Top

Osteoporosis International

Published in:

01-03-2006 | Original Article

Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia

Authors: S. Bakhtiyarova, O. Lesnyak, N. Kyznesova, M. A. Blankenstein, P. Lips

Published in: Osteoporosis International | Issue 3/2006

Abstract

Purpose

Vitamin D deficiency leads to secondary hyperparathyroidism and osteomalacia, and both conditions are associated with fractures, the most severe being hip fracture. The serum 25-hydroxyvitamin D level depends on latitude and season. Yekaterinburg is situated at a high latitude and the duration of winter is about 5 months.

Methods

In this study, the serum 25(OH)D and PTH concentrations, and the prevalence of hypovitaminosis D in elderly people, inhabitants of Yekaterinburg, were investigated. The study was performed on 63 people with hip fracture (mean age, 68.8 years) and 97 independently living elderly people (mean age, 70.2 years).

Results

Serum 25(OH)D (mean±SD) in the hip fracture group was 22.4±11.4 nmol/L, significantly lower than in control group, which was 28.1±10.1 nmol/L. The percentage of patients with severe hypovitaminosis D (<25 nmol/L) in the hip fracture group was 65%, compared to 47% in the control group (p<0.05). The prevalence of hypovitaminosis D among hip fracture patients, as well as among independently living elderly people in Yekaterinburg, was high.

Conclusion

Supplementation of vitamin D in elderly people with and without fracture might prevent secondary hyperparathyroidism, osteomalacia and fractures.

Lips P (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477–501CrossRefPubMed

Thomas MK, Lloyd-Jones DM, Thadhani RI, Snaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS (1998) Hypovitaminosis D in medical inpatients. N Engl J Med 338:777–783PubMedCrossRef

McKenna MJ, Freaney R, Meade A, Muldowney FP (1985) Hypovitaminosis D and elevated serum alkaline phosphatase in elderly Irish people. Am J Clin Nutr 41:101–109PubMed

Parfitt AM (1998) Osteomalacia and related disorders. In: Avioli LV, Krane SM (eds) Metabolic bone disease, 3rd edn. Academic Press, San Diego, California, pp 327–386

Nasonov E (1998) Vitamin D and calcium deficiency: new facts and hypothesis (in Russian). Osteoporosis Osteopat 3:42–47

Chapuy MC, Chapuy P, Thomas JL, Hazard MC, Meunier PJ (1996) Biochemical effects of calcium and vitamin D supplementation in elderly, institutionalized, vitamin D-deficient patients. Rev Rhum 63:135–140

Lips P, van Ginkel FC, Jongen MJM, Rubertus F, van der Vijgh WJF, Netelenbos JC (1987) Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr 46:1005–1010PubMed

Lips P, Duong T, Oleksik A., Black D, Cummings S, Cox D, Nickelsen T (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab 86:1212–1221PubMedCrossRef

Ooms ME, Roos JC, Bezemer PD, van der Vijgh WJF, Bouter LM, Lips P (1995) Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial. J Clin Endocrinol Metab 80:1052–1058PubMedCrossRef

10.

Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ (1992) Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 327:1637–1642PubMedCrossRef

11.

Carter GD, Carter CR, Gunter E, Jones J, Jones G, Makin HLJ, Safi S (2004) Measurement of vitamin D metabolites: an international perspective on methodology and clinical interpretation. J Steroid Biochem Mol Biol 89–90:467–471CrossRefPubMed

12.

Sato Y, Kaji M, Higuchi F, Yanagida I, Oishi K, Oizumi K (2001) Changes in bone and calcium metabolism following hip fracture in elderly patients. Osteoporos Int 12:445–449PubMedCrossRef

13.

Boonen S, Vanderschueren D, Cheng XG, Verbeke G, Dequeker J, Geusens P, Broos P, Bouillon R (1997) Age-related (type II) femoral neck osteoporosis in men: biochemical evidence for both hypovitaminosis D and androgen deficiency-induced bone resorption. J Bone Miner Res 12:2119–2126PubMedCrossRef

14.

LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J (1999) Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 281:1505–1511PubMedCrossRef

15.

Delvin EE, Imbach A, Copti M (1988) Vitamin D nutritional status and related biochemical indices in an autonomous elderly population. Am J Clin Nutr 48:373–378PubMed

16.

Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 67:373–378PubMedCrossRef

17.

Lips P (1996) Vitamin D deficiency and osteoporosis: the role of vitamin D deficiency and treatment with vitamin D and analogues in the prevention of osteoporosis-related fractures. Eur J Clin Investig 26:436–442CrossRef

18.

Lips P, Wiersinga A, van Ginkel FC, Jongen MJM, Netelenbos JS, Hackeng WHL, Delmas PD, van der Vijgh WJF (1988) The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab 67:644–650PubMed

19.

Guillemant J, Taupin P, Le HT, Taright N, Allemandou A, Peters G, Guillemant S (1999) Vitamin D status during puberty in French healthy male adolescents. Osteoporosis Int 10:222–225CrossRef

20.

Dawson-Hughes B, Dallal GE, Krall EA, Harris S, Sokoll LJ, Falconer G (1991) Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 115:505–512PubMed

21.

Lips P, Graafmans WC, Ooms ME, Bezemer PD, Bouter LM (1996). Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med 124:400–406PubMed

22.

Dawson-Hughes B, Harris SS, Krall EA, Dallal GE (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age and older. N Engl J Med 337:670–676CrossRefPubMed

23.

Trivedi DP, Doll R, Khaw KT (2003) Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326:469–472CrossRefPubMed

24.

Larsen ER, Mosekilde L, Foldspang A (2004) Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res 19:370–378PubMedCrossRef

25.

Holick MF (2003) Vitamin D: a millennium perspective. J Cell Biochem 88:296–307CrossRefPubMed

26.

Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B (2004) Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116:634–639CrossRefPubMed

27.

Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, Dawson-Hughes B (2004) Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or = 60 y. Am J Clin Nutr 80:752–758PubMed

28.

Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R (2005) Estimates of optimal vitamin D status. Osteoporosis Int 16:713–716CrossRef

Title: Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia
Authors: S. Bakhtiyarova
O. Lesnyak
N. Kyznesova
M. A. Blankenstein
P. Lips
Publication date: 01-03-2006
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 3/2006
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-005-0006-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 3/2006

A simple method for determining the probability a new vertebral fracture is present in postmenopausal women with osteoporosis

Review: developmental origins of osteoporotic fracture

Differences in bone size and bone mass between black and white 10-year-old South African children

Letter

Racial variations in antiresorptive medication use: results from the 2000 Medical Expenditure Panel Survey (MEPS)

Osteoporosis intervention in ambulatory patients with previous hip fracture: a multicentric, nationwide Italian survey