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Knee Surgery, Sports Traumatology, Arthroscopy
Published in: Knee Surgery, Sports Traumatology, Arthroscopy 3/2012

Open Access 01-03-2012 | Knee

Biomechanical considerations in the pathogenesis of osteoarthritis of the knee

Authors: Andras Heijink, Andreas H. Gomoll, Henning Madry, Matej Drobnič, Giuseppe Filardo, João Espregueira-Mendes, C. Niek Van Dijk

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 3/2012

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Abstract

Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis of knee osteoarthritis in the young patient is predominantly related to an unfavorable biomechanical environment at the joint. This results in mechanical demand that exceeds the ability of a joint to repair and maintain itself, predisposing the articular cartilage to premature degeneration. This review examines the available basic science, preclinical and clinical evidence regarding several such unfavorable biomechanical conditions about the knee: malalignment, loss of meniscal tissue, cartilage defects and joint instability or laxity.
Level of evidence IV.
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Metadata
Title
Biomechanical considerations in the pathogenesis of osteoarthritis of the knee
Authors
Andras Heijink
Andreas H. Gomoll
Henning Madry
Matej Drobnič
Giuseppe Filardo
João Espregueira-Mendes
C. Niek Van Dijk
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 3/2012
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-011-1818-0

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