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01-04-2008 | Research Article

Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study

Authors: Tim Wagner, Uri Eden, Felipe Fregni, Antoni Valero-Cabre, Ciro Ramos-Estebanez, Valerie Pronio-Stelluto, Alan Grodzinsky, Markus Zahn, Alvaro Pascual-Leone

Published in: Experimental Brain Research | Issue 4/2008

Abstract

This paper is aimed at exploring the effect of cortical brain atrophy on the currents induced by transcranial magnetic stimulation (TMS). We compared the currents induced by various TMS conditions on several different MRI derived finite element head models of brain atrophy, incorporating both decreasing cortical volume and widened sulci. The current densities induced in the cortex were dependent upon the degree and type of cortical atrophy and were altered in magnitude, location, and orientation when compared to healthy head models. Predictive models of the degree of current density attenuation as a function of the scalp-to-cortex distance were analyzed, concluding that those which ignore the electromagnetic field–tissue interactions lead to inaccurate conclusions. Ultimately, the precise site and population of neural elements stimulated by TMS in an atrophic brain cannot be predicted based on healthy head models which ignore the effects of the altered cortex on the stimulating currents. Clinical applications of TMS should be carefully considered in light of these findings.

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Title: Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study
Authors: Tim Wagner
Uri Eden
Felipe Fregni
Antoni Valero-Cabre
Ciro Ramos-Estebanez
Valerie Pronio-Stelluto
Alan Grodzinsky
Markus Zahn
Alvaro Pascual-Leone
Publication date: 01-04-2008
Publisher: Springer-Verlag
Published in: Experimental Brain Research / Issue 4/2008
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-007-1258-8

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Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study

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