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Published in: Calcified Tissue International 2/2013

01-02-2013 | Review

Genetic Regulation of Vitamin D Levels

Authors: Zari Dastani, Rui Li, Brent Richards

Published in: Calcified Tissue International | Issue 2/2013

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Abstract

Vitamin D plays several roles in the body, influencing bone health as well as serum calcium and phosphate levels. Further, vitamin D may modify immune function, cell proliferation, differentiation, and apoptosis. Vitamin D deficiency has been associated with numerous health outcomes, including bone disease, cancer, autoimmune disease, infectious disease, type 1 and type 2 diabetes, hypertension, and heart disease, although it is unclear whether or not these associations are causal. Various twin and family studies have demonstrated moderate to high heritability for circulating vitamin D levels. Accordingly, many studies have investigated the genetic determinants of this hormone. Recent advances in the methodology of large-scale genetic association studies, including coordinated international collaboration, have identified associations of CG, DHCR1, CYP2R1, VDR, and CYP24A1 with serum levels of vitamin D. Here, we review the genetic determinants of vitamin D levels by focusing on new findings arising from candidate gene and genomewide association studies.
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Metadata
Title
Genetic Regulation of Vitamin D Levels
Authors
Zari Dastani
Rui Li
Brent Richards
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Calcified Tissue International / Issue 2/2013
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-012-9660-z

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