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Intensive Care Medicine
Published in: Intensive Care Medicine 10/2020

01-10-2020 | COVID-19 | Original

Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study

Authors: Jianfeng Xie, Wenjuan Wu, Shusheng Li, Yu Hu, Ming Hu, Jinxiu Li, Yi Yang, Tingrong Huang, Kun Zheng, Yishan Wang, Hanyujie Kang, Yingzi Huang, Li Jiang, Wei Zhang, Ming Zhong, Ling Sang, Xia Zheng, Chun Pan, Ruiqiang Zheng, Xuyan Li, Zhaohui Tong, Haibo Qiu, Bin Du

Published in: Intensive Care Medicine | Issue 10/2020

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Abstract

Purpose

An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality.

Methods

We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors.

Results

Of the 733 patients included in the study, the median (IQR) age was 65 (56–73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high d-dimer level, low PaO2/FiO2 level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19.

Conclusion

In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.
Appendix
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Metadata
Title
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study
Authors
Jianfeng Xie
Wenjuan Wu
Shusheng Li
Yu Hu
Ming Hu
Jinxiu Li
Yi Yang
Tingrong Huang
Kun Zheng
Yishan Wang
Hanyujie Kang
Yingzi Huang
Li Jiang
Wei Zhang
Ming Zhong
Ling Sang
Xia Zheng
Chun Pan
Ruiqiang Zheng
Xuyan Li
Zhaohui Tong
Haibo Qiu
Bin Du
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Keyword
COVID-19
Published in
Intensive Care Medicine / Issue 10/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-020-06211-2

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