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Knee Surgery, Sports Traumatology, Arthroscopy

Published in:

01-10-2008 | Knee

Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model

Authors: S. Løken, R. B. Jakobsen, A. Årøen, S. Heir, A. Shahdadfar, J. E. Brinchmann, L. Engebretsen, F. P. Reinholt

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 10/2008

Abstract

The purpose of this study was to evaluate the efficiency of using mesenchymal stem cells (MSC) in a hyaluronan scaffold for repair of an osteochondral defect in rabbit knee. Bone marrow was harvested from the posterior iliac crest in 11 New Zealand White rabbits. MSC were isolated and cultured in autologous serum for 28 days and transferred to a hyaluronan scaffold 24 h prior to implantation. A 4 mm diameter and 1.5 mm deep defect was created in the medial femoral condyle of both knees and the scaffold with MSC was implanted in one knee while an empty scaffold was implanted in the contra-lateral knee. After 24 weeks the rabbits were killed and histological sections were subjected to semiquantitative and quantitative evaluation by observers blinded regarding treatment modality. High degree of filling was obtained, but there was no statistically significant difference between the two treatments. However, there was a tendency for a better quality of repair in the MSC treated knees. No hypertrophy was observed by either method. MSC in a hyaluronan scaffold may be a promising treatment approach, but further studies are needed to determine the best combination of scaffold and cells.

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Title: Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model
Authors: S. Løken
R. B. Jakobsen
A. Årøen
S. Heir
A. Shahdadfar
J. E. Brinchmann
L. Engebretsen
F. P. Reinholt
Publication date: 01-10-2008
Publisher: Springer-Verlag
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 10/2008
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-008-0566-2

2024 ASCO Annual Meeting

Springer Medicine

Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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