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01-03-2016 | Editorial

Lactate-guided resuscitation saves lives: we are not sure

Authors: Jan Bakker, Daniel de Backer, Glenn Hernandez

Published in: Intensive Care Medicine | Issue 3/2016

Excerpt

A fundamental objective of septic shock resuscitation is rapid restoration of tissue perfusion. However, one of the most crucial unresolved challenges is to identify a clinical physiological variable that closely reflects global or regional hypoperfusion, or cellular hypoxia, and thus could be potentially used as an accurate resuscitation target. …

Jansen TC, van Bommel J, Bakker J (2009) Blood lactate monitoring in critically ill patients: a systematic health technology assessment. Crit Care Med 37:2827–2839PubMed

Friedman G, De Backer D, Shahla M, Vincent JL (1998) Oxygen supply dependency can characterize septic shock. Intensive Care Med 24:118–123CrossRef

Bakker J, Nijsten MW, Jansen TC (2013) Clinical use of lactate monitoring in critically ill patients. Ann Intensive Care 3:12CrossRef

Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, Grimaud D (1998) Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 157:1021–1026CrossRef

Revelly JP, Tappy L, Martinez A, Bollmann M, Cayeux MC, Berger MM, Chiolero RL (2005) Lactate and glucose metabolism in severe sepsis and cardiogenic shock. Crit Care Med 33:2235–2240CrossRef

Tapia P, Soto D, Bruhn A, Alegria L, Jarufe N, Luengo C, Kattan E, Regueira T, Meissner A, Menchaca R, Vives MI, Echeverria N, Ospina-Tascon G, Bakker J, Hernandez G (2015) Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care 19:188CrossRef

Hernandez G, Luengo C, Bruhn A, Kattan E, Friedman G, Ospina-Tascon GA, Fuentealba A, Castro R, Regueira T, Romero C, Ince C, Bakker J (2014) When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring. Ann Intensive Care 4:30CrossRef

De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL (2006) The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34:403–408CrossRef

Jansen TC, van Bommel J, Schoonderbeek FJ, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, Willemsen SP, Bakker J (2010) Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 182:752–761CrossRef

10.

Gu WJ, Wang F, Bakker J, Tang L, Liu JC (2014) The effect of goal-directed therapy on mortality in patients with sepsis—earlier is better: a meta-analysis of randomized controlled trials. Crit Care 18:570CrossRef

11.

van Genderen ME, Engels N, van der Valk RJP, Lima A, Klijn E, Bakker J, van Bommel J (2015) Early peripheral perfusion-guided fluid therapy in patients with septic shock. Am J Respir Crit Care Med 191:477–480CrossRef

Title: Lactate-guided resuscitation saves lives: we are not sure
Authors: Jan Bakker
Daniel de Backer
Glenn Hernandez
Publication date: 01-03-2016
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 3/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-016-4220-z

Keynote webinar | Spotlight on medication adherence

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Lactate-guided resuscitation saves lives: we are not sure

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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