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Published in: Osteoporosis International 11/2022

Open Access 02-08-2022 | Distal Radius Fracture | Original Article

Hospitalizations for major osteoporotic fractures in Switzerland: a long-term trend analysis between 1998 and 2018

Authors: Kurt Lippuner, Gergana Rimmer, Anna K. Stuck, Patrick Schwab, Oliver Bock

Published in: Osteoporosis International | Issue 11/2022

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Abstract

Summary

Between 1998 and 2018, the number of hospitalizations for major osteoporotic fractures increased. After standardization for age, these numerical increases translated into a reduced incidence of hospitalizations for hip fractures and an increased incidence of hospitalizations for spine, proximal humerus, and distal radius fractures in both sexes.

Introduction

The longterm epidemiological trends of hospitalizations for major osteoporotic fractures (MOF) between 1998 and 2018 in Switzerland are unknown.

Methods

The absolute number of acute hospitalizations for MOF (hip fractures and fractures of the spine, proximal humerus, and distal radius) and related length of acute hospital stay were extracted from the medical database of the Swiss Federal Office of Statistics. Age-standardized incidence rates were calculated using 1998 as the reference year.

Results

Hospitalizations for MOF increased from 4483 to 7542 (+ 68.2%) in men and from 13,242 to 19,362 (+ 46.2%) in women. The age-standardized incidence of hospitalizations for MOF increased by 5.7% in men (p = 0.002) and by 5.1% in women (p = 0.018). The age-standardized incidence of hip fractures decreased by 15.3% in men (p < 0.001) and by 21.5% in women (p < 0.001). In parallel, the age-standardized incidence of MOF other than hip fractures increased by 31.8% in men (p < 0.001) and by 40.1% in women (p < 0.001). The mean length of acute hospital stays for MOF decreased from 16.3 to 8.5 days in men and from 16.9 to 8.1 days in women.

Conclusion

Between 1998 and 2018, the number of hospitalizations for MOF increased significantly by a larger extent than expected based on the ageing of the Swiss population alone. This increase was solely driven by an increased incidence of MOF other than hip fractures as incident hip fractures decreased over time in both sexes, more so in women than in men.
Literature
1.
go back to reference (1993) Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94:646–650 (1993) Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94:646–650
2.
go back to reference Kanis JA, Cooper C, Rizzoli R, Reginster JY, Scientific Advisory Board of the European Society for C, Economic Aspects of O, the Committees of Scientific A, National Societies of the International Osteoporosis F (2019) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 30:3–44CrossRef Kanis JA, Cooper C, Rizzoli R, Reginster JY, Scientific Advisory Board of the European Society for C, Economic Aspects of O, the Committees of Scientific A, National Societies of the International Osteoporosis F (2019) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 30:3–44CrossRef
3.
go back to reference Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, Rizzoli R, European Society for C, Economic Aspects of O, Osteoarthritis (2008) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 19:399–428CrossRef Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, Rizzoli R, European Society for C, Economic Aspects of O, Osteoarthritis (2008) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 19:399–428CrossRef
4.
go back to reference Lippuner K, Popp AW, Schwab P, Gitlin M, Schaufler T, Senn C, Perrelet R (2011) Fracture hospitalizations between years 2000 and 2007 in Switzerland: a trend analysis. Osteoporos Int 22:2487–2497CrossRef Lippuner K, Popp AW, Schwab P, Gitlin M, Schaufler T, Senn C, Perrelet R (2011) Fracture hospitalizations between years 2000 and 2007 in Switzerland: a trend analysis. Osteoporos Int 22:2487–2497CrossRef
5.
go back to reference Oden A, McCloskey EV, Kanis JA, Harvey NC, Johansson H (2015) Burden of high fracture probability worldwide: secular increases 2010–2040. Osteoporos Int 26:2243–2248CrossRef Oden A, McCloskey EV, Kanis JA, Harvey NC, Johansson H (2015) Burden of high fracture probability worldwide: secular increases 2010–2040. Osteoporos Int 26:2243–2248CrossRef
6.
go back to reference Ballane G, Cauley JA, Luckey MM, Fuleihan Gel H (2014) Secular trends in hip fractures worldwide: opposing trends East versus West. J Bone Miner Res 29:1745–1755CrossRef Ballane G, Cauley JA, Luckey MM, Fuleihan Gel H (2014) Secular trends in hip fractures worldwide: opposing trends East versus West. J Bone Miner Res 29:1745–1755CrossRef
7.
go back to reference Pekonen SR, Kopra J, Kroger H, Rikkonen T, Sund R (2021) Regional and gender-specific analyses give new perspectives for secular trend in hip fracture incidence. Osteoporos Int 32:1725–1733CrossRef Pekonen SR, Kopra J, Kroger H, Rikkonen T, Sund R (2021) Regional and gender-specific analyses give new perspectives for secular trend in hip fracture incidence. Osteoporos Int 32:1725–1733CrossRef
8.
go back to reference Kanis JA, Norton N, Harvey NC, Jacobson T, Johansson H, Lorentzon M, McCloskey EV, Willers C, Borgstrom F (2021) SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos 16:82CrossRef Kanis JA, Norton N, Harvey NC, Jacobson T, Johansson H, Lorentzon M, McCloskey EV, Willers C, Borgstrom F (2021) SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos 16:82CrossRef
9.
go back to reference Dimai HP, Reichardt B, Zitt E, Concin H, Malle O, Fahrleitner-Pammer A, Svedbom A, Brozek W (2022) Thirty years of hip fracture incidence in Austria: is the worst over? Osteoporos Int 33:97–104CrossRef Dimai HP, Reichardt B, Zitt E, Concin H, Malle O, Fahrleitner-Pammer A, Svedbom A, Brozek W (2022) Thirty years of hip fracture incidence in Austria: is the worst over? Osteoporos Int 33:97–104CrossRef
10.
go back to reference Dimai HP, Svedbom A, Fahrleitner-Pammer A, Pieber T, Resch H, Zwettler E, Chandran M, Borgstrom F (2011) Epidemiology of hip fractures in Austria: evidence for a change in the secular trend. Osteoporos Int 22:685–692CrossRef Dimai HP, Svedbom A, Fahrleitner-Pammer A, Pieber T, Resch H, Zwettler E, Chandran M, Borgstrom F (2011) Epidemiology of hip fractures in Austria: evidence for a change in the secular trend. Osteoporos Int 22:685–692CrossRef
11.
go back to reference Garofoli R, Maravic M, Ostertag A, Cohen-Solal M (2019) Secular trends of hip fractures in France: impact of changing characteristics of the background population. Osteoporos Int 30:355–362CrossRef Garofoli R, Maravic M, Ostertag A, Cohen-Solal M (2019) Secular trends of hip fractures in France: impact of changing characteristics of the background population. Osteoporos Int 30:355–362CrossRef
12.
go back to reference Hemmann P, Friederich M, Korner D, Klopfer T, Bahrs C (2021) Changing epidemiology of lower extremity fractures in adults over a 15-year period — a National Hospital Discharge Registry study. BMC Musculoskelet Disord 22:456CrossRef Hemmann P, Friederich M, Korner D, Klopfer T, Bahrs C (2021) Changing epidemiology of lower extremity fractures in adults over a 15-year period — a National Hospital Discharge Registry study. BMC Musculoskelet Disord 22:456CrossRef
13.
go back to reference Dimai HP, Svedbom A, Fahrleitner-Pammer A, Resch H, Muschitz C, Thaler H, Szivak M, Amrein K, Borgstrom F (2014) Epidemiology of distal forearm fractures in Austria between 1989 and 2010. Osteoporos Int 25:2297–2306CrossRef Dimai HP, Svedbom A, Fahrleitner-Pammer A, Resch H, Muschitz C, Thaler H, Szivak M, Amrein K, Borgstrom F (2014) Epidemiology of distal forearm fractures in Austria between 1989 and 2010. Osteoporos Int 25:2297–2306CrossRef
14.
go back to reference Dimai HP, Svedbom A, Fahrleitner-Pammer A, Pieber T, Resch H, Zwettler E, Thaler H, Szivak M, Amrein K, Borgstrom F (2013) Epidemiology of proximal humeral fractures in Austria between 1989 and 2008. Osteoporos Int 24:2413–2421CrossRef Dimai HP, Svedbom A, Fahrleitner-Pammer A, Pieber T, Resch H, Zwettler E, Thaler H, Szivak M, Amrein K, Borgstrom F (2013) Epidemiology of proximal humeral fractures in Austria between 1989 and 2008. Osteoporos Int 24:2413–2421CrossRef
16.
go back to reference Svedbom A, Ivergard M, Hernlund E, Rizzoli R, Kanis JA (2014) Epidemiology and economic burden of osteoporosis in Switzerland. Arch Osteoporos 9:187CrossRef Svedbom A, Ivergard M, Hernlund E, Rizzoli R, Kanis JA (2014) Epidemiology and economic burden of osteoporosis in Switzerland. Arch Osteoporos 9:187CrossRef
19.
go back to reference Chevalley T, Guilley E, Herrmann FR, Hoffmeyer P, Rapin CH, Rizzoli R (2007) Incidence of hip fracture over a 10-year period (1991–2000): reversal of a secular trend. Bone 40:1284–1289CrossRef Chevalley T, Guilley E, Herrmann FR, Hoffmeyer P, Rapin CH, Rizzoli R (2007) Incidence of hip fracture over a 10-year period (1991–2000): reversal of a secular trend. Bone 40:1284–1289CrossRef
20.
go back to reference Guilley E, Chevalley T, Herrmann F, Baccino D, Hoffmeyer P, Rapin CH, Rizzoli R (2008) Reversal of the hip fracture secular trend is related to a decrease of the incidence in institutional-dwelling elderly women. Osteoporos Int 19:1741–1747CrossRef Guilley E, Chevalley T, Herrmann F, Baccino D, Hoffmeyer P, Rapin CH, Rizzoli R (2008) Reversal of the hip fracture secular trend is related to a decrease of the incidence in institutional-dwelling elderly women. Osteoporos Int 19:1741–1747CrossRef
22.
go back to reference Lewinnek GE, Kelsey J, White AA, 3rd, Kreiger NJ (1980) The significance and a comparative analysis of the epidemiology of hip fractures. Clin Orthop Relat Res 152:35-43 Lewinnek GE, Kelsey J, White AA, 3rd, Kreiger NJ (1980) The significance and a comparative analysis of the epidemiology of hip fractures. Clin Orthop Relat Res 152:35-43
23.
go back to reference Hemmann P, Ziegler P, Konrads C, Ellmerer A, Klopfer T, Schreiner AJ, Bahrs C (2020) Trends in fracture development of the upper extremity in Germany—a population-based description of the past 15 years. J Orthop Surg Res 15:65CrossRef Hemmann P, Ziegler P, Konrads C, Ellmerer A, Klopfer T, Schreiner AJ, Bahrs C (2020) Trends in fracture development of the upper extremity in Germany—a population-based description of the past 15 years. J Orthop Surg Res 15:65CrossRef
24.
go back to reference Suhm N, Lamy O, Lippuner K (2008) Management of fragility fractures in Switzerland: results of a nationwide survey. Swiss Med Wkly 138:674–683PubMed Suhm N, Lamy O, Lippuner K (2008) Management of fragility fractures in Switzerland: results of a nationwide survey. Swiss Med Wkly 138:674–683PubMed
25.
go back to reference Lippuner K, Johansson H, Kanis JA, Rizzoli R (2009) Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. Osteoporos Int 20:1131–1140CrossRef Lippuner K, Johansson H, Kanis JA, Rizzoli R (2009) Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. Osteoporos Int 20:1131–1140CrossRef
26.
go back to reference Parreira PCS, Maher CG, Megale RZ, March L, Ferreira ML (2017) An overview of clinical guidelines for the management of vertebral compression fracture: a systematic review. Spine J 17:1932–1938CrossRef Parreira PCS, Maher CG, Megale RZ, March L, Ferreira ML (2017) An overview of clinical guidelines for the management of vertebral compression fracture: a systematic review. Spine J 17:1932–1938CrossRef
27.
go back to reference Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D (2019) Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society* Clinical Practice Guideline. J Clin Endocrinol Metab 104:1595–1622CrossRef Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D (2019) Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society* Clinical Practice Guideline. J Clin Endocrinol Metab 104:1595–1622CrossRef
28.
go back to reference Cummings SR, San Martin J, McClung MR et al (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361:756–765CrossRef Cummings SR, San Martin J, McClung MR et al (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361:756–765CrossRef
29.
go back to reference Alswat KA (2017) Gender Disparities in Osteoporosis. J Clin Med Res 9:382–387CrossRef Alswat KA (2017) Gender Disparities in Osteoporosis. J Clin Med Res 9:382–387CrossRef
30.
go back to reference Cawthon PM (2011) Gender differences in osteoporosis and fractures. Clin Orthop Relat Res 469:1900–1905CrossRef Cawthon PM (2011) Gender differences in osteoporosis and fractures. Clin Orthop Relat Res 469:1900–1905CrossRef
31.
go back to reference Kanis JA, Johansson H, Oden A et al (2018) Characteristics of recurrent fractures. Osteoporos Int 29:1747–1757CrossRef Kanis JA, Johansson H, Oden A et al (2018) Characteristics of recurrent fractures. Osteoporos Int 29:1747–1757CrossRef
Metadata
Title
Hospitalizations for major osteoporotic fractures in Switzerland: a long-term trend analysis between 1998 and 2018
Authors
Kurt Lippuner
Gergana Rimmer
Anna K. Stuck
Patrick Schwab
Oliver Bock
Publication date
02-08-2022
Publisher
Springer London
Published in
Osteoporosis International / Issue 11/2022
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-022-06481-0

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