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Published in: Osteoporosis International 9/2010

01-09-2010 | Original Article

Effects of a 1-year randomized controlled trial of resistance training on lower limb bone and muscle structure and function in older men

Authors: J. Whiteford, T. R. Ackland, S. S. Dhaliwal, A. P. James, J. J. Woodhouse, R. Price, R. L. Prince, D. A. Kerr

Published in: Osteoporosis International | Issue 9/2010

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Abstract

Summary

A 1-year randomized controlled trial of resistance training compared with a control group was undertaken in 143 men aged 55–80 years. Although hip bone mineral density, lean body mass, and function increased in both groups, lean body mass and function but not bone density increased more in the resistance group.

Introduction

Previous studies have demonstrated a positive effect of resistance training on bone mineral density (BMD) in postmenopausal women, but the effect in men is unclear. The aim was to examine the effect of a 1-year resistance training program on bone and lean body mass in 143 men aged 55–80 years, randomized to either resistance training or active control.

Methods

Resistance exercises were selected to provide loading at the hips. Measurements were taken at 0, 6, and 12 months for BMD (whole body, hip, and spine), lean body mass, strength, and functional fitness.

Results

The intervention showed a significant increase in total hip BMD for both groups at 12 months (active control, 1,014–1,050 mg/cm2; resistance, 1,045–1,054 mg/cm2, p < 0.05) with no increased effect of resistance training compared to active control. However, compared to the active control group, the resistance group increased their lean body mass (active control, 0.1 ± 2.1%; resistance, 1.5 ± 2.7%, p < 0.05), fitness (active control, 4.6 ± 11.1%; resistance, 13.0 ± 13.4%, p < 0.05), and lower limb muscle strength (active control, 14.3 ± 16.8%; resistance, 39.4 ± 30.87%, p < 0.05).

Conclusions

In contrast to previous findings in older women, in older men, a resistance training program does not increase hip bone mass more than walking 30 min three times a week.
Literature
1.
go back to reference Chambers TJ, Evans M, Gardner TN, Turner-Smith A, Chow JW (1993) Induction of bone formation in rat tail vertebrae by mechanical loading. Bone Miner 20:167–178CrossRefPubMed Chambers TJ, Evans M, Gardner TN, Turner-Smith A, Chow JW (1993) Induction of bone formation in rat tail vertebrae by mechanical loading. Bone Miner 20:167–178CrossRefPubMed
2.
go back to reference Chow JW, Jagger CJ, Chambers TJ (1993) Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae. Am J Physiol 265:E340–E347PubMed Chow JW, Jagger CJ, Chambers TJ (1993) Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae. Am J Physiol 265:E340–E347PubMed
3.
go back to reference Turner CH, Robling AG (2005) Mechanisms by which exercise improves bone strength. J Bone Miner Metab 23(Suppl):16–22CrossRefPubMed Turner CH, Robling AG (2005) Mechanisms by which exercise improves bone strength. J Bone Miner Metab 23(Suppl):16–22CrossRefPubMed
4.
go back to reference Turner CH (2002) Biomechanics of bone: determinants of skeletal fragility and bone quality. Osteoporos Int 13:97–104CrossRefPubMed Turner CH (2002) Biomechanics of bone: determinants of skeletal fragility and bone quality. Osteoporos Int 13:97–104CrossRefPubMed
5.
go back to reference Warden SJ, Hurst JA, Sanders MS, Turner CH, Burr DB, Li J (2005) Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. J Bone Miner Res 20:809–816CrossRefPubMed Warden SJ, Hurst JA, Sanders MS, Turner CH, Burr DB, Li J (2005) Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. J Bone Miner Res 20:809–816CrossRefPubMed
6.
go back to reference Martin AD, Daniel M, Clarys JP, Marfell-Jones MJ (2003) Cadaver-assessed validity of anthropometric indicators of adipose tissue distribution. Int J Obes Relat Metab Disord 27:1052–1058CrossRefPubMed Martin AD, Daniel M, Clarys JP, Marfell-Jones MJ (2003) Cadaver-assessed validity of anthropometric indicators of adipose tissue distribution. Int J Obes Relat Metab Disord 27:1052–1058CrossRefPubMed
7.
go back to reference Schriefer JL, Warden SJ, Saxon LK, Robling AG, Turner CH (2005) Cellular accommodation and the response of bone to mechanical loading. J Biomech 38:1838–1845CrossRefPubMed Schriefer JL, Warden SJ, Saxon LK, Robling AG, Turner CH (2005) Cellular accommodation and the response of bone to mechanical loading. J Biomech 38:1838–1845CrossRefPubMed
8.
go back to reference Burr DB, Robling AG, Turner CH (2002) Effects of biomechanical stress on bones in animals. Bone 30:781–786CrossRefPubMed Burr DB, Robling AG, Turner CH (2002) Effects of biomechanical stress on bones in animals. Bone 30:781–786CrossRefPubMed
9.
go back to reference Lanyon LE, Rubin CT (1984) Static vs dynamic loads as an influence on bone remodelling. J Biomech 17:897–905CrossRefPubMed Lanyon LE, Rubin CT (1984) Static vs dynamic loads as an influence on bone remodelling. J Biomech 17:897–905CrossRefPubMed
10.
go back to reference Rubin CT, Lanyon LE (1985) Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 37:411–417CrossRefPubMed Rubin CT, Lanyon LE (1985) Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 37:411–417CrossRefPubMed
11.
go back to reference Frost HM (1990) Skeletal structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff’s law: the bone modeling problem. Anat Rec 226:403–413CrossRefPubMed Frost HM (1990) Skeletal structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff’s law: the bone modeling problem. Anat Rec 226:403–413CrossRefPubMed
12.
go back to reference Vuori I, Heinonen A, Sievanen H, Kannus P, Pasanen M, Oja P (1994) Effects of unilateral strength training and detraining on bone mineral density and content in young women: a study of mechanical loading and deloading on human bones. Calcif Tissue Int 55:59–67CrossRefPubMed Vuori I, Heinonen A, Sievanen H, Kannus P, Pasanen M, Oja P (1994) Effects of unilateral strength training and detraining on bone mineral density and content in young women: a study of mechanical loading and deloading on human bones. Calcif Tissue Int 55:59–67CrossRefPubMed
13.
go back to reference Snow-Harter C, Bouxsein ML, Lewis BT, Carter DR, Marcus R (1992) Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. J Bone Miner Res 7:761–769CrossRefPubMed Snow-Harter C, Bouxsein ML, Lewis BT, Carter DR, Marcus R (1992) Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. J Bone Miner Res 7:761–769CrossRefPubMed
14.
go back to reference Prince R, Devine A, Dick I, Criddle A, Kerr D, Kent N, Price R, Randell A (1995) The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Miner Res 10:1068–1075CrossRefPubMed Prince R, Devine A, Dick I, Criddle A, Kerr D, Kent N, Price R, Randell A (1995) The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Miner Res 10:1068–1075CrossRefPubMed
15.
go back to reference Lohman T, Going S, Pamenter R, Hall M, Boyden T, Houtkooper L, Ritenbaugh C, Bare L, Hill A, Aickin M (1995) Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 10:1015–1024CrossRefPubMed Lohman T, Going S, Pamenter R, Hall M, Boyden T, Houtkooper L, Ritenbaugh C, Bare L, Hill A, Aickin M (1995) Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 10:1015–1024CrossRefPubMed
16.
go back to reference Kerr D, Morton A, Dick I, Prince R (1996) Exercise effects on bone mass in postmenopausal women are site-specific and load-dependent. J Bone Miner Res 11:218–225CrossRefPubMed Kerr D, Morton A, Dick I, Prince R (1996) Exercise effects on bone mass in postmenopausal women are site-specific and load-dependent. J Bone Miner Res 11:218–225CrossRefPubMed
17.
go back to reference Kerr D, Ackland T, Maslen B, Morton A, Prince R (2001) Resistance training over 2 years increases bone mass in calcium-replete postmenopausal women. J Bone Miner Res 16:175–181CrossRefPubMed Kerr D, Ackland T, Maslen B, Morton A, Prince R (2001) Resistance training over 2 years increases bone mass in calcium-replete postmenopausal women. J Bone Miner Res 16:175–181CrossRefPubMed
18.
go back to reference Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ (1994) Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA 272:1909–1914CrossRefPubMed Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ (1994) Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA 272:1909–1914CrossRefPubMed
19.
go back to reference Nelson ME, Fisher EC, Dilmanian FA, Dallal GE, Evans WJ (1991) A 1-y walking program and increased dietary calcium in postmenopausal women: effects on bone. Am J Clin Nutr 53:1304–1311PubMed Nelson ME, Fisher EC, Dilmanian FA, Dallal GE, Evans WJ (1991) A 1-y walking program and increased dietary calcium in postmenopausal women: effects on bone. Am J Clin Nutr 53:1304–1311PubMed
20.
go back to reference Nieves JW, Formica C, Ruffing J, Zion M, Garrett P, Lindsay R, Cosman F (2005) Males have larger skeletal size and bone mass than females, despite comparable body size. J Bone Miner Res 20:529–535CrossRefPubMed Nieves JW, Formica C, Ruffing J, Zion M, Garrett P, Lindsay R, Cosman F (2005) Males have larger skeletal size and bone mass than females, despite comparable body size. J Bone Miner Res 20:529–535CrossRefPubMed
21.
go back to reference Corbin DE (2001) Exercise programming for older adults. In: Darcy P (ed) ACSM’s resource manual for guidelines for exercise testing and prescription. Lippincott Williams & Wilkins, Philadelphia, pp 529–536 Corbin DE (2001) Exercise programming for older adults. In: Darcy P (ed) ACSM’s resource manual for guidelines for exercise testing and prescription. Lippincott Williams & Wilkins, Philadelphia, pp 529–536
22.
go back to reference Corbin DE (2001) Exercise programming for older adults. Lippincott Williams & Wilkins, Philadelphia Corbin DE (2001) Exercise programming for older adults. Lippincott Williams & Wilkins, Philadelphia
23.
go back to reference (1999) Get healthy. Be active. Building a healthy, active Australia. In: National Physical Activity Guidelines for Adults. Department of Health and Aged Care, Australian Government (1999) Get healthy. Be active. Building a healthy, active Australia. In: National Physical Activity Guidelines for Adults. Department of Health and Aged Care, Australian Government
24.
go back to reference ISAK (2001) International Standards for Anthropometric Assessment. International Society for the Advancement of Kinanthopometry, Potchesfstroom, South Africa ISAK (2001) International Standards for Anthropometric Assessment. International Society for the Advancement of Kinanthopometry, Potchesfstroom, South Africa
25.
go back to reference Rikli RE, Jones JC (1999) Development and validation of a functional fitness test for community-residing older adults (Developpement et validation d ’ un test de condition physique fonctionnelle pour des personnes agees residant en maison de retraite). J Aging Phys Act 7:129–161 Rikli RE, Jones JC (1999) Development and validation of a functional fitness test for community-residing older adults (Developpement et validation d ’ un test de condition physique fonctionnelle pour des personnes agees residant en maison de retraite). J Aging Phys Act 7:129–161
26.
go back to reference Dennison E, Eastell R, Fall CDH, Kellingway S, Wood PJ, Cooper C (1999) Determinants of bone loss in elderly men and women: a prospective population-based study. Osteoporos Int 10:384–391CrossRefPubMed Dennison E, Eastell R, Fall CDH, Kellingway S, Wood PJ, Cooper C (1999) Determinants of bone loss in elderly men and women: a prospective population-based study. Osteoporos Int 10:384–391CrossRefPubMed
27.
go back to reference Nguyen ND, Center JR, Eisman JA, Nguyen TV (2007) Bone loss, weight loss, and weight fluctuation predict mortality risk in elderly men and women. J Bone Miner Res 22:1147–1154CrossRefPubMed Nguyen ND, Center JR, Eisman JA, Nguyen TV (2007) Bone loss, weight loss, and weight fluctuation predict mortality risk in elderly men and women. J Bone Miner Res 22:1147–1154CrossRefPubMed
28.
go back to reference Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA (1994) Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ 309:691–695PubMed Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA (1994) Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ 309:691–695PubMed
29.
go back to reference Grove KA, Londeree BR (1992) Bone density in postmenopausal women: high impact vs low impact exercise. Med Sci Sports Exerc 24:1190–1194PubMed Grove KA, Londeree BR (1992) Bone density in postmenopausal women: high impact vs low impact exercise. Med Sci Sports Exerc 24:1190–1194PubMed
30.
go back to reference Kerr DA (1996) The mechanical and morphometric determinants of bone density. The University of Western Australia, Perth, Department of Medicine Kerr DA (1996) The mechanical and morphometric determinants of bone density. The University of Western Australia, Perth, Department of Medicine
31.
go back to reference Kukuljan S, Nowson CA, Bass SL, Sanders K, Nicholson GC, Seibel MJ, Salmon J, Daly RM (2009) Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial. Osteoporos Int 20:1241–1251CrossRefPubMed Kukuljan S, Nowson CA, Bass SL, Sanders K, Nicholson GC, Seibel MJ, Salmon J, Daly RM (2009) Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial. Osteoporos Int 20:1241–1251CrossRefPubMed
32.
go back to reference Nguyen TV, Eisman JA, Kelly PJ, Sambrook PN (1996) Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol 144:255–263PubMed Nguyen TV, Eisman JA, Kelly PJ, Sambrook PN (1996) Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol 144:255–263PubMed
33.
go back to reference Dennison E, Eastell R, Fall CH, Kellingray S, Wood PJ, Cooper C (1999) Determinants of bone loss in elderly men and women: a prospective population-based study. Osteoporos Int 10:384–391CrossRefPubMed Dennison E, Eastell R, Fall CH, Kellingray S, Wood PJ, Cooper C (1999) Determinants of bone loss in elderly men and women: a prospective population-based study. Osteoporos Int 10:384–391CrossRefPubMed
34.
go back to reference Kelley GA, Kelley KS, Tran ZV (2000) Exercise and bone mineral density in men: a meta-analysis. J Appl Physiol 88:1730–1736PubMed Kelley GA, Kelley KS, Tran ZV (2000) Exercise and bone mineral density in men: a meta-analysis. J Appl Physiol 88:1730–1736PubMed
35.
go back to reference Menkes A, Mazel S, Redmond RA, Koffler K, Libanati CR, Gundberg CM, Zizic TM, Hagberg JM, Pratley RE, Hurley BF (1993) Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. J Appl Physiol 74:2478–2484PubMed Menkes A, Mazel S, Redmond RA, Koffler K, Libanati CR, Gundberg CM, Zizic TM, Hagberg JM, Pratley RE, Hurley BF (1993) Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. J Appl Physiol 74:2478–2484PubMed
36.
go back to reference Ryan AS, Treuth MS, Rubin MA, Miller JP, Nicklas BJ, Landis DM, Pratley RE, Libanati CR, Gundberg CM, Hurley BF (1994) Effects of strength training on bone mineral density: hormonal and bone turnover relationships. J Appl Physiol 77:1678–1684PubMed Ryan AS, Treuth MS, Rubin MA, Miller JP, Nicklas BJ, Landis DM, Pratley RE, Libanati CR, Gundberg CM, Hurley BF (1994) Effects of strength training on bone mineral density: hormonal and bone turnover relationships. J Appl Physiol 77:1678–1684PubMed
37.
go back to reference Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling VR (2004) American College of Sports Medicine Position Stand: physical activity and bone health. Med Sci Sports Exerc 36:1985–1996CrossRefPubMed Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling VR (2004) American College of Sports Medicine Position Stand: physical activity and bone health. Med Sci Sports Exerc 36:1985–1996CrossRefPubMed
Metadata
Title
Effects of a 1-year randomized controlled trial of resistance training on lower limb bone and muscle structure and function in older men
Authors
J. Whiteford
T. R. Ackland
S. S. Dhaliwal
A. P. James
J. J. Woodhouse
R. Price
R. L. Prince
D. A. Kerr
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 9/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-009-1132-6

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