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Osteoporosis International

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01-10-2014 | Original Article

Osteoporosis as an independent risk factor for silent brain infarction and white matter changes in men and women: the PRESENT project

Authors: Y. K. Minn, S. H. Suk, S. Y. Do

Published in: Osteoporosis International | Issue 10/2014

Abstract

Summary

Previous studies have not demonstrated a relationship between osteoporosis and cerebral infarction in the community, especially in men. We found that osteoporosis may be an independent risk factor for brain white matter change/silent infarction in men, as well as in women.

Purpose

We aimed to study the relationship between low bone mineral density (BMD) and brain white matter changes and/or silent infarcts (WMC/SI).

Methods

This was a community-based, cross-sectional study supported by the regional government. Bone mineral density measurements and brain computed tomography were performed in 646 stroke- and dementia-free subjects (aged 50–75 years).

Results

After adjustment for age, hypertension, diabetes mellitus, dyslipidemia, and current smoking status, the odds ratio (OR) of risk for WMC and/or SI was 1.8 in the osteopenia group (95 % confidence interval [CI] 1.15–2.77; P = 0.01) and 2.2 in the osteoporosis group (95 % CI 1.42–3.55; P < 0.001). Among men, the OR was 1.8 (95 % CI 0.72–4.62; P = 0.21) and 3.8 (95 % CI 1.63–8.86; P = 0.002), and in women, the OR was 1.9 (95 % CI 1.15–2.78; P = 0.010) and 2.2 (95 % CI 1.42–3.55; P = 0.001), respectively.

Conclusions

Severe bone mass loss may be an independent risk factor for brain WMC/SI in men and women. Low BMD may cause brain WMC/SI in the step that leads to stroke. Although there are well-designed studies on the prevention of cerebral infarction in patients with brain WMC/SI, a specific prevention method, such as aspirin, should be used for patients with low BMD who have WMC/SI. Screening for low BMD as an independent vascular risk factor in healthy subjects may be required to prevent stroke.

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Title: Osteoporosis as an independent risk factor for silent brain infarction and white matter changes in men and women: the PRESENT project
Authors: Y. K. Minn
S. H. Suk
S. Y. Do
Publication date: 01-10-2014
Publisher: Springer London
Published in: Osteoporosis International / Issue 10/2014
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-014-2785-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Osteoporosis as an independent risk factor for silent brain infarction and white matter changes in men and women: the PRESENT project

Abstract

Summary

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Purpose

Methods

Results

Conclusions

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