Skip to main content
Top
Published in: Experimental Brain Research 4/2010

01-05-2010 | Research Article

Robot-assisted modifications of gait in healthy individuals

Authors: Seok Hun Kim, Sai K. Banala, Elizabeth A. Brackbill, Sunil K. Agrawal, Vijaya Krishnamoorthy, John P. Scholz

Published in: Experimental Brain Research | Issue 4/2010

Login to get access

Abstract

This study investigated whether short-term modifications of gait could be induced in healthy adults and whether a combination of kinetic (a compliant force resisting deviation of the foot from the prescribed footpath) and visual guidance was superior to either kinetic guidance or visual guidance alone in producing this modification. Thirty-nine healthy adults, 20–33 years old, were randomly assigned to the three groups receiving six 10-min blocks of treadmill training requiring them to modify their footpath to match a scaled-down path. Changes of the footpath, specific joint events and joint moments were analyzed. Persons receiving combined kinetic and visual guidance showed larger modifications of their gait patterns that were maintained longer, persisting up to 2 h after intervening over-ground activities, than did persons receiving training with primarily kinetic guidance or with visual guidance alone. The results emphasize the short-term plasticity of locomotor circuits and provide a possible basis for persons learning to achieve more functional gait patterns following a stroke or other neurological disorders.
Literature
go back to reference Arnold AS, Schwartz MH, Thelen DG, Delp SL (2007) Contributions of muscles to terminal-swing knee motions vary with walking speed. J Biomech 40:3660–3671CrossRefPubMed Arnold AS, Schwartz MH, Thelen DG, Delp SL (2007) Contributions of muscles to terminal-swing knee motions vary with walking speed. J Biomech 40:3660–3671CrossRefPubMed
go back to reference Banala S, Agrawal SK, Fattah A, Krishnamoorthy V, Hsu WL, Scholz JP, Rudolph K (2006) Gravity-balancing leg orthosis and its performance evaluation. IEEE Trans Robotics 22:1228–1237CrossRef Banala S, Agrawal SK, Fattah A, Krishnamoorthy V, Hsu WL, Scholz JP, Rudolph K (2006) Gravity-balancing leg orthosis and its performance evaluation. IEEE Trans Robotics 22:1228–1237CrossRef
go back to reference Banala S, Kulpe A, Agrawal SK (2007) A powered leg orthosis for gait rehabilitation of motor-impaired patients. In: IEEE international conference on robotics and automation, Rome, Italy, pp 4140–4145 Banala S, Kulpe A, Agrawal SK (2007) A powered leg orthosis for gait rehabilitation of motor-impaired patients. In: IEEE international conference on robotics and automation, Rome, Italy, pp 4140–4145
go back to reference Banala SK, Kim SH, Agrawal SK, Scholz JP (2009) Robot assisted gait training with active leg exoskeleton (ALEX). IEEE Trans Neural Syst Rehabil Eng 17:2–8CrossRefPubMed Banala SK, Kim SH, Agrawal SK, Scholz JP (2009) Robot assisted gait training with active leg exoskeleton (ALEX). IEEE Trans Neural Syst Rehabil Eng 17:2–8CrossRefPubMed
go back to reference Bhushan N, Shadmehr R (1999) Computational nature of human adaptive control during learning of reaching movements in force fields. Biol Cybern 81:39–60CrossRefPubMed Bhushan N, Shadmehr R (1999) Computational nature of human adaptive control during learning of reaching movements in force fields. Biol Cybern 81:39–60CrossRefPubMed
go back to reference Bosco G, Poppele RE (1997) Representation of multiple kinematic parameters of the cat hindlimb in spinocerebellar activity. J Neurophysiol 78:1421–1432PubMed Bosco G, Poppele RE (1997) Representation of multiple kinematic parameters of the cat hindlimb in spinocerebellar activity. J Neurophysiol 78:1421–1432PubMed
go back to reference Bosco G, Poppele RE (2003) Modulation of dorsal spinocerebellar responses to limb movement. II. Effect of sensory input. J Neurophysiol 90:3372–3383CrossRefPubMed Bosco G, Poppele RE (2003) Modulation of dorsal spinocerebellar responses to limb movement. II. Effect of sensory input. J Neurophysiol 90:3372–3383CrossRefPubMed
go back to reference Bosco G, Rankin A, Poppele R (1996) Representation of passive hindlimb postures in cat spinocerebellar activity. J Neurophysiol 76:715–726PubMed Bosco G, Rankin A, Poppele R (1996) Representation of passive hindlimb postures in cat spinocerebellar activity. J Neurophysiol 76:715–726PubMed
go back to reference Bosco G, Poppele RE, Eian J (2000) Reference frames for spinal proprioception: limb endpoint based or joint-level based? J Neurophysiol 83:2931–2945PubMed Bosco G, Poppele RE, Eian J (2000) Reference frames for spinal proprioception: limb endpoint based or joint-level based? J Neurophysiol 83:2931–2945PubMed
go back to reference Brashers-Krug T, Shadmehr R, Bizzi E (1996) Consolidation in human motor memory. Nature 382:252–255CrossRefPubMed Brashers-Krug T, Shadmehr R, Bizzi E (1996) Consolidation in human motor memory. Nature 382:252–255CrossRefPubMed
go back to reference Buch ER, Young S, Contreras-Vidal JL (2003) Visuomotor adaptation in normal aging. Learn Mem 10:55–63CrossRefPubMed Buch ER, Young S, Contreras-Vidal JL (2003) Visuomotor adaptation in normal aging. Learn Mem 10:55–63CrossRefPubMed
go back to reference Cai LL, Fong AJ, Otoshi CK, Liang Y, Burdick JW, Roy RR, Edgerton VR (2006) Implications of assist-as-needed robotic step training after a complete spinal cord injury on intrinsic strategies of motor learning. J Neurosci 26:10564–10568CrossRefPubMed Cai LL, Fong AJ, Otoshi CK, Liang Y, Burdick JW, Roy RR, Edgerton VR (2006) Implications of assist-as-needed robotic step training after a complete spinal cord injury on intrinsic strategies of motor learning. J Neurosci 26:10564–10568CrossRefPubMed
go back to reference Choi JT, Bastian AJ (2007) Adaptation reveals independent control networks for human walking. Nat Neurosci 10:1055–1062CrossRefPubMed Choi JT, Bastian AJ (2007) Adaptation reveals independent control networks for human walking. Nat Neurosci 10:1055–1062CrossRefPubMed
go back to reference Colborne GR, Olney SJ, Griffin MP (1993) Feedback of ankle joint angle and soleus electromyography in the rehabilitation of hemiplegic gait. Arch Phys Med Rehabil 74:1100–1106CrossRefPubMed Colborne GR, Olney SJ, Griffin MP (1993) Feedback of ankle joint angle and soleus electromyography in the rehabilitation of hemiplegic gait. Arch Phys Med Rehabil 74:1100–1106CrossRefPubMed
go back to reference Colombo G, Joerg M, Schreier R, Dietz V (2000) Treadmill training of paraplegic patients using a robotic orthosis. J Rehabil Res Dev 37:693–700PubMed Colombo G, Joerg M, Schreier R, Dietz V (2000) Treadmill training of paraplegic patients using a robotic orthosis. J Rehabil Res Dev 37:693–700PubMed
go back to reference Daly JJ, Hogan N, Perepezko EM, Krebs HI, Rogers JM, Goyal KS, Dohring ME, Fredrickson E, Nethery J, Ruff RL (2005) Response to upper-limb robotics and functional neuromuscular stimulation following stroke. J Rehabil Res Dev 42:723–736CrossRefPubMed Daly JJ, Hogan N, Perepezko EM, Krebs HI, Rogers JM, Goyal KS, Dohring ME, Fredrickson E, Nethery J, Ruff RL (2005) Response to upper-limb robotics and functional neuromuscular stimulation following stroke. J Rehabil Res Dev 42:723–736CrossRefPubMed
go back to reference Dimitrijevic MR, Gerasimenko Y, Pinter MM (1998) Evidence for a spinal central pattern generator in humans. Ann N Y Acad Sci 860:360–376CrossRefPubMed Dimitrijevic MR, Gerasimenko Y, Pinter MM (1998) Evidence for a spinal central pattern generator in humans. Ann N Y Acad Sci 860:360–376CrossRefPubMed
go back to reference Dipietro L, Krebs HI, Fasoli SE, Volpe BT, Stein J, Bever C, Hogan N (2007) Changing motor synergies in chronic stroke. J Neurophysiol 98:757–768CrossRefPubMed Dipietro L, Krebs HI, Fasoli SE, Volpe BT, Stein J, Bever C, Hogan N (2007) Changing motor synergies in chronic stroke. J Neurophysiol 98:757–768CrossRefPubMed
go back to reference Donchin O, Shadmehr R (2004) Change of desired trajectory caused by training in a novel motor task. Conf Proc IEEE Eng Med Biol Soc 6:4495–4498PubMed Donchin O, Shadmehr R (2004) Change of desired trajectory caused by training in a novel motor task. Conf Proc IEEE Eng Med Biol Soc 6:4495–4498PubMed
go back to reference Fasoli SE, Krebs HI, Stein J, Frontera WR, Hogan N (2003) Effects of robotic therapy on motor impairment and recovery in chronic stroke. Arch Phys Med Rehabil 84:477–482CrossRefPubMed Fasoli SE, Krebs HI, Stein J, Frontera WR, Hogan N (2003) Effects of robotic therapy on motor impairment and recovery in chronic stroke. Arch Phys Med Rehabil 84:477–482CrossRefPubMed
go back to reference Fedirchuk B, Nielsen J, Petersen N, Hultborn H (1998) Pharmacologically evoked fictive motor patterns in the acutely spinalized marmoset monkey (Callithrix jacchus). Exp Brain Res 122:351–361CrossRefPubMed Fedirchuk B, Nielsen J, Petersen N, Hultborn H (1998) Pharmacologically evoked fictive motor patterns in the acutely spinalized marmoset monkey (Callithrix jacchus). Exp Brain Res 122:351–361CrossRefPubMed
go back to reference Franklin DW, So U, Burdet E, Kawato M (2007) Visual feedback is not necessary for the learning of novel dynamics. PLoS One 2:e1336CrossRefPubMed Franklin DW, So U, Burdet E, Kawato M (2007) Visual feedback is not necessary for the learning of novel dynamics. PLoS One 2:e1336CrossRefPubMed
go back to reference Goldberg EJ, Requejo PS, Fowler E.G (2009) Joint moment contributions to swing phase knee extension acceleration during gait in children with spastic hemiplegic cerebral palsy. J Biomech (in press) Goldberg EJ, Requejo PS, Fowler E.G (2009) Joint moment contributions to swing phase knee extension acceleration during gait in children with spastic hemiplegic cerebral palsy. J Biomech (in press)
go back to reference Grasso R, Ivanenko YP, Zago M, Molinari M, Scivoletto G, Lacquaniti F (2004) Recovery of forward stepping in spinal cord injured patients does not transfer to untrained backward stepping. Exp Brain Res 157:377–382CrossRefPubMed Grasso R, Ivanenko YP, Zago M, Molinari M, Scivoletto G, Lacquaniti F (2004) Recovery of forward stepping in spinal cord injured patients does not transfer to untrained backward stepping. Exp Brain Res 157:377–382CrossRefPubMed
go back to reference Hesse S, Uhlenbrock D (2000) A mechanized gait trainer for restoration of gait. J Rehabil Res Dev 37:701–708PubMed Hesse S, Uhlenbrock D (2000) A mechanized gait trainer for restoration of gait. J Rehabil Res Dev 37:701–708PubMed
go back to reference Hornby TG, Campbell DD, Kahn JH, Demott T, Moore JL, Roth HR (2008) Enhanced gait-related improvements after therapist- versus robotic-assisted locomotor training in subjects with chronic stroke: a randomized controlled study. Stroke 39:1786–1792CrossRefPubMed Hornby TG, Campbell DD, Kahn JH, Demott T, Moore JL, Roth HR (2008) Enhanced gait-related improvements after therapist- versus robotic-assisted locomotor training in subjects with chronic stroke: a randomized controlled study. Stroke 39:1786–1792CrossRefPubMed
go back to reference Husemann B, Muller F, Krewer C, Heller S, Koenig E (2007) Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study. Stroke 38:349–354CrossRefPubMed Husemann B, Muller F, Krewer C, Heller S, Koenig E (2007) Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study. Stroke 38:349–354CrossRefPubMed
go back to reference Hwang EJ, Smith MA, Shadmehr R (2006) Adaptation and generalization in acceleration-dependent force fields. Exp Brain Res 169:496–506CrossRefPubMed Hwang EJ, Smith MA, Shadmehr R (2006) Adaptation and generalization in acceleration-dependent force fields. Exp Brain Res 169:496–506CrossRefPubMed
go back to reference Ivanenko YP, Poppele RE, Lacquaniti F (2009) Distributed neural networks for controlling human locomotion: lessons from normal and SCI subjects. Brain Res Bull 78:13–21CrossRefPubMed Ivanenko YP, Poppele RE, Lacquaniti F (2009) Distributed neural networks for controlling human locomotion: lessons from normal and SCI subjects. Brain Res Bull 78:13–21CrossRefPubMed
go back to reference Kagerer FA, Contreras-Vidal JL, Stelmach GE (1997) Adaptation to gradual as compared with sudden visuo-motor distortions. Exp Brain Res 115:557–561CrossRefPubMed Kagerer FA, Contreras-Vidal JL, Stelmach GE (1997) Adaptation to gradual as compared with sudden visuo-motor distortions. Exp Brain Res 115:557–561CrossRefPubMed
go back to reference Krakauer JW, Ghez C, Ghilardi MF (2005) Adaptation to visuomotor transformations: consolidation, interference, and forgetting. J Neurosci 25:473–478CrossRefPubMed Krakauer JW, Ghez C, Ghilardi MF (2005) Adaptation to visuomotor transformations: consolidation, interference, and forgetting. J Neurosci 25:473–478CrossRefPubMed
go back to reference Krebs HI, Hogan N, Aisen ML, Volpe BT (1998) Robot-aided neurorehabilitation. IEEE Trans Rehabil Eng 6:75–87CrossRefPubMed Krebs HI, Hogan N, Aisen ML, Volpe BT (1998) Robot-aided neurorehabilitation. IEEE Trans Rehabil Eng 6:75–87CrossRefPubMed
go back to reference Latash ML, Scholz JP, Schöner G (2007) Toward a new theory of motor synergies. Mot Control 11:275–307 Latash ML, Scholz JP, Schöner G (2007) Toward a new theory of motor synergies. Mot Control 11:275–307
go back to reference Mayr A, Kofler M, Quirbach E, Matzak H, Frohlich K, Saltuari L (2007) Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the Lokomat gait orthosis. Neurorehabil Neural Repair 21:307–314CrossRefPubMed Mayr A, Kofler M, Quirbach E, Matzak H, Frohlich K, Saltuari L (2007) Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the Lokomat gait orthosis. Neurorehabil Neural Repair 21:307–314CrossRefPubMed
go back to reference Morris ME, Matyas TA, Bach TM, Goldie PA (1992) Electrogoniometric feedback: its effect on genu recurvatum in stroke. Arch Phys Med Rehabil 73:1147–1154PubMed Morris ME, Matyas TA, Bach TM, Goldie PA (1992) Electrogoniometric feedback: its effect on genu recurvatum in stroke. Arch Phys Med Rehabil 73:1147–1154PubMed
go back to reference Morton SM, Bastian AJ (2003) Relative contributions of balance and voluntary leg-coordination deficits to cerebellar gait ataxia. J Neurophysiol 89:1844–1856CrossRefPubMed Morton SM, Bastian AJ (2003) Relative contributions of balance and voluntary leg-coordination deficits to cerebellar gait ataxia. J Neurophysiol 89:1844–1856CrossRefPubMed
go back to reference Morton SM, Bastian AJ (2006) Cerebellar contributions to locomotor adaptations during splitbelt treadmill walking. J Neurosci 26:9107–9116CrossRefPubMed Morton SM, Bastian AJ (2006) Cerebellar contributions to locomotor adaptations during splitbelt treadmill walking. J Neurosci 26:9107–9116CrossRefPubMed
go back to reference O’Rourke J (1994) Computational Geometry in C. Cambridge University Press, New York O’Rourke J (1994) Computational Geometry in C. Cambridge University Press, New York
go back to reference Patton JL, Stoykov ME, Kovic M, Mussa-Ivaldi FA (2006) Evaluation of robotic training forces that either enhance or reduce error in chronic hemiparetic stroke survivors. Exp Brain Res 168:368–383CrossRefPubMed Patton JL, Stoykov ME, Kovic M, Mussa-Ivaldi FA (2006) Evaluation of robotic training forces that either enhance or reduce error in chronic hemiparetic stroke survivors. Exp Brain Res 168:368–383CrossRefPubMed
go back to reference Perry J (1992) Gait analysis: normal and pathological function. Slack Incorporated, Thorofare Perry J (1992) Gait analysis: normal and pathological function. Slack Incorporated, Thorofare
go back to reference Perry J, Garrett M, Gronley JK, Mulroy SJ (1995) Classification of walking handicap in the stroke population. Stroke 26:982–989PubMed Perry J, Garrett M, Gronley JK, Mulroy SJ (1995) Classification of walking handicap in the stroke population. Stroke 26:982–989PubMed
go back to reference Pohl M, Werner C, Holzgraefe M, Kroczek G, Mehrholz J, Wingendorf I, Hoolig G, Koch R, Hesse S (2007) Repetitive locomotor training and physiotherapy improve walking and basic activities of daily living after stroke: a single-blind, randomized multicentre trial (DEutsche GAngtrainerStudie, DEGAS). Clin Rehabil 21:17–27CrossRefPubMed Pohl M, Werner C, Holzgraefe M, Kroczek G, Mehrholz J, Wingendorf I, Hoolig G, Koch R, Hesse S (2007) Repetitive locomotor training and physiotherapy improve walking and basic activities of daily living after stroke: a single-blind, randomized multicentre trial (DEutsche GAngtrainerStudie, DEGAS). Clin Rehabil 21:17–27CrossRefPubMed
go back to reference Reinkensmeyer DJ, Kahn LE, Averbuch M, McKenna-Cole A, Schmit BD, Rymer WZ (2000) Understanding and treating arm movement impairment after chronic brain injury: progress with the ARM guide. J Rehabil Res Dev 37:653–662PubMed Reinkensmeyer DJ, Kahn LE, Averbuch M, McKenna-Cole A, Schmit BD, Rymer WZ (2000) Understanding and treating arm movement impairment after chronic brain injury: progress with the ARM guide. J Rehabil Res Dev 37:653–662PubMed
go back to reference Reisman DS, Block HJ, Bastian AJ (2005) Interlimb coordination during locomotion: what can be adapted and stored? J Neurophysiol 94:2403–2415CrossRefPubMed Reisman DS, Block HJ, Bastian AJ (2005) Interlimb coordination during locomotion: what can be adapted and stored? J Neurophysiol 94:2403–2415CrossRefPubMed
go back to reference Reisman DS, Wityk R, Silver K, Bastian AJ (2007) Locomotor adaptation on a split-belt treadmill can improve walking symmetry post-stroke. Brain 130:1861–1872CrossRefPubMed Reisman DS, Wityk R, Silver K, Bastian AJ (2007) Locomotor adaptation on a split-belt treadmill can improve walking symmetry post-stroke. Brain 130:1861–1872CrossRefPubMed
go back to reference Reisman DS, Wityk R, Silver K, Bastian AJ (2009) Split-belt treadmill adaptation transfers to overground walking in persons poststroke. Neurorehabil Neural Repair 23:735–744CrossRefPubMed Reisman DS, Wityk R, Silver K, Bastian AJ (2009) Split-belt treadmill adaptation transfers to overground walking in persons poststroke. Neurorehabil Neural Repair 23:735–744CrossRefPubMed
go back to reference Scheidt RA, Conditt MA, Secco EL, Mussa-Ivaldi FA (2005) Interaction of visual and proprioceptive feedback during adaptation of human reaching movements. J Neurophysiol 93:3200–3213CrossRefPubMed Scheidt RA, Conditt MA, Secco EL, Mussa-Ivaldi FA (2005) Interaction of visual and proprioceptive feedback during adaptation of human reaching movements. J Neurophysiol 93:3200–3213CrossRefPubMed
go back to reference Schmidt RA (1988) Motor control and learning: a behavioral emphasis. Human Kinetics Publishers Inc, Champaign Schmidt RA (1988) Motor control and learning: a behavioral emphasis. Human Kinetics Publishers Inc, Champaign
go back to reference Scholz JP, Schoner G, Latash ML (2000) Identifying the control structure of multijoint coordination during pistol shooting. Exp Brain Res 135:382–404CrossRefPubMed Scholz JP, Schoner G, Latash ML (2000) Identifying the control structure of multijoint coordination during pistol shooting. Exp Brain Res 135:382–404CrossRefPubMed
go back to reference Shadmehr R, Holcomb HH (1997) Neural correlates of motor memory consolidation. Science 277:821–825CrossRefPubMed Shadmehr R, Holcomb HH (1997) Neural correlates of motor memory consolidation. Science 277:821–825CrossRefPubMed
go back to reference Shadmehr R, Krakauer JW (2008) A computational neuroanatomy for motor control. Exp Brain Res 185:359–381CrossRefPubMed Shadmehr R, Krakauer JW (2008) A computational neuroanatomy for motor control. Exp Brain Res 185:359–381CrossRefPubMed
go back to reference Shadmehr R, Moussavi ZM (2000) Spatial generalization from learning dynamics of reaching movements. J Neurosci 20:7807–7815PubMed Shadmehr R, Moussavi ZM (2000) Spatial generalization from learning dynamics of reaching movements. J Neurosci 20:7807–7815PubMed
go back to reference Shadmehr R, Mussa-Ivaldi FA (1994) Adaptive representation of dynamics during learning of a motor task. J Neurosci 14:3208–3224PubMed Shadmehr R, Mussa-Ivaldi FA (1994) Adaptive representation of dynamics during learning of a motor task. J Neurosci 14:3208–3224PubMed
go back to reference Stein J, Krebs HI, Frontera WR, Fasoli SE, Hughes R, Hogan N (2004) Comparison of two techniques of robot-aided upper limb exercise training after stroke. Am J Phys Med Rehabil 83:720–728CrossRefPubMed Stein J, Krebs HI, Frontera WR, Fasoli SE, Hughes R, Hogan N (2004) Comparison of two techniques of robot-aided upper limb exercise training after stroke. Am J Phys Med Rehabil 83:720–728CrossRefPubMed
go back to reference Teasell RW, Bhogal SK, Foley NC, Speechley MR (2003) Gait retraining post stroke. Topic Stroke Rehabil 10:34–65 Teasell RW, Bhogal SK, Foley NC, Speechley MR (2003) Gait retraining post stroke. Topic Stroke Rehabil 10:34–65
go back to reference Tong C, Wolpert DM, Flanagan JR (2002) Kinematics and dynamics are not represented independently in motor working memory: evidence from an interference study. J Neurosci 22:1108–1113PubMed Tong C, Wolpert DM, Flanagan JR (2002) Kinematics and dynamics are not represented independently in motor working memory: evidence from an interference study. J Neurosci 22:1108–1113PubMed
go back to reference Tong RK, Ng MF, Li LS (2006) Effectiveness of gait training using an electromechanical gait trainer, with and without functional electric stimulation, in subacute stroke: a randomized controlled trial. Arch Phys Med Rehabil 87:1298–1304CrossRefPubMed Tong RK, Ng MF, Li LS (2006) Effectiveness of gait training using an electromechanical gait trainer, with and without functional electric stimulation, in subacute stroke: a randomized controlled trial. Arch Phys Med Rehabil 87:1298–1304CrossRefPubMed
go back to reference Winstein CJ (1991) Knowledge of results and motor learning–implications for physical therapy. Phys Ther 71:140–149PubMed Winstein CJ (1991) Knowledge of results and motor learning–implications for physical therapy. Phys Ther 71:140–149PubMed
go back to reference Yanagihara D, Kondo I (1996) Nitric oxide plays a key role in adaptive control of locomotion in cat. Proc Natl Acad Sci USA 93:13292–13297CrossRefPubMed Yanagihara D, Kondo I (1996) Nitric oxide plays a key role in adaptive control of locomotion in cat. Proc Natl Acad Sci USA 93:13292–13297CrossRefPubMed
Metadata
Title
Robot-assisted modifications of gait in healthy individuals
Authors
Seok Hun Kim
Sai K. Banala
Elizabeth A. Brackbill
Sunil K. Agrawal
Vijaya Krishnamoorthy
John P. Scholz
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
Experimental Brain Research / Issue 4/2010
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI
https://doi.org/10.1007/s00221-010-2187-5

Other articles of this Issue 4/2010

Experimental Brain Research 4/2010 Go to the issue