Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Osteoporosis International
Published in: Osteoporosis International 3/2004

01-03-2004 | Original Article

Relationship between body composition and bone mineral density in healthy young and premenopausal Chinese women

Authors: Jian-Min Liu, Hong-Yan Zhao, Guang Ning, Yong-Ju Zhao, Lian-Zhen Zhang, Li-Hao Sun, Man-Yin Xu, Jia-Lun Chen

Published in: Osteoporosis International | Issue 3/2004

Login to get access

Abstract

This study investigated the relative contribution of fat mass and lean mass to bone mineral density (BMD) in young and premenopausal healthy Chinese women. The study was performed in 282 young and premenopausal healthy women with regular menstrual cycles. The BMD at lumbar spine (L2–L4), total hip and total body, together with fat mass and lean mass were assessed by dual-energy X-ray absorptiometry (DXA); body height, weight, waist and hip circumference were also measured, and body mass index (BMI) and waist-hip ratio were calculated. Fat mass was a major determinant for BMI, BMI and lean mass were positively related to L2–L4, total hip and total body bone density (P<0.001 for all), lean mass was the only independent factor contributing to BMD at L2–L4 (standardized coefficient β=0.282, P<0.001), total hip (β=0.336, P<0.001) and total body (β=0.361, P<0.001) in multiple stepwise regression analysis. The correlation between BMI and BMD was improved after adjustment for fat mass, while decreased or even lost when lean mass was adjusted. These data suggested that in the Chinese population, lean mass is an important factor determining BMD in young and premenopausal women.
Literature
1.
Steigre P, Cummings SR, Black DM et al. (1992) Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 6:625–632
2.
Ravn P, Cizza G, Bjarnason NH et al. (1999) Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early postmenopausal intervention Cohort (ERIC) study group. J Bone Miner Res 14:1622–1627PubMed
3.
McGuigan FE, Murray L, Gallagher A et al. (2002) Genetic and environmental determinants of peak bone mass in young men and women. J Bone Miner Res 17:1273–1279PubMed
4.
Felson DT, Zhang Y, Hannan MT et al. (1993) Effects of weight and body mass index on bone mineral density in men and women: Framingham Study. J Bone Miner Res 8:567–573PubMed
5.
Hawker GA, Jamal SA, Ridout R et al. (2002) A clincial prediction rule to identify premenopausal women with low bone mass. Osteoporos Int 13:400–406CrossRef
6.
Munaisinghe RL, Rotea V, Edelson GW (2002) Association among age, height, weight, and body mass index with discordant regional bone mineral density. J Clin Densitom 5:369–373CrossRefPubMed
7.
Sirola J, Kroger H, Honkanen R et al. (2003) Risk factors associated with peri- and postmenopausal bone loss:does HRT prevent weight loss-related bone loss. Osteoporos Int 14:27–33CrossRefPubMed
8.
Lindsay RB, Hanson RL, Roumain J et al. (2001) Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy X-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab 86:4061–4067PubMed
9.
Daniels SR, Khoury PR, Morrison JA (1997) The utility of body mass index as a measure of body fatness in children and adolescents: differences by race and gender. Pediatrics 99:507–526
10.
Reid IR, Plank LD, and Evans MC (1992) Fat mass is an important determinant of whole body bone density in premenopausal women but not in men. J Clin Endocrinol Metab 75:779–782
11.
Bedogni G, Mussi C, Malavolti M et al. (2002) Relationship between body composition and bone mineral content in young and elderly women. Ann Hum Biol 29:559–565CrossRefPubMed
12.
Langendonck LV, Claessens AL, Lefevre J et al. (2002) Association between bone mineral density, body structure, and body composition in middle-aged men. Am J Human Biol 14:735–742CrossRefPubMed
13.
Kopelman PG (2000) Obesity as a medical problem. Nature 404:635–643PubMed
14.
Ellis KJ (2000) Human body composition: in vivo methods. Physiol Rev 80:649–680PubMed
15.
Wong WW, Hergenroeder AC, Stuff JE et al. (2002) Evaluating body fat in girls and female adolescents: advantages and disadvantages of dual-energy X-ray absorptiometry. Am J Clin Nutr 76:384–389PubMed
16.
Ijuin M, Douchi T, Matsuo T et al. (2002) Difference in the effects of body composition on bone mineral density between pre- and postmenopausal women. Maturitas 43:239–244CrossRefPubMed
17.
Wu XP, Liao EY, Huang G et al. (2003) A comparison study of the reference curves of bone mineral density at different skeletal sites in Native Chinese, Japanese, and American Caucasian women. Calcif Tissue Int 73:122–132PubMed
18.
Lin YC, Lybe BM, Weaver CM et al. (2003) Peak spine and femoral neck bone mass in young women. Bone 32:546–553CrossRefPubMed
19.
Winters KM, Snow CM (2000) Body composition predicts bone mineral density and balance in premenopausal women. J Womens Health Gend Based Med 9:865–872CrossRefPubMed
20.
Ferretti JL, Capozza RF, Cointry GR et al. (1998) Gender-related differences in the relationship between densitometric values of whole-body mineral content and lean body mass in humans between 2 and 87 years of age. Bone 22:683–690CrossRefPubMed
21.
Pietrobelli A, Faith MS, Wang J et al. (2002) Association of lean tissue and fat mass with bone mineral content in children and adolescents. Obes Res 10:56–60PubMed
22.
Ilich-Ernst J, Brownbill RA, Ludemann MA et al. (2002) Critical factors for bone health in women across the age span: how important is muscle mass? Medscape Womens Health 7:2
23.
Valdimarsson O, Kristinsson JO, Stefansson SO et al .(1999) Lean mass and physical activity as predictors of bone mineral density in 16–20-year old women. J Int Med 245:489–496CrossRef
24.
Young D, Hopper JL, Cacinnis RJ et al. (2001) Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8- to 26-year-old female twins. Osteoporos Int 12:506–515CrossRefPubMed
25.
Aloia JF, Vaswani A, Ma RM et al. (1995) To what extent is bone mass determined by fat-free or fat mass? Am J Clin Nutr 61:1110–1114PubMed
26.
Fox MX, Magaziner J, Hawkes WG et al. (2000) Loss of bone density and lean body mass after hip fracture. Osteoporos Int 11:31–35CrossRefPubMed
27.
Kirchengast S, Peterson B, Hauser G et al. (2001) Body composition characteristics are associated with the bone density of the proximal femur end in middle- and old-aged women and men. Maturitas 39:133–145CrossRefPubMed
28.
Weiler HA, Janzen L, Green K et al. (2000) Percent body fat and bone mass in healthy Canadian females 10–19 years of age. Bone 27:203–207CrossRefPubMed
29.
Jensen LB, Vestergaard P, Hermann AP et al. (2003) Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: a randomized controlled 5-year clinical trial of the Danish Osteoporosis Prevention Study. J Bone Miner Res 18:333–342PubMed
30.
Nguyen TV, Howard GM, Kelly PJ et al. (1998) Bone mass, lean mass, and fat mass: same genes or same environments? Am J Epidemiol 147:3–16PubMed
31.
Hopper JL, GreenRM, Nowson CA et al. (1998) Genetic, common environment, and individual specific components of variance for bone mineral density in 10- to 26-year-old females: a twin study. Am J Epidemiol 147:17–29PubMed
32.
Finkelstein JS, Lee ML, Sowers M et al. (2002) Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 87:3057–3067
33.
McKay HA, Petit MA, Khan KM et al. (2002) Lifestyle determinants of bone mineral: a comparison between prepubertal Asian- and Caucasian-Canadian boys and girls. Calcif Tissue Int 66:320–324CrossRef
34.
Douchi T, Yamanoto S, Yoshimitsu N et al. (2002) Relative contribution of aging and menopause to changes in lean and fat mass in segmental regions. Maturitas 42:301–306CrossRefPubMed
35.
36.
Courteix D, Lespessailles E, Loiseau-Peres S et al. (1998) Lean tissue mass is a better predictor of bone mineral content and density than body weight in prepubertal girls. Rev Rheum Engl Ed 65:328–336
Metadata
Title
Relationship between body composition and bone mineral density in healthy young and premenopausal Chinese women
Authors
Jian-Min Liu
Hong-Yan Zhao
Guang Ning
Yong-Ju Zhao
Lian-Zhen Zhang
Li-Hao Sun
Man-Yin Xu
Jia-Lun Chen
Publication date
01-03-2004
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 3/2004
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1536-7

Other articles of this Issue 3/2004

Osteoporosis International 3/2004 Go to the issue

Original Article

Fracture risk following an osteoporotic fracture

Original Article

Broadband ultrasound attenuation (BUA) of the heel bone and its correlates in men and women in the EPIC-Norfolk cohort: a cross-sectional population-based study

Original Article

Calcaneal ultrasound predicts early postmenopausal fractures as well as axial BMD. A prospective study of 422 women

Original Article

The osteoporotic pain experience

Original Article

Amylin fasting plasma levels are decreased in patients with osteoporosis

Original Article

Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE study