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Osteoporosis International

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01-10-2015 | Original Article

Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial

Authors: L. M. Cangussu, J. Nahas-Neto, C. L. Orsatti, F. N. Bueloni-Dias, E. A. P. Nahas

Published in: Osteoporosis International | Issue 10/2015

Abstract

Summary

The present study investigates the effects of vitamin D on muscle function in postmenopausal women. It has been shown that vitamin D supplementation in postmenopausal women with hypovitaminosis D provides significant protective factor against sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass.

Introduction

We aimed to evaluate the effect of supplementation of vitamin D (VITD) alone on muscle function in younger postmenopausal women.

Methods

In this double-blind, placebo-controlled clinical trial, 160 Brazilian postmenopausal women were randomized into two groups: VITD group consisting of patients receiving vitamin D3 1000 IU/day orally (n = 80) or placebo group (n = 80). Women with amenorrhea for more than 12 months and age 50–65 years, with a history of falls (previous 12 months), were included. The intervention time was 9 months, with assessments at two points, start and end. Lean mass was estimated by total-body dual-energy X-ray absorptiometry (DXA) and muscle strength by handgrip strength and chair rising test. The plasma concentrations of 25-hydroxyvitamin D [25(OH)D] were measured by high-performance liquid chromatography (HPLC). Statistical analysis was by intention to treat (ITT), using ANOVA, Student’s t test, and Tukey’s test.

Results

After 9 months, average values of 25(OH)D increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/ml (+45.4 %) in the VITD group and decreased from 16.9 ± 6.7 to 13.8 ± 6.0 ng/ml (−18.5 %) in the placebo group (p < 0.001). In the VITD group, there was significant increase in muscle strength (+25.3 %) of the lower limbs by chair rising test (p = 0.036). In women in the placebo group, there was considerable loss (−6.8 %) in the lean mass (p = 0.030).

Conclusion

The supplementation of vitamin D alone in postmenopausal women provided significant protective factor against the occurrence of sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass.

Sirola J, Rikkonen T (2005) Muscle performance after the menopause. J Br Menopause Soc 11:45–50CrossRefPubMed

Orsatti FL, Nahas EAP, Nahas-Neto J, Orsatti CL, Marocolo M, Barbosa-Neto O, da Mota GR (2011) Low appendicular muscle mass is correlated with femoral neck bone mineral density loss in postmenopausal women. BMC Musculoskelet Disord 12:225PubMedCentralCrossRefPubMed

Muir SW, Montero-Odasso M (2011) Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 59:2291–2300CrossRefPubMed

Cangussu LM, Nahas-Neto J, Petri Nahas EA, Rodrigues Barral AD, de Araujo Buttros D, Uemura G (2012) Evaluation of postural balance in postmenopausal women and its relationship with bone mineral density—a cross sectional study. BMC Musculoskelet Disord 13:2–8PubMedCentralCrossRefPubMed

Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan van Kan G, Andrieu S, Bauer J, Breuille D (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International Working Group on Sarcopenia. J Am Med Dir Assoc 12:249–256CrossRefPubMed

Ribeiro SM, Kehayias JJ (2014) Sarcopenia and the analysis of body composition. Adv Nutr 5:260–267PubMedCentralCrossRefPubMed

Barrett-Cornor E, Weiss TW, McHorney CA, Miller PD, Siris ES (2009) Predictors of falls among postmenopausal women: results from the National Osteoporosis Risk Assessment. Osteoporos Int 20:715–722CrossRef

Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, Pierroz DD, Weber P, Hoffmann K (2014) A systematic review of vitamin D status in populations worldwide. Br J Nutr 111:23–45CrossRefPubMed

Lips P, Hosking K, Lipunner K, Norquist JM, Wehren L, Maalouf G, Ragi-Eis S, Chandler J (2006) The prevalence of vitamin D inadequacy amongst women 25OHD with osteoporosis: an international epidemiological investigation. J Intern Med 260:245–254CrossRefPubMed

10.

Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281CrossRefPubMed

11.

Unger MD, Cuppari L, Titan SM, Magalhães MC, Sassaki AL, dos Reis LM, Jorgetti V, Moysés RM (2010) Vitamin D status in a sunny country: where has the sun gone? Clin Nutr 29:784–788CrossRefPubMed

12.

Ceglia L, Niramitmahapanya S, da Silva Morais M, Rivas DA, Harris SS, Bischoff-Ferrari H, Fielding RA, Dawson-Hughes B (2013) A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab 98:1927–1935CrossRef

13.

Bergman GJ, Fan T, McFetridge JT, Sen SS (2010) Efficacy of vitamin D3 supplementation in preventing fractures in elderly women: a meta-analysis. Curr Med Res Opin 26:1193–1201CrossRefPubMed

14.

Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J (2009) Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomized controlled trials. BMJ 339:3692–3698CrossRef

15.

Barr R, Macdonald H, Stewart A, McGuigan F, Rogers A, Eastell R, Felsenberg D, Glüer C, Roux C, Reid DM (2010) Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies [APOSS and OPUS]. Osteoporos Int 21:457–466CrossRefPubMed

16.

Bischoff HA, Stahelin HB, Dick W, Akos R, Knecht M, Salis C, Nebiker M, Theiler R, Pfeifer M, Begerow B, Lew RA, Conzelmann M (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351CrossRefPubMed

17.

Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ (2004) Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 33:589–595CrossRefPubMed

18.

Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H (2009) Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 20:315–322CrossRefPubMed

19.

Rejnmark L (2011) Effects of vitamin D on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis 2:25–37PubMedCentralCrossRefPubMed

20.

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) (2002) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106:143–421CrossRef

21.

Baumgartner TA, Jackson AS (1995) Measurement for evaluation in physical education and exercise science. WCB Brown and Benchmark, Madison

22.

Kiebzak GM, Leamy LJ, Pierson LM, Nord RH, Zhang ZY (2000) Measurement precision of body composition variables using the lunar DPX-L densitometer. J Clin Densitom 3:35–41CrossRefPubMed

23.

Petak S, Barbu CG, Yu EW, Fielding R, Mulligan K, Sabowitz B, Wu CH, Shepherd JA (2013) The official positions of the International Society for Clinical Densitometry: body composition analysis reporting. J Clin Densitom 16:508–519CrossRefPubMed

24.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older People (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423PubMedCentralCrossRefPubMed

25.

Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B (2006) Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 84:18–28PubMed

26.

Jackson C, Gaugris S, Sen SS, Hoshing D (2007) The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis. QJM 100:185–192CrossRefPubMed

27.

Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80:1678S–1688SPubMed

28.

Lips P (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22(4):477–501CrossRefPubMed

29.

Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, Dawson-Hughes B (2004) Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or = 60 y. Am J Clin Nutr 80:752–758PubMed

30.

Dawson-Hughes B (2012) Serum 25-hydroxyvitamin D and muscle atrophy in the elderly. Proc Nutr Soc 71:46–49CrossRefPubMed

31.

Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE (2013) The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev 34:33–38CrossRefPubMed

32.

Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J (2009) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 169:551–561CrossRefPubMed

33.

Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, Yoshimura N (2010) IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21:1151–1154CrossRefPubMed

34.

Pérez-López FR, Brincat M, Erel T, Tremollieres F, Gambacciani M, Lambrinoudaki I, Moen MH, Schenck-Gustafsson K, Vujovic S, Rozenberg S, Rees M (2012) EMAS position statement: vitamin D and postmenopausal health. Maturitas 71:83–88CrossRefPubMed

35.

Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal Z (2009) Vitamin D status and muscle function in post menarchal adolescent girls. J Clin Endocrinol Metab 94:559–563CrossRefPubMed

36.

Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stähelin HB, Dick W (2001) In situ detection of 1,25-dihydroxyvitamin D receptor in human skeletal muscle tissue. Histochem J 33:19–24CrossRefPubMed

37.

Moreira-Pfrimer LDF, Pedrosa MAC, Teixeira L, Lazaretti-Castro M (2009) Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab 54:291–300CrossRefPubMed

38.

Zhu K, Austin N, Devine A, Bruce D, Prince RL (2010) A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. J Am Geriatr Soc 58:2063–2068CrossRefPubMed

39.

Bischoff-Ferrari HA, Dawson-Hughes B, Stocklin E, Stöcklin E, Sidelnikov E, Willett WC, Edel JO, Stähelin HB, Wolfram S, Jetter A, Schwager J, Henschkowski J, von Eckardstein A, Egli A (2012) Oral supplementation with 25[OH]D3 versus vitamin D3: effects on 25[OH]D levels, lower extremity function, blood pressure, and markers of innate immunity. J Bone Miner Res 27:160–169CrossRefPubMed

40.

Janssen HC, Samson MM, Verhaar HJ (2010) Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation. Aging Clin Exp Res 22:78–84CrossRefPubMed

41.

Annweiler C, Beauchet O, Berrut G, Fantino B, Bonnefoy M, Herrmann FR, Schott AM (2009) Is there an association between serum 25-hydroxyvitamin D concentration and muscle strength among older women? Results from baseline assessment of the EPIDOS study. J Nutr Health Aging 3:90–95CrossRef

42.

Beaudart C, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J, Petermans J, Reginster JY, Bruyère O (2014) The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 99:4336–4345CrossRefPubMed

43.

Ford L (2013) Measurement of vitamin D. Methods Mol Biol 1065:245–257CrossRefPubMed

Title: Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial
Authors: L. M. Cangussu
J. Nahas-Neto
C. L. Orsatti
F. N. Bueloni-Dias
E. A. P. Nahas
Publication date: 01-10-2015
Publisher: Springer London
Published in: Osteoporosis International / Issue 10/2015
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-015-3151-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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