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Open Access 01-07-2010 | Research Article

Simply longer is not better: reversal of theta burst after-effect with prolonged stimulation

Authors: Olga Lucía Gamboa, Andrea Antal, Vera Moliadze, Walter Paulus

Published in: Experimental Brain Research | Issue 2/2010

Abstract

From all rTMS protocols at present, the theta burst stimulation (TBS) is considered the most efficient in terms of number of impulses and intensity required during a given stimulation. The aim of this study was to investigate the effects of inhibitory and excitatory TBS protocols on motor cortex excitability when the duration of stimulation was doubled. Fourteen healthy volunteers were tested under four conditions: intermittent theta bust stimulation (iTBS), continuous theta burst stimulation (cTBS), prolonged intermittent theta bust stimulation (ProiTBS) and prolonged continuous theta burst stimulation (ProcTBS). The prolonged paradigms were twice as long as the conventional TBS protocols. Conventional facilitatory iTBS converted into inhibitory when it was applied for twice as long, while the normally inhibitory cTBS became facilitatory when the stimulation duration was doubled. Our results show that TBS-induced plasticity cannot be deliberately enhanced simply by prolonging TBS protocols. Instead, when stimulating too long, after-effects will be reversed. This finding supplements findings at the short end of the stimulation duration range, where it was shown that conventional cTBS is excitatory in the first half and switches to inhibition only after the full length protocol. It is relevant for clinical applications for which an ongoing need for further protocol improvement is imminent.

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Title: Simply longer is not better: reversal of theta burst after-effect with prolonged stimulation
Authors: Olga Lucía Gamboa
Andrea Antal
Vera Moliadze
Walter Paulus
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: Experimental Brain Research / Issue 2/2010
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-010-2293-4

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Simply longer is not better: reversal of theta burst after-effect with prolonged stimulation

Abstract

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