Top

Published in:

01-09-2015 | Research Article

Temporal profile of the effects of regional anesthesia on the cutaneous reflexes of foot muscles

Authors: Isabella A. Mota, João B. Fernandes, Marcio N. Cardoso, Xavier Sala-Blanch, Markus Kofler, Josep Valls-Solé

Published in: Experimental Brain Research | Issue 9/2015

Abstract

We analyzed the effects of an anesthetic sciatic nerve block on the cutaneomuscular reflex (cMR) and the cutaneous silent period (cSP) of foot muscles, in order to investigate further the type of fibers involved in their generation. In 14 neurologically normal patients with indication for surgical treatment of hallux valgus, we recorded from the extensor digitorum brevis muscle the reflex responses elicited by high-intensity electrical stimulation of the big toe at various time periods, ranging from 0 to 20 min, after ultrasound-guided sciatic nerve popliteal anesthetic block. The first effect was a delay in cSP onset latency, with no changes in end latency. The cMR remained unaltered up to when subjects were no longer able to maintain the contraction. The effects of local anesthetics on peripheral nerves allow for recognition of the different types of fibers contributing to the cMR and the cSP in muscles of the lower limb.

Brull R, Macfarlane AJ, Parrington SJ, Koshkin A, Chan VW (2011) Is circumferential injection advantageous for ultrasound-guided popliteal sciatic nerve block?: a proof-of-concept study. Reg Anesth Pain Med 36:266–270CrossRefPubMed

Caccia MR, McComas AJ, Upton ARM, Blogg T (1973) Cutaneous reflexes in small muscles of the hand. J Neurol Neurosurg Psych 36:960–977CrossRef

Chen R, Ashby P, Lang AE (1992) Stimulus-sensitive myoclonus in akinetic-rigid syndromes. Brain 115:1875–1888CrossRefPubMed

Deshpande N, Metter EJ, Ling S, Conwit R, Ferrucci L (2008) Physiological correlates of age-related decline in vibrotactile sensitivity. Neurobiol Aging 29:765–773PubMedCentralCrossRefPubMed

Evans AL, Harrison LM, Stephens JA (1989) Task-dependent changes in cutaneous reflexes recorded from various muscles controlling finger movement in man. J Physiol 418:1–12PubMedCentralCrossRefPubMed

Fagius J, Wallin BG (1980) Sympathetic reflex latencies and conduction velocities in normal man. Neurol Sci 47:433–448CrossRef

Ferrari L, Crestan V, Sabattini G, Vinco F, Fontana S, Gozzi A (2010) Brain penetration of local anaesthetics in the rat: implications for experimental neuroscience. J Neurosci Methods 186:143–149CrossRefPubMed

Floeter MK (2003) Cutaneous silent periods. Muscle Nerve 28:391–401CrossRefPubMed

Garnett R, Stephens JA (1980) The reflex responses of single motor units in human first dorsal interosseous muscle following cutaneous afferent stimulation. J Physiol 303:351–364PubMedCentralCrossRefPubMed

Gibbs J, Harrison LM, Stephens JA (1995) Cutaneomuscular reflexes recorded from the lower limb in man during different tasks. J Physiol 487:237–242PubMedCentralCrossRefPubMed

Gokin AP, Philip B, Strichartz GR (2001) Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve. Anesthesiology 95:1441–1454CrossRefPubMed

Granacher U, Gruber M, Gollhofer A (2010) Force production capacity and functional reflex activity in young and elderly men. Aging Clin Exp Res 22:374–382CrossRefPubMed

Han JK, Oh K, Kim BJ, Koh SB, Kim JY, Park KW et al (2007) Cutaneous silent period in patients with restless leg syndrome. Clin Neurophysiol 118:1705–1710CrossRefPubMed

Inghilleri M, Cruccu G, Argenta M, Polidori L, Manfredi M (1997a) Silent period in upper limb muscles after noxious cutaneous stimulation in man. Electroencephalogr Clin Neurophysiol 105:109–115CrossRefPubMed

Inghilleri M, Cruccu G, Argenta M, Polidori L, Manfredi M (1997b) Silent period in upper limb muscles after noxious cutaneous stimulation in man. Electroenceph clin Neurophysiol 105:109–115CrossRefPubMed

Jenner JR, Stephens JA (1982) Cutaneous reflex responses, and their central nervous pathways studied in man. J Physiol 333:405–419PubMedCentralCrossRefPubMed

Kallio J, Avela J, Moritani T, Kanervo M, Selänne H, Komi P, Linnamo V (2010) Effects of ageing on motor unit activation patterns and reflex sensitivity in dynamic movements. J Electromyogr Kinesiol 20:590–598CrossRefPubMed

Kofler M (2003) Functional organization of exteroceptive inhibition following nociceptive electrical fingertip stimulation in humans. Clin Neurophysiol 114:973–980CrossRefPubMed

Kofler M, Poustka K (2004) Interside comparison of cutaneous silent periods in thenar muscles of healthy male and female subjects. Clin Neurophysiol 115:2123–2127CrossRefPubMed

Kofler M, Müller J, Reggiani L, Valls-Solé J (2001a) Influence of gender on auditory startle responses. Brain Res 921:206–210CrossRefPubMed

Kofler M, Müller J, Reggiani L, Valls-Solé J (2001b) Influence of age on auditory startle responses in humans. Neurosci Lett 307:65–68CrossRefPubMed

Kofler M, Kumru H, Stetkarova I, Schindler C, Fuhr P (2007) Muscle force up to 50 % of maximum does not affect cutaneous silent periods in thenar muscles. Clin Neurophysiol 118:2025–2030CrossRefPubMed

Kofler M, Valls-Solé J, Vasko P, Boček V, Stetkárová I (2014) Influence of limb temperature on cutaneous silent periods. Clin Neurophysiol 125:1826–1833CrossRefPubMed

Kranz H, Adorjani C, Baumgartner G (1973) The effect of nociceptive cutaneous stimuli on human motoneurons. Brain 96:571–590CrossRefPubMed

Kumru H, Opisso E, Valls-Solé J, Kofler M (2009) The effect of a prepulse stimulus on the EMG rebound following the cutaneous silent period. J Physiol 587:587–595PubMedCentralCrossRefPubMed

Leis AA, Kofler M, Ross MA (1992) The silent period in pure sensory neuronopathy. Muscle Nerve 15:1345–1348CrossRefPubMed

Leis AA, Stokic DS, Fuhr P, Kofler M, Kronenberg MF, Wissel J et al (2000) Nociceptive fingertip stimulation inhibits synergistic motoneuron pools in the human upper limb. Neurology. 55:1305–1309CrossRefPubMed

Lopergolo D, Isak B, Gabriele M, Onesti E, Ceccanti M, Capua G, Fionda L, Biasiotta A, Di Stefano G, La Cesa S, Frasca V, Inghilleri M (2014) Cutaneous silent period recordings in demyelinating and axonal polyneuropathies. Clin Neurophysiol. doi:10.1016/j.clinph.2014.11.013 PubMed

Lourenço G, Iglesias C, Cavallari P, Pierrot-Deseilligny E, Marchand-Pauvert V (2006) Mediation of late excitation from human hand muscles via parallel group II spinal and group I transcortical pathways. J Physiol 572:585–603PubMedCentralCrossRefPubMed

McNulty PA, Macefield VG (2001) Modulation of ongoing EMG by different classes of low-threshold mechanoreceptors in the human hand. J Physiol 537:1021–1032PubMedCentralCrossRefPubMed

Meinck HM, Benecke R, Küster S, Conrad B (1983) Cutaneomuscular (flexor) reflex organization in normal man and in patients with motor disorders. Adv Neurol 39:787–796PubMed

Missair A, Weisman RS, Suarez MR, Yang R, Gebhard RE (2012) A 3-dimensional ultrasound study of local anesthetic spread during lateral popliteal nerve block: what is the ideal end point for needle tip position? Reg Anesth Pain Med 37:627–632CrossRefPubMed

Onal MR, Ulas UH, Oz O, Bek VS, Yucel M, Taslıpınar A et al (2010) Cutaneous silent period changes in type 2 diabetes mellitus patients with small fiber neuropathy. Clin Neurophysiol 121:714–718CrossRefPubMed

Rodi Z, Springer C (2011) Influence of muscle contraction and intensity of stimulation on the cutaneous silent period. Muscle Nerve 43:324–328CrossRefPubMed

Romaniello A, Truini A, Galeotti F, De Lena C, Willer JC, Cruccu G (2004) Cutaneous silent period in hand muscle is evoked by laser stimulation of the palm, but not the hand dorsum. Muscle Nerve 29:870–872CrossRefPubMed

Rossi P, Pierelli F, Parisi L, Perrotta A, Bartolo M, Amabile G et al (2003) Effect of painful heterotopic stimulation on the cutaneous silent period in the upper limbs. Clin Neurophysiol 114:1–6CrossRefPubMed

Sala-Blanch X, de Riva N, Carrera A, López AM, Prats A, Hadzic A (2012) Ultrasound-guided popliteal sciatic block with a single injection at the sciatic division results in faster block onset than the classical nerve stimulator technique. Anesth Analg 114:1121–1127CrossRefPubMed

Serrao M, Parisia L, Pierellib F, Rossi P (2001) Cutaneous afferents mediating the cutaneous silent period in the upper limbs: evidences for a role of low-threshold sensory fibres. Clin Neurophysiol 112:2007–2014CrossRefPubMed

Serrao M, Parisi L, Valente G, Martini A, Fattapposta F, Pierelli F et al (2002) L-Dopa decreases cutaneous nociceptive inhibition of motor activity in Parkinson’s disease. Acta Neurol Scand 105:196–201CrossRefPubMed

Stetkarova I, Kofler M (2013) Differential effect of baclofen on cortical and spinal inhibitory circuits. Clin Neurophysiol 124:339–345CrossRefPubMed

Svilpauskaite J, Truffert A, Vaiciene N, Magistris MR (2006) Electrophysiology of small peripheral nerve fibers in man. A study using the cutaneous silent period. Medicina (Kaunas) 42:300–313

Tataroglu C, Uludag B, Karapinar N, Bademkiran F, Ertekin C (2005) Cutaneous silent periods of the vastus medialis evoked by the stimulation of lateral femoral cutaneous nerve. Clin Neurophysiol 116:1335–1341CrossRefPubMed

Truini A, Padua L, Biasiotta A, Caliandro P, Pazzaglia C, Galeotti F et al (2009) Differential involvement of A-delta and A-beta fibres in neuropathic pain related to carpal tunnel syndrome. Pain 145:105–109CrossRefPubMed

Turner LC, Harrison LM, Stephens JA (2002) Finger movement is associated with attenuated cutaneous reflexes recorded from human first dorsal interosseous muscle. J Physiol 542:559–566PubMedCentralCrossRefPubMed

Verdú E, Ceballos D, Vilches JJ, Navarro X (2000) Influence of aging on peripheral nerve function and regeneration. J Peripher Nerv Syst 5:191–208CrossRefPubMed

Yoon TS, Han SJ, Lee JE, Park DS, Jun AY (2011) Changes in the cutaneous silent period by paired stimulation. Neurophysiol Clin 41:67–72CrossRefPubMed

Title: Temporal profile of the effects of regional anesthesia on the cutaneous reflexes of foot muscles
Authors: Isabella A. Mota
João B. Fernandes
Marcio N. Cardoso
Xavier Sala-Blanch
Markus Kofler
Josep Valls-Solé
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Experimental Brain Research / Issue 9/2015
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-015-4329-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Temporal profile of the effects of regional anesthesia on the cutaneous reflexes of foot muscles

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 9/2015

Gain of postural responses increases in response to real and anticipated pain

Hazard levels of warning signal words modulate the inhibition of return effect: evidence from the event-related potential P300

Similar frequency of the McGurk effect in large samples of native Mandarin Chinese and American English speakers

Hitting moving targets with a continuously changing temporal window

Does metabosensitive afferent fibers activity differ from slow- and fast-twitch muscles?

Polymorphism in the µ-opioid receptor gene (OPRM1) modulates neural processing of physical pain, social rejection and error processing