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Intensive Care Medicine
Published in: Intensive Care Medicine 3/2015

01-03-2015 | Understanding the Disease

Understanding ARDS-associated fibroproliferation

Authors: Gianfranco Umberto Meduri, Mahmoud A. Eltorky

Published in: Intensive Care Medicine | Issue 3/2015

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Excerpt

Understanding ARDS-associated lung fibroproliferation requires viewing (1) ARDS as a disease of multifactorial etiology and not as a syndrome and (2) fibroproliferation as an integral part of the disease process and not as a separate temporal component. Although the term “syndrome” (aggregate of symptoms and signs) was applied in its original description [1], ARDS meets all the constitutive elements of a disease process [2]. Translational clinical research has constructed—through a “holistic” level of inquiry—a pathophysiological model of ARDS that fits the pathogenesis (biology—core stratum) with morphological (histology—intermediate stratum) and clinical (physiology—outer stratum) findings observed during the course of the disease [3]. …
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Metadata
Title
Understanding ARDS-associated fibroproliferation
Authors
Gianfranco Umberto Meduri
Mahmoud A. Eltorky
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 3/2015
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-014-3613-0

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