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Osteoporosis International

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01-03-2012 | Original Article

Prevalence of non-fracture short vertebral height is similar in premenopausal and postmenopausal women: the osteoporosis and ultrasound study

Authors: L. Ferrar, C. Roux, D. M. Reid, D. Felsenberg, C. C. Glüer, R. Eastell

Published in: Osteoporosis International | Issue 3/2012

Abstract

Summary

We observed similar prevalence of short vertebral height without endplate depression (SVH) in young women aged 20–39 years and older women aged 55–79 years. There was no association between SVH and low bone density. In older women, therefore, SVH may be largely long standing and not indicative of osteoporotic fracture.

Introduction

Algorithm-based qualitative (ABQ) definition of osteoporotic vertebral fracture (VF) requires evidence of endplate fracture, and there is no minimum threshold for apparent ‘reduction’ in vertebral height. In older women, SVH without endplate fracture identified on baseline assessment may be long standing and unrelated to VF. If this is so, we would expect to see a similar prevalence of SVH in younger women. We aimed to compare the prevalence of pre- and postmenopausal women with SVH and the characteristics of women with and without SVH.

Methods

We used the ABQ method to classify baseline vertebral images (DXA-based imaging) from 257 premenopausal and 1,361 postmenopausal women participating in the population-based Osteoporosis and Ultrasound Study. Images were classified as follows: normal (no VF, no SVH), SVH (no VF) or VF (with/without SVH in unfractured vertebrae). We compared proportions of women with SVH (chi-squared test) and compared age, height, weight and bone mineral density (BMD) by ABQ classification (two-sample t test/analysis of variance).

Results

The prevalence of pre- and postmenopausal women with SVH was 37% and 33%, respectively (P>0.05). Compared to women without SVH, premenopausal women with SVH were older (P<0.001) and heavier (P=0.05), and postmenopausal women with SVH were taller (P<0.05), with higher spine BMD (P<0.01). Postmenopausal women with VF were older (P<0.001) and shorter (P<0.01) with lower BMD (P<0.001) than women without VF.

Conclusions

Short vertebral height without endplate fracture is equally prevalent in pre- and postmenopausal women and not associated with low bone density.

Jiang G, Eastell R, Barrington NA, Ferrar L (2004) Comparison of methods for the visual identification of prevalent vertebral fracture in osteoporosis. Osteoporos Int 15(11):887–896PubMedCrossRef

Ferrar L, Jiang G, Armbrecht G, Reid DM, Roux C, Glüer CC, Felsenberg D, Eastell R (2007) Is short vertebral height always an osteoporotic fracture? The Osteoporosis and Ultrasound Study (OPUS). Bone 1:5–12CrossRef

Ferrar L, Jiang G, Cawthon PM, San Valentin R, Fullman R, Lambert L, Cummings SR, Black DM, Orwoll E, Barrett-Connor E, Ensrud K, Fink HA, Eastell R (2007) Identification of vertebral fracture and non-osteoporotic short vertebral height in men: the MrOS study. J Bone Miner Res 22(9):1434–1441PubMedCrossRef

Blake GM, Rea JA, Fogelman I (1997) Vertebral morphometry studies using dual-energy x-ray absorptiometry. Semin Nucl Med 27:276–290PubMedCrossRef

Glüer CC, Eastell R, Reid DM, Felsenberg D, Roux C, Barkmann R, Timm W, Blenk T, Armbrecht G, Stewart A, Clowes J, Thomasius FE, Kolta S (2004) Association of five quantitative ultrasound devices and bone densitometry with osteoporotic vertebral fractures in a population-based sample: the OPUS study. JBMR 19:782–793CrossRef

Schousboe JT, Vokes T, Broy SB, Ferrar L, McKiernan F, Roux C, Binkley N (2008) Vertebral fracture assessment: the 2007 ISCD official positions. J Clin Densitom 11(1):92–108PubMedCrossRef

Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res Sep 8(9):1137–1148CrossRef

Grigoryan M, Guermazi A, Roemer FW, Delmas PD, Genant HK (2003) Recognizing and reporting osteoporotic vertebral fractures. Eur Spine J 12(Suppl 2):S104–S112PubMedCrossRef

Hedlund LR, Gallagher JC (1988) Vertebral morphometry in diagnosis of spinal fractures. Bone Miner 5(1):59–67PubMedCrossRef

10.

Diacinti D, Acca M, D’Erasmo E, Tomei E, Mazzuoli GF (1995) Aging changes in vertebral morphometry. Calcif Tissue Int 57(6):426–429PubMedCrossRef

11.

Davies KM, Recker RR, Heaney RP (1989) Normal vertebral dimensions and normal variation in serial measurements of vertebrae. J Bone Miner Res 4(3):341–349PubMedCrossRef

12.

Rühli FJ, Müntener M, Henneberg M (2005) Age-dependent changes of the normal human spine during adulthood. Am J Hum Biol 17:460–469PubMedCrossRef

13.

Vernon-Roberts B, Pirie CJ (1977) Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae. Rheumatol Rehabil 16:13–21PubMedCrossRef

14.

Shao Z, Rompe G, Schiltenwolf M (2002) Radiographic changes in the lumbar intervertebral discs and lumbar vertebrae with age. Spine 27:263–268PubMedCrossRef

15.

Amonoo-Kuofi HS (1991) Morphometric changes in the heights and anteroposterior diameters of the lumbar intervertebral discs with age. J Anat 175:159–168PubMed

16.

Twomey LT, Taylor JR (1985) Age changes in lumbar intervertebral discs. Acta Orthop Scand 56:97–104

17.

Evans SF, Nicholson PH, Haddaway MJ et al (1993) Vertebral morphometry in women aged 50–81 years. Bone Miner 21:29–40PubMedCrossRef

18.

Pollintine P, Luo J, Offa-Jones B, Dolan P, Adams MA (2009) Bone creep can cause progressive vertebral deformity. Bone 45:466–472PubMedCrossRef

19.

Takatalo J, Karppinen J, Niinimäki J, Taimela S, Näyhä S, Järvelin MR, Kyllönen E, Tervonen O (2009) Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults. Spine (Phila Pa 1976) 34:1716–1721CrossRef

20.

Powell MC, Wilson M, Szypryt P, Symonds EM, Worthington BS (1986) Prevalence of lumbar disc degeneration observed by magnetic resonance in symptomless women. Lancet 13:1366–1367CrossRef

21.

Jenssen KK, Tougaard L (1981) A simple x-ray method for monitoring progress of osteoporosis. Lancet 2:19–20CrossRef

Title: Prevalence of non-fracture short vertebral height is similar in premenopausal and postmenopausal women: the osteoporosis and ultrasound study
Authors: L. Ferrar
C. Roux
D. M. Reid
D. Felsenberg
C. C. Glüer
R. Eastell
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 3/2012
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-011-1657-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prevalence of non-fracture short vertebral height is similar in premenopausal and postmenopausal women: the osteoporosis and ultrasound study

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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