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Knee Surgery, Sports Traumatology, Arthroscopy

Published in:

01-06-2012 | Knee

Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee

Authors: A. A. M. Dhollander, P. C. M. Verdonk, S. Lambrecht, R. Verdonk, D. Elewaut, G. Verbruggen, K. F. Almqvist

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 6/2012

Abstract

Purpose

To evaluate short-term clinical and MRI outcome of the second generation characterized chondrocyte implantation (CCI) for the treatment of cartilage defects in the knee.

Methods

Thirty-two patients aged 15–51 years with single International Cartilage Repair Society (ICRS) grade III/IV symptomatic cartilage defects of different locations in the knee were treated with CCI using a synthetic collagen I/III membrane to cover the defect. Clinical outcome was measured over 36 months by the Knee injury and Osteoarthritis Outcome Score (KOOS) and Visual Analogue Scale (VAS) for pain. Serial magnetic resonance imaging (MRI) scans of 22 patients were scored using the original and modified Magnetic resonance Observation of Cartilage Repair Tissue (MOCART) system.

Results

The patients included in this study showed a significant gradual clinical improvement after CCI. The MRI findings of this pilot study were considered to be promising. No signs of deterioration were observed. A complete or hypertrophic filling was observed in 76.5% of the cases at 24 months of follow-up. No preventive effect of an avital membrane on the occurrence of hypertrophic repair tissue was observed on MRI. Three failures were observed among the 32 patients until now (9.4%).

Conclusions

This investigation provided useful information on the efficacy of this treatment. The short-term clinical and MRI outcome are promising. Large-scale and long-term trials are mandatory to confirm the results and the reliability of this procedure.

Level of evidence

IV.

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Title: Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee
Authors: A. A. M. Dhollander
P. C. M. Verdonk
S. Lambrecht
R. Verdonk
D. Elewaut
G. Verbruggen
K. F. Almqvist
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 6/2012
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-011-1759-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee

Abstract

Purpose

Methods

Results

Conclusions

Level of evidence

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Level of evidence

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