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Osteoporosis International
Published in: Osteoporosis International 9/2003

01-09-2003 | Review

Searching for osteoporosis genes in the post-genome era: progress and challenges

Authors: Qing-Yang Huang, Robert R. Recker, Hong-Wen Deng

Published in: Osteoporosis International | Issue 9/2003

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Abstract

Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD), deterioration of bone microarchitecture and increased fracture risk. It is a complex disease that has high social and economic costs. Osteoporosis and its associated phenotypes are under the strong genetic control. Identification and characterization of specific loci or genes involved in determining osteoporosis and its associated phenotypes will contribute to a greater understanding of the pathogenesis of osteoporosis, and ultimately might lead to the development of better diagnosis, prevention and treatment strategies. Efforts to identify osteoporosis genes have focused on three approaches: animal models, candidate gene approach, and genome-wide scans. In this article, we review the current status for mapping and identification of genes for osteoporosis, with a focus on some promising regions and future prospects.
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Metadata
Title
Searching for osteoporosis genes in the post-genome era: progress and challenges
Authors
Qing-Yang Huang
Robert R. Recker
Hong-Wen Deng
Publication date
01-09-2003
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 9/2003
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1445-9

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