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Osteoporosis International

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01-12-2006 | Original Article

Skeletal benefits from calcium supplementation are limited in children with calcium intakes near 800 mg daily

Authors: S. Iuliano-Burns, X.-F. Wang, A. Evans, J.-P. Bonjour, E. Seeman

Published in: Osteoporosis International | Issue 12/2006

Abstract

Introduction and Hypothesis

Calcium supplementation enhances bone mass accrual during administration, with a sustained benefit observed using milk-based calcium but not calcium salts. We tested the hypothesis that calcium from milk minerals but not calcium carbonate will be sustained after supplementation was discontinued.

Methods

Ninety-nine pre-pubertal boys and girls aged 5–11 years were followed for 12 months after being randomized to receive 800 mg/day of calcium from milk minerals (MM) or calcium carbonate (CC), or a placebo (Pla) in a 10-month double blind study. Total body and regional BMC, and femoral shaft bone dimensions were measured using dual energy x-ray absorptiometry. Group differences were determined using ANCOVA.

Results

In the intention to treat analysis of the entire sample, no group differences were observed in increments in BMC or bone dimensions during or after supplementation. In those children who remained pre-pubertal, greater gains in pelvis BMC in the milk mineral group than controls were sustained (37.9 versus 29.3% respectively, p<0.02).

Conclusion

In healthy children consuming about 800 mg calcium daily, calcium supplementation with milk minerals or calcium carbonate does not appear to be produce biologically meaningful benefits to skeletal health. A benefit of calcium supplementation in pre-pubertal was evident, but inconclusive, with the biological significance of the effect of calcium supplementation at the pelvis, and the longevity of this effect to be determined.

Matkovic V, Kostial K, Simonovic I et al (1979) Bone status and fracture rates in two regions of Yugoslavia. American Journal of Clinical Nutrition 32(3):540–549PubMed

Heaney RP (2000) Calcium, dairy products and osteoporosis. J Am Coll Nutr 19(2 Suppl):83S–99SPubMed

Matkovic V, Landoll JD, Badenhop-Stevens NE et al (2004) Nutrition influences skeletal development from childhood to adulthood: a study of hip, spine, and forearm in adolescent females. J Nutr 134(3):701S–705SPubMed

Nicklas TA (2003) Calcium intake trends and health consequences from childhood through adulthood. J Am Coll Nutr 22(5):340–356PubMed

Bonjour JP, Carrie AL, Ferrari S et al (1997) Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Investigation 99(6):1287–1294PubMedCrossRef

Lee WT, Leung SS, Wang SH et al (1994) Double-blind, controlled calcium supplementation and bone mineral accretion in children accustomed to a low-calcium diet. American Journal of Clinical Nutrition 60(5):744–750PubMed

Du X, Zhu K, Trube A et al (2004) School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10–12 years in Beijing. Br J Nutr 92(1):159–168PubMedCrossRef

Lau EM, Lynn H, Chan YH et al (2004) Benefits of milk powder supplementation on bone accretion in Chinese children. Osteoporos Int 15(8):654–658PubMedCrossRef

Iuliano-Burns S, Saxon L, Naughton G et al (2003) Regional specificity of exercise and calcium during skeletal growth in girls: A randomised controlled trial. Journal of Bone Mineral Research 18(1):156–162CrossRef

10.

Lee WT, Leung SS, Leung DM et al (1996) A follow-up study on the effects of calcium-supplement withdrawal and puberty on bone acquisition of children. American Journal of Clinical Nutrition 64(1):71–77PubMed

11.

Lee WT, Leung SS, Leung DM et al (1997) Bone mineral acquisition in low calcium intake children following the withdrawal of calcium supplement. Acta Paediatrica 86(6):570–576PubMed

12.

Slemenda CW, Peacock M, Hui S et al (1997) Reduced rates of skeletal remodelling are associated with increased bone mineral density during the development of peak skeletal mass. J Bone Miner Res 12(4):676–682PubMedCrossRef

13.

Bonjour JP, Chevalley T, Ammann P et al (2001) Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up study. Lancet 358(9289):1208–1212PubMedCrossRef

14.

Chevalley T, Bonjour JP, Ferrari S et al (2005) Skeletal site selectivity in the effects of calcium supplementation on areal bone mineral density gain: a randomized, double-blind, placebo-controlled trial in prepubertal boys. J Clin Endocrinol Metab 90(6):3342–3349PubMedCrossRef

15.

Lee WT, Leung SS, Leung DM et al (1995) A randomized double-blind controlled calcium supplementation trial, and bone and height acquisition in children. British Journal of Nutrition 74(1):125–139PubMedCrossRef

16.

Tanner JM (1978) Physical growth and development. In: Fofar JO, Arnell CC (eds) Textbook of Pediatrics. Churchill Livingstone, Edinburgh, Scotland, pp 249–303

17.

Slemenda CW, Miller JZ, Hui SL et al (1991) Role of physical activity in the development of skeletal mass in children. J Bone Miner Res 6(11):1227–1233PubMedCrossRef

18.

Chemists AoOA (1990) In: Chemists AoOA (ed) Official Methods of Analysis of Official Analytical Chemists, Richmond, VA, USA, pp 1106–1107

19.

Winzenberg TM, Shaw K, Fryer J et al (2006) Calcium supplementation for improving bone mineral density in children. Cochrane Database Syst Rev (2):CD005119PubMed

20.

Peacock M, Liu G, Carey M et al (2000) Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab 85(9):3011–3019PubMedCrossRef

21.

Johnston CC Jr, Miller JZ, Slemenda CW et al (1992) Calcium supplementation and increases in bone mineral density in children. N Engl J Med 327(2):82–87PubMedCrossRef

22.

Abrams SA, Copeland KC, Gunn SK et al (2000) Calcium absorption, bone mass accumulation, and kinetics increase during early pubertal development in girls. J Clin Endocrinol Metab 85(5):1805–1809PubMedCrossRef

23.

Takada Y, Aoe S, Kumegawa M (1996) Whey protein stimulated the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun 223(2):445–449PubMedCrossRef

24.

Aoe S, Toba Y, Yamamura J et al (2001) Controlled trial of the effects of milk basic protein (MBP) supplementation on bone metabolism in healthy adult women. Biosci Biotechnol Biochem 65(4):913–918PubMedCrossRef

25.

Toba Y, Takada Y, Matsuoka Y et al (2001) Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men. Biosci Biotechnol Biochem 65(6):1353–1357PubMedCrossRef

26.

Dibba B, Prentice A, Ceesay M et al (2002) Bone mineral contents and plasma osteocalcin concentrations of Gambian children 12 and 24 mo after the withdrawal of a calcium supplement. Am J Clin Nutr 76(3):681–686PubMed

Title: Skeletal benefits from calcium supplementation are limited in children with calcium intakes near 800 mg daily
Authors: S. Iuliano-Burns
X.-F. Wang
A. Evans
J.-P. Bonjour
E. Seeman
Publication date: 01-12-2006
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2006
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0196-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Skeletal benefits from calcium supplementation are limited in children with calcium intakes near 800 mg daily

Abstract

Introduction and Hypothesis

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and Hypothesis

Methods

Results

Conclusion

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