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01-05-2013 | What's New in Intensive Care

What’s new in glucose control in the ICU?

Author: Greet Van den Berghe

Published in: Intensive Care Medicine | Issue 5/2013

Excerpt

It is 12 years now since the first randomized controlled trial (RCT) showed that targeting strict normoglycemia (80–110 mg/dl in adults) in ICU patients prevented excess morbidity and mortality as compared with tolerating stress hyperglycemia up to 215 mg/dl [1]. Yet, the topic remains as “hot” as ever, reflected by the more than 500 papers published in 2012. …

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10.

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11.

Mesotten D, Gielen M, Sterken C et al (2012) Neurocognitive development of children 4 years after critical illness and treatment with tight glucose control. A randomized controlled trial. JAMA 308:1641–1650PubMedCrossRef

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Tin W, Brunskill G, Kelly T, Fritz S (2012) 15-year follow-up of recurrent “hypoglycemia” in preterm infants. Pediatrics 130:e1497–e1503PubMedCrossRef

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Agus MS, Steil GM, Wypii D et al (2012) Tight glycemic control versus standard care after pediatric cardiac surgery. N Engl J Med 367:1208–1219PubMedCrossRef

14.

Ooi YC, Dagi TF, Maltenfort M et al (2012) Tight glycemic control reduces infection and improves neurological outcome in critically ill neurosurgical and neurological patients. Neurosurgery 71:692–702PubMedCrossRef

15.

Sonneville R, den Hertog HM, Güiza F et al (2012) Impact of hyperglycemia on neuropathological alterations during critical illness. J Clin Endocrinol Metab 97:2113–2123PubMedCrossRef

16.

Preiser JC, Devos P, Ruiz-Santana S et al (2009) A prospective randomised multi-center controlles trial on tight glucose control by intensive insulin therapy in adult intensiev care units: the Glucontrol study. Intensive Care Med 35:1738–1748PubMedCrossRef

Title: What’s new in glucose control in the ICU?
Author: Greet Van den Berghe
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 5/2013
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-013-2874-3

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What’s new in glucose control in the ICU?

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