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Experimental Brain Research
Published in: Experimental Brain Research 1/2005

01-05-2005 | Research Note

Cholinergic cortical circuits in Parkinson’s disease and in progressive supranuclear palsy: a transcranial magnetic stimulation study

Authors: Raffaele Nardone, Igor Florio, Piergiorgio Lochner, Frediano Tezzon

Published in: Experimental Brain Research | Issue 1/2005

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Abstract

To investigate the involvement of the cortical cholinergic system in patients with Parkinson’s disease (PD) and with progressive supranuclear palsy (PSP), we performed a comparative study of the short latency afferent inhibition (SAI) in ten patients with PD, in eight patients with PSP and in 15 healthy subjects. Six of the PD patients and four of the PSP patients had dementia. SAI was significantly increased in the PD patients, whereas it was not significantly different between PSP patients and the normal controls. Our findings demonstrate that the excitability of the motor cortex is differentially modulated by sensory afferents in PD and PSP and may indicate that the mechanisms of cholinergic dysfunction are different between the two diseases.
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Metadata
Title
Cholinergic cortical circuits in Parkinson’s disease and in progressive supranuclear palsy: a transcranial magnetic stimulation study
Authors
Raffaele Nardone
Igor Florio
Piergiorgio Lochner
Frediano Tezzon
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Experimental Brain Research / Issue 1/2005
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI
https://doi.org/10.1007/s00221-005-2228-7

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