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Knee Surgery, Sports Traumatology, Arthroscopy

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01-12-2017 | Knee

Microbial resistance related to antibiotic-loaded bone cement: a historical review

Authors: Lucy C. Walker, Paul Baker, Richard Holleyman, David Deehan

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 12/2017

Abstract

Purpose

The use of antibiotic-loaded bone cement (ALBC) has a range of indications for use in orthopaedics. It has the advantage of delivering high loads of antibiotics to a targeted site, thereby avoiding the side effects associated with systemic administration. However, there is concern that the use of ALBC may precipitate the development of antibiotic-resistant bacteria.

Methods

This review focuses on (1) the published research using both animal and human models examining the association between ALBC and the induction of microbial resistance (2) the mechanisms by which antimicrobial resistance develop (3) the research pertaining to specific classes of antibiotics commonly used in orthopaedic practice (4) the recent developments in calcium sulphate beads, nanoparticles and chitosan, as alternative antimicrobial treatments for periprosthetic joint infections.

Conclusion

The literature for and against a link between ALBC and the development of microbiological resistance is reviewed and presented. It is concluded that further research is needed to develop a defined set of indications for the use of ALBC in the management of periprosthetic joint infection. In addition, further research into alternative antimicrobial therapies in this area should be encouraged.

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Title: Microbial resistance related to antibiotic-loaded bone cement: a historical review
Authors: Lucy C. Walker
Paul Baker
Richard Holleyman
David Deehan
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 12/2017
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-016-4309-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Microbial resistance related to antibiotic-loaded bone cement: a historical review

Abstract

Purpose

Methods

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Conclusion

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