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International Urogynecology Journal

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01-02-2011 | Original Article

Evaluation of the biocompatibility and mechanical properties of xenogeneic (porcine) extracellular matrix (ECM) scaffold for pelvic reconstruction

Authors: Lubin Liu, Deng Li, Yanzhou Wang, Huicheng Xu, Liangpeng Ge, Zhiqing Liang

Published in: International Urogynecology Journal | Issue 2/2011

Abstract

Introduction and hypothesis

Xenogeneic (porcine) extracellular matrix (ECM) scaffolds have been suggested as ideal biomaterials for regeneration medicine; however, ECM prepared from different tissue sources has shown distinctive biological properties. Therefore, a comprehensive understanding of biological characteristics of different tissue-derived ECM is essential in the design of scaffolds for pelvic reconstruction.

Methods

We compared the biological properties of ECM derived from different tissue sources of Bama miniature pigs as a pelvic biological patch in terms of histological structure, water absorption ability, biodegradation ability, mechanical properties, antimicrobial activity, and biocompatibility in vitro.

Results

Different ECM scaffolds have distinct structural differences, and all have good biocompatibility, and UBM exhibited better water uptake ability (above 500%), anti-biodegradation ability, mechanical properties, antimicrobial activity, and stem cell attachment properties than other tissue-derived ECM.

Conclusions

Porcine UBM might serve as an ideal pelvic biological patch.

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Title: Evaluation of the biocompatibility and mechanical properties of xenogeneic (porcine) extracellular matrix (ECM) scaffold for pelvic reconstruction
Authors: Lubin Liu
Deng Li
Yanzhou Wang
Huicheng Xu
Liangpeng Ge
Zhiqing Liang
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 2/2011
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1288-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evaluation of the biocompatibility and mechanical properties of xenogeneic (porcine) extracellular matrix (ECM) scaffold for pelvic reconstruction

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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