Skip to main content
Top
Published in: Intensive Care Medicine 3/2018

Open Access 01-03-2018 | Original

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

Authors: Jean-Louis Vincent, Jean-Yves Lefrant, Katarzyna Kotfis, Rahul Nanchal, Ignacio Martin-Loeches, Xavier Wittebole, Samir G. Sakka, Peter Pickkers, Rui Moreno, Yasser Sakr, on behalf of the ICON and SOAP investigators, SOAP investigators

Published in: Intensive Care Medicine | Issue 3/2018

Login to get access

Abstract

Purpose

To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time.

Methods

We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012.

Results

We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 ± 17.0 vs. 60.6 ± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35–0.59), p < 0.001].

Conclusions

Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis.
Appendix
Available only for authorised users
Literature
1.
go back to reference Kadri SS, Rhee C, Strich JR, Morales MK, Hohmann S, Menchaca J, Suffredini AF, Danner RL, Klompas M (2016) Estimating ten-year trends in septic shock incidence and mortality in United States academic medical centers using clinical data. Chest 151:278–285CrossRefPubMedPubMedCentral Kadri SS, Rhee C, Strich JR, Morales MK, Hohmann S, Menchaca J, Suffredini AF, Danner RL, Klompas M (2016) Estimating ten-year trends in septic shock incidence and mortality in United States academic medical centers using clinical data. Chest 151:278–285CrossRefPubMedPubMedCentral
2.
go back to reference Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R (2014) Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA 311:1308–1316CrossRefPubMed Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R (2014) Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA 311:1308–1316CrossRefPubMed
4.
go back to reference Vincent JL, Mira JP, Antonelli M (2016) Sepsis: older and newer concepts. Lancet Respir Med 4:237–240CrossRefPubMed Vincent JL, Mira JP, Antonelli M (2016) Sepsis: older and newer concepts. Lancet Respir Med 4:237–240CrossRefPubMed
5.
go back to reference Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR et al (2006) Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34:344–353CrossRefPubMed Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR et al (2006) Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34:344–353CrossRefPubMed
6.
go back to reference Vincent JL, Marshall JC, Namendys-Silva SA, Francois B, Martin-Loeches I, Lipman J, Reinhart K, Antonelli M, Pickkers P et al (2014) Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit. Lancet Respir Med 2:380–386CrossRefPubMed Vincent JL, Marshall JC, Namendys-Silva SA, Francois B, Martin-Loeches I, Lipman J, Reinhart K, Antonelli M, Pickkers P et al (2014) Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit. Lancet Respir Med 2:380–386CrossRefPubMed
7.
go back to reference Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957–2963CrossRefPubMed Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957–2963CrossRefPubMed
8.
go back to reference Vincent JL, Moreno R, Takala J, Willatts S, de Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. Intensive Care Med 22:707–710CrossRefPubMed Vincent JL, Moreno R, Takala J, Willatts S, de Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. Intensive Care Med 22:707–710CrossRefPubMed
9.
go back to reference Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:801–810CrossRefPubMedPubMedCentral Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:801–810CrossRefPubMedPubMedCentral
10.
go back to reference Goldstein H (2003) Multilevel statistical models. Hodder Arnold, London Goldstein H (2003) Multilevel statistical models. Hodder Arnold, London
11.
go back to reference Demoule A, Chevret S, Carlucci A, Kouatchet A, Jaber S, Meziani F, Schmidt M, Schnell D, Clergue C et al (2016) Changing use of noninvasive ventilation in critically ill patients: trends over 15 years in francophone countries. Intensive Care Med 42:82–92CrossRefPubMed Demoule A, Chevret S, Carlucci A, Kouatchet A, Jaber S, Meziani F, Schmidt M, Schnell D, Clergue C et al (2016) Changing use of noninvasive ventilation in critically ill patients: trends over 15 years in francophone countries. Intensive Care Med 42:82–92CrossRefPubMed
12.
go back to reference Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E et al (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196CrossRefPubMed Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E et al (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196CrossRefPubMed
13.
go back to reference Sakhuja A, Kumar G, Gupta S, Mittal T, Taneja A, Nanchal RS (2015) Acute kidney injury requiring dialysis in severe sepsis. Am J Respir Crit Care Med 192:951–957CrossRefPubMed Sakhuja A, Kumar G, Gupta S, Mittal T, Taneja A, Nanchal RS (2015) Acute kidney injury requiring dialysis in severe sepsis. Am J Respir Crit Care Med 192:951–957CrossRefPubMed
14.
go back to reference Rhee C, Murphy MV, Li L, Platt R, Klompas M (2015) Comparison of trends in sepsis incidence and coding using administrative claims versus objective clinical data. Clin Infect Dis 60:88–95CrossRefPubMed Rhee C, Murphy MV, Li L, Platt R, Klompas M (2015) Comparison of trends in sepsis incidence and coding using administrative claims versus objective clinical data. Clin Infect Dis 60:88–95CrossRefPubMed
15.
go back to reference Epstein L, Dantes R, Magill S, Fiore A (2016) Varying estimates of sepsis mortality using death certificates and administrative codes—United States, 1999–2014. Morb Mortal Wkly Rep 65:342–345CrossRef Epstein L, Dantes R, Magill S, Fiore A (2016) Varying estimates of sepsis mortality using death certificates and administrative codes—United States, 1999–2014. Morb Mortal Wkly Rep 65:342–345CrossRef
16.
go back to reference Bouza C, Lopez-Cuadrado T, Amate-Blanco JM (2016) Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates. Crit Care 20:313CrossRefPubMedPubMedCentral Bouza C, Lopez-Cuadrado T, Amate-Blanco JM (2016) Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates. Crit Care 20:313CrossRefPubMedPubMedCentral
17.
go back to reference Gohil SK, Cao C, Phelan M, Tjoa T, Rhee C, Platt R, Huang SS (2016) Impact of policies on the rise in sepsis incidence, 2000–2010. Clin Infect Dis 62:695–703CrossRefPubMedPubMedCentral Gohil SK, Cao C, Phelan M, Tjoa T, Rhee C, Platt R, Huang SS (2016) Impact of policies on the rise in sepsis incidence, 2000–2010. Clin Infect Dis 62:695–703CrossRefPubMedPubMedCentral
18.
go back to reference Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL et al (2017) Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009–2014. JAMA 318:1241–1249CrossRefPubMed Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL et al (2017) Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009–2014. JAMA 318:1241–1249CrossRefPubMed
19.
go back to reference Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546–1554CrossRefPubMed Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546–1554CrossRefPubMed
20.
go back to reference Kumar G, Kumar N, Taneja A, Kaleekal T, Tarima S, McGinley E, Jimenez E, Mohan A, Khan RA, Whittle J, Jacobs E, Nanchal R; Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators (2011) Nationwide trends of severe sepsis in the 21st century (2000–2007). Chest 140:1223–1231CrossRefPubMed Kumar G, Kumar N, Taneja A, Kaleekal T, Tarima S, McGinley E, Jimenez E, Mohan A, Khan RA, Whittle J, Jacobs E, Nanchal R; Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators (2011) Nationwide trends of severe sepsis in the 21st century (2000–2007). Chest 140:1223–1231CrossRefPubMed
21.
go back to reference Stoller J, Halpin L, Weis M, Aplin B, Qu W, Georgescu C, Nazzal M (2016) Epidemiology of severe sepsis: 2008–2012. J Crit Care 31:58–62CrossRefPubMed Stoller J, Halpin L, Weis M, Aplin B, Qu W, Georgescu C, Nazzal M (2016) Epidemiology of severe sepsis: 2008–2012. J Crit Care 31:58–62CrossRefPubMed
22.
go back to reference Bouza C, Lopez-Cuadrado T, Saz-Parkinson Z, Amate-Blanco JM (2014) Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006–2011). BMC Infect Dis 14:3863CrossRefPubMedPubMedCentral Bouza C, Lopez-Cuadrado T, Saz-Parkinson Z, Amate-Blanco JM (2014) Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006–2011). BMC Infect Dis 14:3863CrossRefPubMedPubMedCentral
23.
go back to reference The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef
24.
go back to reference Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340:409–417CrossRefPubMed Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340:409–417CrossRefPubMed
25.
go back to reference Baron R, Binder A, Biniek R, Braune S, Buerkle H, Dall P, Demirakca S, Eckardt R, Eggers V et al (2015) Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015)—short version. Ger Med Sci 13:Doc19PubMedPubMedCentral Baron R, Binder A, Biniek R, Braune S, Buerkle H, Dall P, Demirakca S, Eckardt R, Eggers V et al (2015) Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015)—short version. Ger Med Sci 13:Doc19PubMedPubMedCentral
26.
go back to reference Miller RR III, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP (2013) Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med 188:77–82CrossRefPubMedPubMedCentral Miller RR III, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP (2013) Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med 188:77–82CrossRefPubMedPubMedCentral
Metadata
Title
Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)
Authors
Jean-Louis Vincent
Jean-Yves Lefrant
Katarzyna Kotfis
Rahul Nanchal
Ignacio Martin-Loeches
Xavier Wittebole
Samir G. Sakka
Peter Pickkers
Rui Moreno
Yasser Sakr
on behalf of the ICON and SOAP investigators
SOAP investigators
Publication date
01-03-2018
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 3/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-5043-2

Other articles of this Issue 3/2018

Intensive Care Medicine 3/2018 Go to the issue