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Osteoporosis International

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01-08-2010 | Original Article

Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis

Authors: Z.-M. Zhang, Z.-C. Li, L.-S. Jiang, S.-D. Jiang, L.-Y. Dai

Published in: Osteoporosis International | Issue 8/2010

Abstract

Summary

An inverse relationship between osteoarthritis and osteoporosis has been debated over years. The microstructure of the femoral heads from postmenopausal osteoarthritic and osteoporotic women was evaluated with micro-CT. Significant differences were observed in microstructural parameters between them. Different microstructure might relate to the opposite bone defects in osteoarthritis and osteoporosis.

Introduction

This study was undertaken to verify the inverse relationship between osteoarthritis (OA) and osteoporosis (OP) by comparing the structural and mechanical indices.

Methods

Femoral head specimens were obtained from 17 postmenopausal women (OA, n = 8; OP, n = 9) during hip surgery. The microstructural parameters were measured with micro-CT. Mechanical test was performed after bone cube scanning.

Results

Significant difference in bone volume fraction (BV/TV) and trabecular thickness was noted between OA and OP groups. Structure model index decreased in OA, and increased in OP. The higher apparent density (AD) and lower material density (MD) were also shown in OA. Different from OP, positive correlation were noted between connectivity density and mechanical indices in OA. In OA group, BV/TV was associated with Young’s modulus and AD, while trabecular number was the only parameter that correlated with MD. However, in OP group, only BV/TV correlated with yield strength, AD, and MD.

Conclusions

We observed the difference in microstructure between postmenopausal women with OA and OP, which might relate to the opposite bone defects in OA and OP. BV/TV might play an important role in mechanical properties of the subchondral bone in either OA or OP.

Radin EL, Paul IL (1970) Does cartilage compliance reduce skeletal impact loads? The relative force-attenuating properties of articular cartilage, synovial fluid, periarticular soft tissues, and bone. Arthritis Rheum 13:139–144CrossRefPubMed

Li B, Aspden RM (1997) Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J Bone Miner Res 12:641–651CrossRefPubMed

Page WF, Hoaglund FT, Steinbach LS, Heath AC (2003) Primary osteoarthritis of the hip in monozygotic and dizygotic male twins. Twin Res 6:147–151CrossRefPubMed

Uitterlinden AG, Burger H, Huang Q, Fang Y, McGuigan FEA, Grant SFA, Hofman A, van Leeuwen JPTM, Pols HAP, Ralston SH (1998) Relation of alleles of the collagen Type Iα1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 338:1016–1021CrossRefPubMed

Yamada Y, Miyauchi A, Takagi Y, Nakauchi K, Miki N, Mizuno M, Harada A (2000) Association of a polymorphism of the transforming growth factor β-1 gene with prevalent vertebral fractures in Japanese women. Am J Med 109:244–247CrossRefPubMed

Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F, Duboeuf F, Delmas PD (2001) Bioavailable estradiol may be an important determinant of osteoporosis in men: the MINOS Study. J Clin Endocrinol Metab 86:192–199CrossRefPubMed

Riggs BL, Kholsa S, Melton LJ III (1998) A unitary model for involutional osteoporosis: estrogen deficiency causes both type 1 and type 2 osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13:763–773CrossRefPubMed

Falahati-Nini A, Riggs BL, Atkinson EJ, O’Fallon WM, Eastell R, Khosla S (2000) Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 106:1553–1556CrossRefPubMed

Antoniades L, MacGregor AJ, Andrew T, Spector TD (2003) Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology 42:791–796CrossRefPubMed

10.

Foss MVL, Byers PD (1972) Bone density, osteoarthrosis of the hip and fracture of the upper end of the femur. Ann Rheum Dis 31:259–264CrossRefPubMed

11.

Dequeker J, Franssens R, Borremans A (1971) Relationship between peripheral and axial osteoporosis and osteoarthrosis. Clin Radiol 22:74–77CrossRefPubMed

12.

Healy J, Vigorita VJ, Lane JM (1985) The coexistence and characteristics of osteoarthritis and osteoporosis. J Bone Jt Surg Am 67:586–592

13.

Dequeker J, Johnell O (1993) Osteoarthritis protects against femoral neck fracture: the MEDOS study experience. Bone 14S:51–56CrossRef

14.

El Miedany YM, Mehanna AN, El Baddini MA (2000) Altered bone mineral metabolism in patients with osteoarthritis. Jt Bone Spine 67:521–527CrossRef

15.

Lavigne P, Benderdour M, Lajeunesse D, Shi Q, Fernandes JC (2004) Expression of ICAM-1 by osteoblasts in healthy individuals and in patients suffering from osteoarthritis and osteoporosis. Bone 35:463–470CrossRefPubMed

16.

Li B, Aspden RM (1997) Material properties of bone from the femoral neck and the calcar femorale of patients with osteoporosis or osteoarthritis. Osteoporos Int 7:450–456CrossRefPubMed

17.

Li B, Aspden RM (1997) Mechanical and material properties of the subchondral bone plate from the femoral head of patients with osteoarthritis or osteoporosis. Ann Rheum Dis 56:247–254CrossRefPubMed

18.

Avci D, Bachmann GA (2004) Osteoarthritis and osteoporosis in postmenopausal women: clinical similarities and differences. Menopause 11:615–621CrossRefPubMed

19.

Chappard D, Peyrin F, Bonnassie A, Lemineur G, Brunet-Imbault B, Lespessailles E, Benhamou CL (2006) Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tomography study. Osteoarthritis Cartilage 14:215–223CrossRefPubMed

20.

Jiang LS, Zhang ZM, Jiang SD, Chen WH, Dai LY (2008) Differential bone metabolism between postmenopausal women with osteoarthritis and osteoporosis. J Bone Miner Res 23:475–483CrossRefPubMed

21.

Ding M, Odgaard A, Hvid I (2003) Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis. J Bone Jt Surg Br 85:906–912

22.

Ding M, Odgaard A, Linde F, Hvid I (2002) Age-related variations in the microstructure of human tibia cancellous bone. J Orthop Res 20:615–621CrossRefPubMed

23.

Siu WS, Qin L, Cheung WH, Leung KS (2004) A study of trabecular bones in ovariectomized goats with micro-computed tomography and peripheral quantitative computed tomography. Bone 35:21–26CrossRefPubMed

24.

Uhl M, Allmann KH, Tauer U, Laubenberger J, Adler CP, Ihling C (1998) Comparison of MR sequences in quantifying in vitro cartilage degeneration in osteoarthritis of the knee. Br J Radiol 71:291–296PubMed

25.

Dai LY (1996) The relationship between osteoarthritis and osteoporosis in the hip. J Orthop Rheumatol 9:214–216

26.

Patel V, Issever AS, Burghardt A, Laib A, Ries M, Majumdar S (2003) MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens. J Orthop Res 21:6–13CrossRefPubMed

27.

Sun SS, Ma HL, Liu CL, Huang CH, Cheng CK, Wei HW (2008) Difference in femoral head and neck material properties between osteoarthritis and osteoporosis. Clin Biomech 23:S39–S47CrossRef

28.

Hildebrand T, Laib A, Müller R, Dequeker J, Rüegsegger P (1999) Direct 3-D morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest and calcaneus. J Bone Miner Res 14:1167–1174CrossRefPubMed

29.

Gong H, Zhang M, Yeung HY, Qin L (2005) Regional variations in microstructural properties of vertebral trabeculae with aging. J Bone Miner Metab 23:174–180CrossRefPubMed

30.

Hildebrand T, Rüegsegger P (1997) Quantification of bone microarchitecture with the structure model index. Comp Meth Biomech Biomed Eng 1:15–23CrossRef

31.

Odgaard A, Gundersen HJG (1993) Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstruction. Bone 14:173–182CrossRefPubMed

32.

Day JS, Ding M, Odgaard A, Sumner DR, Hvid I, Weinans H (2000) Parallel plate model for trabecular bone exhibits volume fraction-dependent bias. Bone 27:715–720CrossRefPubMed

33.

Ding M, Hvid I (2000) Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous bone. Bone 26:291–295CrossRefPubMed

34.

Stauber M, Müller R (2006) Age-related changes in trabecular bone microstructures: global and local morphometry. Osteoporos Int 17:616–626CrossRefPubMed

35.

Ito M, Nishida A, Aoyagi K, Uetani M, Hayashi K, Kawase M (2005) Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia. Osteoporos Int 16:1042–1048CrossRefPubMed

36.

Thomsen JS, Ebbesen EN, Mosekilde L (2000) A new method of comprehensive static histomorphometry applied on human lumbar vertebral cancellous bone. Bone 27:129–138CrossRefPubMed

37.

Boyce RW, Wronski TJ, Ebert DC, Stevens ML, Paddock CL, Youngs TA, Gundersen HJ (1995) Direct stereological estimation of three-dimensional connectivity in rat vertebrae: effect of estrogen, etidronate and risedronate following ovariectomy. Bone 16:209–213CrossRefPubMed

38.

Dequeker J, Aerssens J, Luyten FP (2003) Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clin Exp Res 15:426–439PubMed

Title: Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis
Authors: Z.-M. Zhang
Z.-C. Li
L.-S. Jiang
S.-D. Jiang
L.-Y. Dai
Publication date: 01-08-2010
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 8/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-1071-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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