, MR, and SPECT findings. Comput Med Imaging Graph 16: 401–406PubMed

Constantinidis I (2000) MRS methodology. Adv Neurol 83: 235–246PubMed

Lenkinski RE (2001) MR spectroscopy: clinical tool or research probe? Acad Radiol 8: 567–570PubMed

10.

Hund-Georgiadis M, Norris DG, Guthke T, von Cramon DY (2001) Characterization of cerebral small vessel disease by proton spectroscopy and morphological magnetic resonance. Cerebrovasc Dis 15: 82–90CrossRef

11.

Howe FA, Maxwell RJ, Saunders DE, et al (1993) Proton spectroscopy in vivo. Magn Reson Q 9: 31–59PubMed

12.

Tali ET, Atilla S, Keskin T, et al (1997) MRI in neuro-Behcet’s disease. Neuroradiology 39: 2–6CrossRefPubMed

13.

Patel DV, Neuman MJ, Hier DB (1989) Reversibility of CT and MR findings in neuro-Behcet disease. J Comput Assist Tomogr 13: 669–673PubMed

14.

Wechsler B, Dell’lsola B, Vidailhet M, et al (1993) MRI in 31 patients with Behcet’s disease and neurological involvement: prospective study with clinical correlation. J Neurol Neurosurg Psychiatry 56: 793–798PubMed

15.

Jennette JC, Falk RJ, Milling DM (1994) Pathogenesis of vasculitis. Semin Neurol 14: 291–299PubMed

16.

Hurst RW, Grossman RI (1994) Neuroradiology of central nervous system vasculitis. Semin Neurol 14: 320–340PubMed

17.

Kocer N, Islak C, Siva A, et al (1999) CNS involvement in neuro-Behcet syndrome: an MR study. AJNR 20: 1015–1024PubMed

18.

Siva A, Kantarci OH, Saip S, et al (2001) Behcet’s disease: diagnostic and prognostic aspects of neurological involvement. J Neurol 248: 95–103CrossRefPubMed

19.

Morrissey SP, Miller DH, Hermaszewski R, et al (1993) Magnetic resonance imaging of the central nervous system in Behcet’s disease. Eur Neurol 33: 287–293PubMed

20.

Vignola S, Nobili F, Picco P, et al (2001) Brain perfusion spect in juvenile neuro-Behcet’s disease. J Nucl Med 42: 1151–1157PubMed

21.

Coban O, Bahar S, Akman-Demir G, et al (1999) Masked assessment of MRI findings: is it possible to differentiate neuro-Behcet’s disease from other central nervous system diseases? Neuroradiology 41: 255–260CrossRefPubMed

22.

Huang WS, Chiu PY, Kao A, et al (2002) Decreased cerebral blood flow in neuro-Behcet’s syndrome patients with neuropsychiatric manifestations and normal magnetic resonance imaging--a preliminary report. J Neuroimaging 12: 355–359PubMed

23.

Avci O, Kutluay E, Argon M, et al (1998) Subclinical cerebral involvement in Behcet’s disease: a SPECT study. Eur J Neurol 5: 49–53CrossRefPubMed

24.

McMenemey WH, Lawrence BJ (1957) Encephalomyelopathy in Behçet’s disease: report of necropsy findings in two cases. Lancet ii: 353–358CrossRef

25.

Kawakita H, Nishimura M, Satoh Y, et al (1967) Neurological aspects of Behcet’s disease. A case report and clinico-pathological review of the literature in Japan. J Neurol Sci 5: 417–438PubMed

26.

Ishino H, Higashi H, Otsuki S (1971) “Neuro-Behçet’s syndrome”. Case report with pathological findings. Folia Psychiatr Neurol Jpn 25: 27–36PubMed

27.

Smith JK, Londono A, Castillo M, et al (2002). Proton magnetic resonance spectroscopy of brain-stem lesions. Neuroradiology 44: 825-829CrossRefPubMed

28.

Nussel F, Wegmuller H, Laseyras F, Herschkowitz N, Huber P (1991) Neuro-Behcet: acute and sequential aspects by MRI and MRS. Eur Neurol 31: 399–402PubMed

29.

Schubert F, Seifert F, Elster C, et al (2002) Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-beta therapy on absolute metabolite concentrations. MAGMA 14: 213–222CrossRefPubMed

Title: Proton MRS in Behçet’s disease with and without neurological findings
Authors: T. Baysal
H. I. Ozisik
R. Karlidag
K. Sarac
O. Baysal
A. Dusak
E. Hazneci
C. Ozcan
Publication date: 01-12-2003
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 12/2003
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-003-1052-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Proton MRS in Behçet’s disease with and without neurological findings

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 12/2003

Posterior encephalopathy with vasospasm: MRI and angiography

Primary intraventricular brain abscess

Disappearance of cerebral arteriovenous malformations after partial endovascular embolisation: four cases with follow-up

Venous variations in the region of the third ventricle: the role of MR venography

Is haemosiderin visible indefinitely on gradient-echo MRI following traumatic intracerebral haemorrhage?

The effect of magnetisation transfer contrast on cerebrospinal fluid on motion artefacts on fluid-attenuated inversion-recovery images