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01-04-2010 | For Debate

Filtering FRAX®

Published in: Osteoporosis International | Issue 4/2010

Excerpt

Algorithms that integrate the weight of clinical risk factors for fracture risk have been developed by the World Health Organization. This FRAX® tool (http://www.shef.ac.uk/FRAX/index.htm) computes the 10-year probability of hip fracture or a major osteoporotic fracture (clinical spine, hip, forearm, or humerus) using patient-derived clinical risk factures with or without the inclusion of femoral neck bone mineral density (BMD) [1‐4]. The FRAX® tools have been widely available for more than 18 months and are soon to be incorporated into the output of densitometers. …

University of Cincinnati Bone Health and Osteoporosis Center, Cincinnati, OH, USA

Columbia University, Toni Stabile Osteoporosis Center, New York, NY, USA

San Francisco Coordinating Center, UC San Francisco and CPMC Research Institute, San Francisco, CA, USA

San Francisco Coordinating Center, Division of General Internal Medicine, UC San Francisco, San Francisco, CA, USA

Kanis JA, Johnell O, Johansson H, McCloskey EV (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397CrossRefPubMed

World Health Organization (2007) Assessment of osteoporosis at the primary health care level. WHO, Geneva. www.who.int/chp/topics/rheumatic/en/index.html.

Kanis JA, on behalf of the World Health Organization Scientific Group (2008) Assessment of osteoporosis at the primary health-care level. Technical report. WHO Collaborating Center, University of Sheffield, UK. http://www.shef.ac.uk/FRAX/index.htm

Kanis JA, Oden A, Johnell O et al (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 18:1033–1046CrossRefPubMed

Kanis JA, Oden A, Johansson H et al (2009) FRAX® and its applications to clinical practice. Bone 44:734–743CrossRefPubMed

National Osteoporosis Foundation (2008) Clinician's guide to prevention and treatment of osteoporosis. National Osteoporosis Foundation, Washington. www.nof.org

FRAX implementation Guide at www.nof.org and www.iscd.org

Tosteson AN, Melton LJ, Dawson-Hughes B et al (2008) Cost-effective osteoporosis treatment thresholds: the United States perspective. Osteoporos Int 19:437–447CrossRefPubMed

Sinsky CA, Foreman-Hoffman V, Cram P (2007) The impact of expressions of treatment efficacy and out-of-pocket expenses on patient and physician interest in osteoporosis treatment: implications for pay-for-performance programs. J Gen Intern Med 23:164–168CrossRefPubMed

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Ettinger BE, Ettinger KM (2009) FRAX: using the new fracture risk assessment tool. Contemp Obstet Gynecol, July 2009. www.contemporaryobgyn.net.

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World Health Organisation (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Technical Report Series, No 843, WHO, Geneva.

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Cummings SR (2006) A 55 year-old woman with osteopenia. JAMA 296:2601–2610CrossRefPubMed

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Kanis JA, McCloskey EV, Johansson H, the National Osteoporosis Guideline Group et al (2008) Case finding for the management of osteoporosis with FRAX®—assessment and intervention thresholds for the UK. Osteoporos Int 19:1395–1408CrossRefPubMed

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Compston J, Cooper A, Cooper C, on behalf of the National Osteoporosis Guideline Group (NOGG) et al (2009) Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas 62:105–108CrossRefPubMed

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Kanis JA, Johnell O, Oden A et al (2006) The use of multiple sites for the diagnosis of osteoporosis. Osteoporos Int 17:527–534CrossRefPubMed

Title: Filtering FRAX®
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 4/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-1104-x

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