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Knee Surgery, Sports Traumatology, Arthroscopy

Published in:

01-02-2012 | Experimental Study

Fibrin glue does not improve the fixation of press-fitted cell-free collagen gel plugs in an ex vivo cartilage repair model

Authors: Turgay Efe, Alexander Füglein, Thomas J. Heyse, Thomas Stein, Nina Timmesfeld, Susanne Fuchs-Winkelmann, Jan Schmitt, Jürgen R. J. Paletta, Markus D. Schofer

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 2/2012

Abstract

Purpose

Adequate graft fixation over a certain time period is necessary for successful cartilage repair and permanent integration of the graft into the surrounding tissue. The aim of the present study was to test the primary stability of a new cell-free collagen gel plug (CaReS^®-1S) with two different graft fixation techniques over a simulated early postoperative period.

Methods

Isolated chondral lesions (11 mm diameter by 6 mm deep) down to the subchondral bone plate were created on the medial femoral condyle in 40 porcine knee specimens. The collagen scaffolds were fixed in 20 knees each by press-fit only or by press-fit + fibrin glue. Each knee was then put through 2,000 cycles in an ex vivo continuous passive motion model. Before and after the 2,000 motions, standardized digital pictures of the grafts were taken. The area of worn surface as a percentage of the total collagen plug surface was evaluated using image analysis software.

Results

No total delamination of the scaffolds to leave an empty defect site was recorded in any of the knees. The two fixation techniques showed no significant difference in worn surface area after 2,000 cycles (P = n.s.).

Conclusions

This study reveals that both the press-fit only and the press-fit + fibrin glue technique provide similar, adequate, stability of a type I collagen plug in the described porcine model. In the clinical setting, this fact may be particularly important for implantation of arthroscopic grafts.

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Title: Fibrin glue does not improve the fixation of press-fitted cell-free collagen gel plugs in an ex vivo cartilage repair model
Authors: Turgay Efe
Alexander Füglein
Thomas J. Heyse
Thomas Stein
Nina Timmesfeld
Susanne Fuchs-Winkelmann
Jan Schmitt
Jürgen R. J. Paletta
Markus D. Schofer
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 2/2012
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-011-1571-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Fibrin glue does not improve the fixation of press-fitted cell-free collagen gel plugs in an ex vivo cartilage repair model

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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