Published in:
01-11-2016 | Editorial
Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? Yes
Authors:
Rinaldo Bellomo, Giovanni Landoni, Paul Young
Published in:
Intensive Care Medicine
|
Issue 11/2016
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Excerpt
The daily practice of critical care medicine is both personalized and protocolized. For example, in a 24-year-old with severe ARDS, low tidal volume ventilation with permissive hypercapnia would be applied, but not if severe traumatic brain injury and marked intracranial hypertension were also present. In this way, treatment is personalized. In contrast, based on the findings of a large randomized controlled trial (RCT) [
1], in all ICU patients with hyperglycemia, a target of between 8 and 10 mmol/L (144–180 mg/dL) might be prescribed irrespective of other clinical circumstances. In this way, treatment is RCT-based and protocolized. …