Skip to main content
Top
Published in: Osteoporosis International 9/2007

01-09-2007 | Original Article

Incidence of second hip fractures. A population-based study

Authors: E. Lönnroos, H. Kautiainen, P. Karppi, S. Hartikainen, I. Kiviranta, R. Sulkava

Published in: Osteoporosis International | Issue 9/2007

Login to get access

Abstract

Summary

We studied the incidence of second hip fractures and medication use among the patients with sequential hip fractures. This study shows that the incidence rate of second hip fractures is higher than that of the first hip fractures. Improvement in osteoporosis care and a more critical policy for prescription of psychotropic drugs are needed.

Introduction

This study had two goals: (1) to determine incidence of second hip fractures; (2) to describe changes in pharmacotherapy between first and second hip fractures, especially the use of those psychotropics which increase the risk of falling and also pharmacotherapy for osteoporosis.

Methods

The residents of Central Finland Health Care District who had sustained a hip fracture in 2002–2003 were followed up for subsequent hip fractures until 2006. Hip fracture patients were identified and clinical data were obtained by using hospital registers and medical records.

Results

Five hundred and one persons aged ≥ 60 years suffered their first hip fracture in 2002–2003. During the follow-up of 936 person-years, 34 second hip fractures occurred. The cumulative incidence of second hip fractures was 5.08% (95% CI: 3.30 to 7.78) at one year, and 8.11% (95% CI: 5.73 to 11.43) at two years after the first fracture. The second part of this study investigated 75 patients with two non-contemporaneous hip fractures. Between the first and second fractures, the number of psychotropic drug users rose from 27 (36%) to 44 (59%). At the time of second hip fracture, osteoporosis had been diagnosed in 17 (23%) patients only. Twelve (16%) patients used bisphosphonates or calcitonin, 15 (20%) used calcium and 9 (12%) vitamin D supplements.

Conclusions

There is a high incidence of second hip fractures. Secondary prevention of hip fractures needs to be improved. In addition to adequate treatment for osteoporosis, more attention should be directed toward appropriate use of psychotropic drugs.
Literature
1.
go back to reference Marks R, Allegrante JP, MacKenzie CR et al (2003) Hip fractures among the elderly: causes, consequences and control. Ageing Res Rev 2:57–93PubMedCrossRef Marks R, Allegrante JP, MacKenzie CR et al (2003) Hip fractures among the elderly: causes, consequences and control. Ageing Res Rev 2:57–93PubMedCrossRef
2.
go back to reference Kanis JA, Johnell O, De Laet C et al (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375–382PubMedCrossRef Kanis JA, Johnell O, De Laet C et al (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375–382PubMedCrossRef
4.
go back to reference Leipzig RM, Cumming RG, Tinetti ME (1999) Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 47:30–39PubMed Leipzig RM, Cumming RG, Tinetti ME (1999) Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 47:30–39PubMed
5.
go back to reference Ensrud EK, Blackwell T, Mangione CM et al (2002) Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 50:1629–1637PubMedCrossRef Ensrud EK, Blackwell T, Mangione CM et al (2002) Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 50:1629–1637PubMedCrossRef
6.
go back to reference Ziere G, Dieleman JP, Hofman A et al (2005) Polypharmacy and falls in the middle-aged and elderly population. Br J Clin Pharmacol 61:218–223CrossRef Ziere G, Dieleman JP, Hofman A et al (2005) Polypharmacy and falls in the middle-aged and elderly population. Br J Clin Pharmacol 61:218–223CrossRef
7.
go back to reference Cumming RG, Le Couteur DG (2003) Benzodiazepines and risk of hip fractures in older people. CNS Drugs 17:825–837PubMedCrossRef Cumming RG, Le Couteur DG (2003) Benzodiazepines and risk of hip fractures in older people. CNS Drugs 17:825–837PubMedCrossRef
8.
go back to reference Liu B, Anderson G, Mittmann N et al (1998) Use of selective serotonin reuptake-inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 351:1303–1307PubMedCrossRef Liu B, Anderson G, Mittmann N et al (1998) Use of selective serotonin reuptake-inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 351:1303–1307PubMedCrossRef
9.
go back to reference Wang PS, Bohn RL, Glynn RJ et al (2001) Zolpidem use and hip fractures in older people. J Am Geriatr Soc 49:1685–1690PubMedCrossRef Wang PS, Bohn RL, Glynn RJ et al (2001) Zolpidem use and hip fractures in older people. J Am Geriatr Soc 49:1685–1690PubMedCrossRef
10.
go back to reference Gass M, Dawson-Hughes B (2006) Preventing osteoporosis-related fractures: an overview. Am J Med 119:S3–S11PubMedCrossRef Gass M, Dawson-Hughes B (2006) Preventing osteoporosis-related fractures: an overview. Am J Med 119:S3–S11PubMedCrossRef
12.
go back to reference Dretakis E, Kritsikis N, Economou K et al (1981) Bilateral non-contemporary fractures of the proximal femur. Acta Orthop Scand 52:227–229PubMedCrossRef Dretakis E, Kritsikis N, Economou K et al (1981) Bilateral non-contemporary fractures of the proximal femur. Acta Orthop Scand 52:227–229PubMedCrossRef
13.
go back to reference Finsen V, Benum P (1986) The second hip fracture. An epidemiologic study. Acta Orthop Scand 57:431–433PubMedCrossRef Finsen V, Benum P (1986) The second hip fracture. An epidemiologic study. Acta Orthop Scand 57:431–433PubMedCrossRef
14.
go back to reference Chiu KY, Pun WK, Luk KDK (1992) Sequential fractures of both hips in elderly patients - a prospective study. J Trauma 32:584–587PubMed Chiu KY, Pun WK, Luk KDK (1992) Sequential fractures of both hips in elderly patients - a prospective study. J Trauma 32:584–587PubMed
15.
go back to reference Wolinsky FD, Fitzgerald JF (1994) Subsequent hip fractures among older adults. Am J Public Health 84:1316–1318PubMedCrossRef Wolinsky FD, Fitzgerald JF (1994) Subsequent hip fractures among older adults. Am J Public Health 84:1316–1318PubMedCrossRef
16.
go back to reference Dretakis KE, Dretakis EK, Papakitsou EF (1998) Possible predisposing factors for the second hip fracture. Calcif Tissue Int 62:366–369PubMedCrossRef Dretakis KE, Dretakis EK, Papakitsou EF (1998) Possible predisposing factors for the second hip fracture. Calcif Tissue Int 62:366–369PubMedCrossRef
17.
go back to reference Kaper BP, Mayer MB (2001) Incidence of bilateral proximal femoral fractures in a tertiary care center. Orthopedics 24:571–574PubMed Kaper BP, Mayer MB (2001) Incidence of bilateral proximal femoral fractures in a tertiary care center. Orthopedics 24:571–574PubMed
19.
go back to reference Chapurlat RD, Bauer DC, Nevitt M, Stone K, Cummings SR et al (2003) Incidence and risk factors for a second hip fracture in elderly women. The study of osteoporotic fractures. Osteoporos Int 14:130–136PubMed Chapurlat RD, Bauer DC, Nevitt M, Stone K, Cummings SR et al (2003) Incidence and risk factors for a second hip fracture in elderly women. The study of osteoporotic fractures. Osteoporos Int 14:130–136PubMed
20.
go back to reference Shabat S, Gepstein R, Mann G et al (2003) The second hip fracture - an analysis of 84 elderly patients. Orthop Trauma 17:613–617 Shabat S, Gepstein R, Mann G et al (2003) The second hip fracture - an analysis of 84 elderly patients. Orthop Trauma 17:613–617
21.
go back to reference Melton LJ, Ilstrup DM, Beckenbaugh RD et al (1982) Hip fracture recurrence. A population-based study. Clin Orthop Relat Res 167:131–138PubMed Melton LJ, Ilstrup DM, Beckenbaugh RD et al (1982) Hip fracture recurrence. A population-based study. Clin Orthop Relat Res 167:131–138PubMed
22.
go back to reference Schroder HM, Petersen KK, Erlandsen M (1993) Occurrence and incidence of the second hip fracture. Clin Orthop Rel Res 289:166–169 Schroder HM, Petersen KK, Erlandsen M (1993) Occurrence and incidence of the second hip fracture. Clin Orthop Rel Res 289:166–169
23.
go back to reference Yamanashi A, Yamazaki K, Kanamori M et al (2005) Assessment of risk factors for second hip fracture in Japanese elderly. Osteoporos Int 16:1239–1246PubMedCrossRef Yamanashi A, Yamazaki K, Kanamori M et al (2005) Assessment of risk factors for second hip fracture in Japanese elderly. Osteoporos Int 16:1239–1246PubMedCrossRef
24.
go back to reference Lönnroos E, Kautianen H, Karppi P et al (2006) Increased incidence of hip fractures. A population-based study in Finland. Bone 39:623–627PubMedCrossRef Lönnroos E, Kautianen H, Karppi P et al (2006) Increased incidence of hip fractures. A population-based study in Finland. Bone 39:623–627PubMedCrossRef
25.
go back to reference ICD 10 (1992) International statistical classification of diseases and related health problems, tenth revision. World Health Organization, Geneva ICD 10 (1992) International statistical classification of diseases and related health problems, tenth revision. World Health Organization, Geneva
26.
go back to reference World Health Organization (2003) Anatomical therapeutic chemical (ATC) classification index with defined daily doses (DDDs). WHO Collaborating Centre for Drug Statistics Methodology, Oslo World Health Organization (2003) Anatomical therapeutic chemical (ATC) classification index with defined daily doses (DDDs). WHO Collaborating Centre for Drug Statistics Methodology, Oslo
27.
go back to reference Stewart A, Walker LG, Porter RW et al (1999) Predicting a second hip fracture. J Clin Densitom Winter 2:363–370CrossRef Stewart A, Walker LG, Porter RW et al (1999) Predicting a second hip fracture. J Clin Densitom Winter 2:363–370CrossRef
28.
go back to reference Colon-Emeric C, Kuchibhatla M, Piper C et al (2003) The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies. Osteoporos Int 14:879–883PubMedCrossRef Colon-Emeric C, Kuchibhatla M, Piper C et al (2003) The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies. Osteoporos Int 14:879–883PubMedCrossRef
29.
go back to reference Davis CD, Ashe MC, Guy P et al (2006) Undertreatment after hip fracture: a retrospective study of osteoporosis overlooked. J Am Geriatr Soc 54:1019–1020PubMedCrossRef Davis CD, Ashe MC, Guy P et al (2006) Undertreatment after hip fracture: a retrospective study of osteoporosis overlooked. J Am Geriatr Soc 54:1019–1020PubMedCrossRef
30.
go back to reference Harrington JT, Broy SB, Derosa AM et al (2002) Hip fracture patients are not treated for osteoporosis: a call for action. Arthritis Rheum 47:651–654PubMedCrossRef Harrington JT, Broy SB, Derosa AM et al (2002) Hip fracture patients are not treated for osteoporosis: a call for action. Arthritis Rheum 47:651–654PubMedCrossRef
31.
go back to reference Follin SL, Black JN, McDermott MT (2003) Lack of diagnosis and treatment of osteoporosis in men and women after hip fracture. Pharmacotherapy 23:190–198PubMedCrossRef Follin SL, Black JN, McDermott MT (2003) Lack of diagnosis and treatment of osteoporosis in men and women after hip fracture. Pharmacotherapy 23:190–198PubMedCrossRef
32.
go back to reference Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC et al (2004) Effect of vitamin D on falls. A meta-analysis. JAMA 291:1999–2006PubMedCrossRef Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC et al (2004) Effect of vitamin D on falls. A meta-analysis. JAMA 291:1999–2006PubMedCrossRef
Metadata
Title
Incidence of second hip fractures. A population-based study
Authors
E. Lönnroos
H. Kautiainen
P. Karppi
S. Hartikainen
I. Kiviranta
R. Sulkava
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 9/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-007-0375-3

Other articles of this Issue 9/2007

Osteoporosis International 9/2007 Go to the issue