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Published in:

01-05-2008 | Review

Relationships between fat and bone

Author: I. R. Reid

Published in: Osteoporosis International | Issue 5/2008

Abstract

Body weight impacts both bone turnover and bone density, making it, therefore, an important risk factor for vertebral and hip fractures and ranking it alongside age in importance. The effect of body weight is probably contributed to by both fat mass and lean mass, though in postmenopausal women, fat mass has been more consistently demonstrated to be important. A number of mechanisms for the fat-bone relationship exist and include the effect of soft tissue mass on skeletal loading, the association of fat mass with the secretion of bone active hormones from the pancreatic beta cell (including insulin, amylin, and preptin), and the secretion of bone active hormones (e.g., estrogens and leptin) from the adipocyte. These factors alone probably do not fully explain the observed clinical associations, and study of the actions on bone of novel hormones related to nutrition is an important area of further research. An understanding of this aspect of bone biology may open the way for new treatments of osteoporosis. More immediately, the role of weight maintenance in the prevention of osteoporosis is an important public health message that needs to be more widely appreciated.

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Title: Relationships between fat and bone
Author: I. R. Reid
Publication date: 01-05-2008
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 5/2008
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-007-0492-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationships between fat and bone

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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