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01-05-2011 | Original Article

25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates

Authors: L. S. Greene-Finestone, C. Berger, M. de Groh, D. A. Hanley, N. Hidiroglou, K. Sarafin, S. Poliquin, J. Krieger, J. B. Richards, D. Goltzman, CaMos Research Group

Published in: Osteoporosis International | Issue 5/2011

Abstract

Summary

We assessed vitamin D status and its correlates in the population-based Canadian Multicentre Osteoporosis Study (CaMos). Results showed that serum 25-hydroxyvitamin D levels <75 nmol/L were common. Given Canada’s high latitude, attention should be given to strategies for enhancing vitamin D status in the population.

Introduction

Inadequate vitamin D has been implicated as a risk factor for several clinical disorders. We assessed, in a Canadian cohort, vitamin D status and its correlates, based on serum 25-hydroxyvitamin D [25(OH)D], the best functional indicator of vitamin D status.

Methods

We studied 577 men and 1,335 women 35+ years from seven cities across Canada in the randomly selected, population-based Canadian Multicentre Osteoporosis Study (CaMos). Participants completed a comprehensive questionnaire. Serum 25(OH)D was measured by immunoassay. Multivariate linear regression modeling assessed the association between 25(OH)D and determinants of vitamin D status.

Results

Participants (2.3%) were deficient in 25(OH)D (<27.5 nmol/L); a further 18.1% exhibited 25(OH)D insufficiency (27.5–50 nmol/L). Levels <75 nmol/L were evident in 57.5% of men and 60.7% of women and rose to 73.5% in spring (men) and 77.5% in winter (women); 25(OH)D <50 nmol/L was ≤10% year round for those supplementing with ≥400 IU vitamin D/day but was 43.9% among those not supplementing in winter and spring. The strongest predictors of reduced 25(OH)D for both men and women were winter and spring season, BMI ≥30, non-white ethnicity, and lower vitamin D supplementation and its modification by fall and winter.

Conclusions

In this national Canadian cohort, vitamin D levels <75 nmol/L were common, particularly among non-white and obese individuals, and in winter and spring. Vitamin D intake through diet and supplementation and maintenance of normal weight are key modifiable factors for enhancing vitamin D status and thus potentially influencing susceptibility to common chronic diseases.

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Title: 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates
Authors: L. S. Greene-Finestone
C. Berger
M. de Groh
D. A. Hanley
N. Hidiroglou
K. Sarafin
S. Poliquin
J. Krieger
J. B. Richards
D. Goltzman
CaMos Research Group
Publication date: 01-05-2011
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 5/2011
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-010-1362-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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