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International Urogynecology Journal

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Open Access 01-12-2010 | Original Article

An open multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and mixed urinary incontinence

Authors: Gunnar Lose, Helle Christina Sørensen, Susanne M. Axelsen, Christian Falconer, Kurt Lobodasch, Tosson Safwat

Published in: International Urogynecology Journal | Issue 12/2010

Abstract

Introduction

Polyacrylamide hydrogel (PAHG, Bulkamid®) is a promising urethral bulking agent. This multicenter study was carried out to evaluate safety and efficacy of Bulkamid® for female stress and mixed urinary incontinence.

Methods

Submucosal injection of Bulkamid® was performed in 135 women with urinary incontinence (stress, 67; mixed, 68) followed for 12 months. Forty-seven had a reinjection (35%).

Results

At 12 months, the subjective response rate was 66%. Incontinence episodes/24 h and urine leakage g/24 h decreased significantly (from 3.0 to 0.7 and 29 g to 4 g, respectively). Additionally, the median International Consultation on Incontinence Questionnaire score was reduced to approximately 50%, and the overall quality of life visual analogue scale score was decreased significantly (from 72 to 20). Efficacy was very similar between patients with stress and mixed incontinence. Thirty treatment-related adverse events were registered. The most frequent was urinary tract infection (n = 10). No polyacrylamide hydrogel-specific adverse events were seen.

Conclusions

Bulkamid® is an effective and safe bulking agent in women with stress or mixed incontinence.

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Title: An open multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and mixed urinary incontinence
Authors: Gunnar Lose
Helle Christina Sørensen
Susanne M. Axelsen
Christian Falconer
Kurt Lobodasch
Tosson Safwat
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 12/2010
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1214-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

An open multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and mixed urinary incontinence

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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