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01-08-2017 | Original

Potentially modifiable factors contributing to sepsis-associated encephalopathy

Authors: Romain Sonneville, Etienne de Montmollin, Julien Poujade, Maïté Garrouste-Orgeas, Bertrand Souweine, Michael Darmon, Eric Mariotte, Laurent Argaud, François Barbier, Dany Goldgran-Toledano, Guillaume Marcotte, Anne-Sylvie Dumenil, Samir Jamali, Guillaume Lacave, Stéphane Ruckly, Bruno Mourvillier, Jean-François Timsit

Published in: Intensive Care Medicine | Issue 8/2017

Abstract

Purpose

Identifying modifiable factors for sepsis-associated encephalopathy may help improve patient care and outcomes.

Methods

We conducted a retrospective analysis of a prospective multicenter database. Sepsis-associated encephalopathy (SAE) was defined by a score on the Glasgow coma scale (GCS) <15 or when features of delirium were noted. Potentially modifiable risk factors for SAE at ICU admission and its impact on mortality were investigated using multivariate logistic regression analysis and Cox proportional hazard modeling, respectively.

Results

We included 2513 patients with sepsis at ICU admission, of whom 1341 (53%) had sepsis-associated encephalopathy. After adjusting for baseline characteristics, site of infection, and type of admission, the following factors remained independently associated with sepsis-associated encephalopathy: acute renal failure [adjusted odds ratio (aOR) = 1.41, 95% confidence interval (CI) 1.19–1.67], hypoglycemia <3 mmol/l (aOR = 2.66, 95% CI 1.27–5.59), hyperglycemia >10 mmol/l (aOR = 1.37, 95% CI 1.09–1.72), hypercapnia >45 mmHg (aOR = 1.91, 95% CI 1.53–2.38), hypernatremia >145 mmol/l (aOR = 2.30, 95% CI 1.48–3.57), and S. aureus (aOR = 1.54, 95% CI 1.05–2.25). Sepsis-associated encephalopathy was associated with higher mortality, higher use of ICU resources, and longer hospital stay. After adjusting for age, comorbidities, year of admission, and non-neurological SOFA score, even mild alteration of mental status (i.e., a score on the GCS of 13–14) remained independently associated with mortality (adjusted hazard ratio = 1.38, 95% CI 1.09–1.76).

Conclusions

Acute renal failure and common metabolic disturbances represent potentially modifiable factors contributing to sepsis-associated encephalopathy. However, a true causal relationship has yet to be demonstrated. Our study confirms the prognostic significance of mild alteration of mental status in patients with sepsis.

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Title: Potentially modifiable factors contributing to sepsis-associated encephalopathy
Authors: Romain Sonneville
Etienne de Montmollin
Julien Poujade
Maïté Garrouste-Orgeas
Bertrand Souweine
Michael Darmon
Eric Mariotte
Laurent Argaud
François Barbier
Dany Goldgran-Toledano
Guillaume Marcotte
Anne-Sylvie Dumenil
Samir Jamali
Guillaume Lacave
Stéphane Ruckly
Bruno Mourvillier
Jean-François Timsit
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 8/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-017-4807-z

2024 ASCO Annual Meeting

Springer Medicine

Potentially modifiable factors contributing to sepsis-associated encephalopathy

Abstract

Purpose

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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