Published in:
01-05-2009
25-Hydroxyvitamin D is not Associated with Carotid Intima-Media Thickness in Older Men and Women
Authors:
Stefan Pilz, Ronald M. A. Henry, Marieke B. Snijder, Rob M. van Dam, Giel Nijpels, Coen D. A. Stehouwer, Andreas Tomaschitz, Thomas R. Pieber, Jacqueline M. Dekker
Published in:
Calcified Tissue International
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Issue 5/2009
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Excerpt
Recent prospective studies highlighted vitamin D deficiency as a significant risk factor for cardiovascular events, but the underlying mechanisms remain unclear [
1]. In their recent work among 650 Old Order Amish persons, Michos et al. have demonstrated that 25-hydroxyvitamin D (25[OH]D) levels are not associated with carotid intima-media thickness (cIMT) and coronary artery calcification [
2]. These important findings suggest that the increased cardiovascular risk observed in persons with a poor vitamin D status is unlikely to be mediated by subclinical vascular disease. Considering, however, that 25(OH)D levels were significantly and inversely correlated with cIMT in another study among 390 patients with type 2 diabetes [
3], there still exists a need to address further the issue of 25(OH)D levels and cIMT. …
