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Intensive Care Medicine
Published in: Intensive Care Medicine 3/2016

01-03-2016 | Understanding the Disease

Understanding the role of the cerebrospinal fluid in acid–base disorders

Authors: Thomas Langer, Alberto Zanella, Pietro Caironi

Published in: Intensive Care Medicine | Issue 3/2016

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Excerpt

The importance of acid–base interpretation is witnessed by the bulk of literature constantly being published on the topic [1, 2]. However, none of the recently published papers specifically addresses the acid–base equilibrium of the cerebrospinal fluid (CSF), which is an important compartment, since it influences the activity of the central controllers of respiration. …
Literature
1.
Berend K, de Vries AP, Gans RO (2014) Physiological approach to assessment of acid–base disturbances. N Engl J Med 371:1434–1445CrossRef
2.
Seifter JL (2014) Integration of acid–base and electrolyte disorders. N Engl J Med 371:1821–1831CrossRef
3.
Fencl V, Leith DE (1993) Stewart’s quantitative acid–base chemistry: applications in biology and medicine. Respir Physiol 91:1–16CrossRef
4.
Kazemi H, Johnson DC (1986) Regulation of cerebrospinal fluid acid–base balance. Physiol Rev 66:953–1037CrossRef
5.
Siesjo BK (1972) Symposium on acid–base homeostasis. the regulation of cerebrospinal fluid pH. Kidney Int 1:360–374CrossRef
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Fencl V, Miller TB, Pappenheimer JR (1966) Studies on the respiratory response to disturbances of acid–base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am J Physiol 210:459–472CrossRef
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Leusen IR (1954) Chemosensitivity of the respiratory center influence of changes in the H+ and total buffer concentrations in the cerebral ventricles on respiration. Am J Physiol 176:45–51CrossRef
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Pappenheimer JR, Fencl V, Heisey SR, Held D (1965) Role of cerebral fluids in control of respiration as studied in unanesthetized goats. Am J Physiol 208:436–450CrossRef
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Phillipson EA, Duffin J, Cooper JD (1981) Critical dependence of respiratory rhythmicity on metabolic CO2 load. J Appl Physiol Respir Environ Exerc Physiol 50:45–54PubMed
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Dempsey JA, Forster HV (1982) Mediation of ventilatory adaptations. Physiol Rev 62:262–346CrossRef
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Pierce NF, Fedson DS, Brigham KL, Mitra RC, Sack RB, Mondal A (1970) The ventilatory response to acute base deficit in humans. time course during development and correction of metabolic acidosis. Ann Intern Med 72:633–640CrossRef
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Posner JB, Plum F (1967) Spinal-fluid pH and neurologic symptoms in systemic acidosis. N Engl J Med 277:605–613CrossRef
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Raichle ME, Plum F (1972) Hyperventilation and cerebral blood flow. Stroke 3:566–575CrossRef
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Macdonald RL, Diringer MN, Citerio G (2014) Understanding the disease: aneurysmal subarachnoid hemorrhage. Intensive Care Med 40:1940–1943CrossRef
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Langer T, Scotti E, Carlesso E, Protti A, Zani L, Chierichetti M et al (2015) Electrolyte shifts across the artificial lung in patients on extracorporeal membrane oxygenation: interdependence between partial pressure of carbon dioxide and strong ion difference. J Crit Care 30:2–6CrossRef
Metadata
Title
Understanding the role of the cerebrospinal fluid in acid–base disorders
Authors
Thomas Langer
Alberto Zanella
Pietro Caironi
Publication date
01-03-2016
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 3/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-015-4059-8

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