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Published in: Intensive Care Medicine 4/2024

18-03-2024 | Editorial

Decolonization strategies against multidrug resistant organisms in the ICU

Authors: Pedro Póvoa, Paula Ramirez, Stijn Blot

Published in: Intensive Care Medicine | Issue 4/2024

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Excerpt

Multiple-drug resistant organisms (MDRO) are a consequence of antibiotic pressure, selection, and infection control failure. Regional variation in MDRO rates is evident [1]. …
Literature
1.
go back to reference Blot S, Ruppe E, Harbarth S et al (2022) Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies. Intensive Crit Care Nurs 70:103227CrossRefPubMedPubMedCentral Blot S, Ruppe E, Harbarth S et al (2022) Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies. Intensive Crit Care Nurs 70:103227CrossRefPubMedPubMedCentral
3.
go back to reference Bassetti M, Righi E, Vena A et al (2018) Risk stratification and treatment of ICU-acquired pneumonia caused by multidrug- resistant/extensively drug-resistant/pandrug-resistant bacteria. Curr Opin Crit Care 24:385–393CrossRefPubMed Bassetti M, Righi E, Vena A et al (2018) Risk stratification and treatment of ICU-acquired pneumonia caused by multidrug- resistant/extensively drug-resistant/pandrug-resistant bacteria. Curr Opin Crit Care 24:385–393CrossRefPubMed
4.
go back to reference Macesic N, Gomez-Simmonds A, Sullivan SB et al (2018) Genomic surveillance reveals diversity of multidrug-resistant organism colonization and infection: a prospective cohort study in liver transplant recipients. Clin Infect Dis 67:905–912CrossRefPubMedPubMedCentral Macesic N, Gomez-Simmonds A, Sullivan SB et al (2018) Genomic surveillance reveals diversity of multidrug-resistant organism colonization and infection: a prospective cohort study in liver transplant recipients. Clin Infect Dis 67:905–912CrossRefPubMedPubMedCentral
5.
go back to reference Ontario H (2022) Pre-surgical nasal decolonization of staphylococcus aureus: a health technology assessment. Ont Health Technol Assess Ser 22:1–165 Ontario H (2022) Pre-surgical nasal decolonization of staphylococcus aureus: a health technology assessment. Ont Health Technol Assess Ser 22:1–165
7.
go back to reference Huang SS, Septimus EJ, Kleinman K et al (2023) Nasal iodophor antiseptic vs nasal mupirocin antibiotic in the setting of chlorhexidine bathing to prevent infections in adult ICUs: a randomized clinical trial. JAMA 330:1337–1347CrossRefPubMedPubMedCentral Huang SS, Septimus EJ, Kleinman K et al (2023) Nasal iodophor antiseptic vs nasal mupirocin antibiotic in the setting of chlorhexidine bathing to prevent infections in adult ICUs: a randomized clinical trial. JAMA 330:1337–1347CrossRefPubMedPubMedCentral
8.
go back to reference Wittekamp BH, Plantinga NL, Cooper BS et al (2018) Decontamination strategies and bloodstream infections with antibiotic-resistant microorganisms in ventilated patients: a randomized clinical trial. JAMA 320:2087–2098CrossRefPubMedPubMedCentral Wittekamp BH, Plantinga NL, Cooper BS et al (2018) Decontamination strategies and bloodstream infections with antibiotic-resistant microorganisms in ventilated patients: a randomized clinical trial. JAMA 320:2087–2098CrossRefPubMedPubMedCentral
9.
go back to reference Blot S (2021) Antiseptic mouthwash, the nitrate-nitrite-nitric oxide pathway, and hospital mortality: a hypothesis generating review. Intensive Care Med 47:28–38CrossRefPubMed Blot S (2021) Antiseptic mouthwash, the nitrate-nitrite-nitric oxide pathway, and hospital mortality: a hypothesis generating review. Intensive Care Med 47:28–38CrossRefPubMed
10.
go back to reference Dale CM, Rose L, Carbone S et al (2021) Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial. Intensive Care Med 47:1295–1302CrossRefPubMedPubMedCentral Dale CM, Rose L, Carbone S et al (2021) Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial. Intensive Care Med 47:1295–1302CrossRefPubMedPubMedCentral
12.
go back to reference Denkel LA, Schwab F, Clausmeyer J et al (2022) Effect of antiseptic bathing with chlorhexidine or octenidine on central line-associated bloodstream infections in intensive care patients: a cluster-randomized controlled trial. Clin Microbiol Infect 28:825–831CrossRefPubMed Denkel LA, Schwab F, Clausmeyer J et al (2022) Effect of antiseptic bathing with chlorhexidine or octenidine on central line-associated bloodstream infections in intensive care patients: a cluster-randomized controlled trial. Clin Microbiol Infect 28:825–831CrossRefPubMed
13.
go back to reference Denkel LA, Schwab F, Clausmeyer J et al (2023) Central-line associated bloodstream infections in intensive care units before and after implementation of daily antiseptic bathing with chlorhexidine or octenidine: a post-hoc analysis of a cluster-randomised controlled trial. Antimicrob Resist Infect Control 12:55CrossRefPubMedPubMedCentral Denkel LA, Schwab F, Clausmeyer J et al (2023) Central-line associated bloodstream infections in intensive care units before and after implementation of daily antiseptic bathing with chlorhexidine or octenidine: a post-hoc analysis of a cluster-randomised controlled trial. Antimicrob Resist Infect Control 12:55CrossRefPubMedPubMedCentral
14.
go back to reference Derde LP, Dautzenberg MJ, Bonten MJ (2012) Chlorhexidine body washing to control antimicrobial-resistant bacteria in intensive care units: a systematic review. Intensive Care Med 38:931–939CrossRefPubMedPubMedCentral Derde LP, Dautzenberg MJ, Bonten MJ (2012) Chlorhexidine body washing to control antimicrobial-resistant bacteria in intensive care units: a systematic review. Intensive Care Med 38:931–939CrossRefPubMedPubMedCentral
15.
go back to reference Ruiz J, Ramirez P, Villarreal E et al (2017) Daily bathing strategies and cross-transmission of multidrug-resistant organisms: Impact of chlorhexidine-impregnated wipes in a multidrug-resistant gram-negative bacteria endemic intensive care unit. Am J Infect Control 45:1069–1073CrossRefPubMed Ruiz J, Ramirez P, Villarreal E et al (2017) Daily bathing strategies and cross-transmission of multidrug-resistant organisms: Impact of chlorhexidine-impregnated wipes in a multidrug-resistant gram-negative bacteria endemic intensive care unit. Am J Infect Control 45:1069–1073CrossRefPubMed
16.
go back to reference Babiker A, Lutgring JD, Fridkin S et al (2021) Assessing the potential for unintended microbial consequences of routine chlorhexidine bathing for prevention of healthcare-associated infections. Clin Infect Dis 72:891–898CrossRefPubMed Babiker A, Lutgring JD, Fridkin S et al (2021) Assessing the potential for unintended microbial consequences of routine chlorhexidine bathing for prevention of healthcare-associated infections. Clin Infect Dis 72:891–898CrossRefPubMed
Metadata
Title
Decolonization strategies against multidrug resistant organisms in the ICU
Authors
Pedro Póvoa
Paula Ramirez
Stijn Blot
Publication date
18-03-2024
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 4/2024
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-024-07360-4

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