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01-04-2015 | Understanding the Disease

Understanding organ dysfunction in thrombotic thrombocytopenic purpura

Author: Pier Mannuccio Mannucci

Published in: Intensive Care Medicine | Issue 4/2015

Excerpt

Thrombotic thrombocytopenic purpura (TTP) is the epitome of thrombotic microangiopathies (TMA), i.e., rare multisystem diseases characterized by disseminated microvascular thrombosis leading to ischemic damage and dysfunction in multiple organs [1]. The main clinical syndromes presenting as TMA are, beside TTP, the hemolytic uremic syndrome, disseminated intravascular coagulation, pre-eclampsia, the HELLP syndrome, the catastrophic antiphospholipid antibody syndrome, disseminated malignancy, and heparin-induced thrombocytopenia. …

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Title: Understanding organ dysfunction in thrombotic thrombocytopenic purpura
Author: Pier Mannuccio Mannucci
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 4/2015
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3630-z

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Understanding organ dysfunction in thrombotic thrombocytopenic purpura

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