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Published in: Intensive Care Medicine 1/2013

01-01-2013 | Original

Management of renal replacement therapy in ICU patients: an international survey

Authors: Matthieu Legrand, Michael Darmon, Michael Joannidis, Didier Payen

Published in: Intensive Care Medicine | Issue 1/2013

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Abstract

Purpose

The optimal management of renal replacement therapy (RRT) in critically ill patients remains a matter of debate, although insights have arisen from recent large trials. Nonetheless, little is known about the current practices and beliefs of intensivists. The goal of this study was to record current practices in RRT management among an international panel of intensivists.

Methods

An online questionnaire that included questions about RRT management in critically ill patients with acute kidney injury was sent to European Society of Intensive Care Medicine members in 2010.

Results

Two hundred and seventy-three intensivists from 50 countries responded. The respondents had an average of 12 (7–20) years of experience in ICUs, and most of them worked in mixed ICUs. Most of the intensivists were responsible for prescribing RRT (92.6 %). Half of the respondents reported using both intermittent haemodialysis and continuous renal replacement therapy techniques (CRRT), but most preferred using CRRT. The reasons for preferring CRRT were the perception of better haemodynamic stability, better therapeutic effect resulting from cytokine removal and easier fluid balance control. The intensivists used higher RRT doses in septic patients than in non-septic patients (p = 0.03). Finally, we observed an increasing inclination towards the early use of RRT among the intensivists.

Conclusion

CRRT remains the preferred technique for most intensivists in Europe, and a large proportion of the participating intensivists used RRT prescription doses similar to those proposed a decade ago. Our results provide insights into the motivations of intensivists while presenting the technique that may help in selecting control groups for future trials.
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Literature
1.
go back to reference Joannidis M, Forni LG (2011) Clinical review: timing of renal replacement therapy. Crit Care 15:223PubMedCrossRef Joannidis M, Forni LG (2011) Clinical review: timing of renal replacement therapy. Crit Care 15:223PubMedCrossRef
2.
go back to reference RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S (2009) Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 361:1627–1638PubMedCrossRef RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S (2009) Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 361:1627–1638PubMedCrossRef
3.
go back to reference VA/NIH Acute Renal Failure Trial Network, Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST, Choudhury D, Finkel K, Kellum JA, Paganini E, Schein RM, Smith MW, Swanson KM, Thompson BT, Vijayan A, Watnick S, Star RA, Peduzzi P (2008) Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med 359:7–20PubMedCrossRef VA/NIH Acute Renal Failure Trial Network, Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST, Choudhury D, Finkel K, Kellum JA, Paganini E, Schein RM, Smith MW, Swanson KM, Thompson BT, Vijayan A, Watnick S, Star RA, Peduzzi P (2008) Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med 359:7–20PubMedCrossRef
4.
go back to reference Vinsonneau C, Camus C, Combes A, Costa de Beauregard MA, Klouche K, Boulain T, Pallot JL, Chiche JD, Taupin P, Landais P, Dhainaut JF, Hemodiafe Study Group (2006) Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet 368:379–385PubMedCrossRef Vinsonneau C, Camus C, Combes A, Costa de Beauregard MA, Klouche K, Boulain T, Pallot JL, Chiche JD, Taupin P, Landais P, Dhainaut JF, Hemodiafe Study Group (2006) Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet 368:379–385PubMedCrossRef
5.
go back to reference Payen D, Mateo J, Cavaillon JM, Fraisse F, Floriot C, Vicaut E (2009) Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med 37:803–810PubMedCrossRef Payen D, Mateo J, Cavaillon JM, Fraisse F, Floriot C, Vicaut E (2009) Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med 37:803–810PubMedCrossRef
6.
go back to reference Ricci Z, Ronco C (2011) Timing, dose and mode of dialysis in acute kidney injury. Curr Opin Crit Care 17:556–561PubMedCrossRef Ricci Z, Ronco C (2011) Timing, dose and mode of dialysis in acute kidney injury. Curr Opin Crit Care 17:556–561PubMedCrossRef
7.
go back to reference Ronco C, Zanella M, Brendolan A, Milan M, Canato G, Zamperetti N, Bellomo R (2001) Management of severe acute renal failure in critically ill patients: an international survey in 345 centres. Nephrol Dial Transplant 16:230–237PubMedCrossRef Ronco C, Zanella M, Brendolan A, Milan M, Canato G, Zamperetti N, Bellomo R (2001) Management of severe acute renal failure in critically ill patients: an international survey in 345 centres. Nephrol Dial Transplant 16:230–237PubMedCrossRef
8.
go back to reference Ricci Z, Ronco C, D’Amico G, De Felice R, Rossi S, Bolgan I, Bonello M, Zamperetti N, Petras D, Salvatori G, Dan M, Piccinni P (2006) Practice patterns in the management of acute renal failure in the critically ill patient: an international survey. Nephrol Dial Transplant 21:690–696PubMedCrossRef Ricci Z, Ronco C, D’Amico G, De Felice R, Rossi S, Bolgan I, Bonello M, Zamperetti N, Petras D, Salvatori G, Dan M, Piccinni P (2006) Practice patterns in the management of acute renal failure in the critically ill patient: an international survey. Nephrol Dial Transplant 21:690–696PubMedCrossRef
9.
go back to reference Ricci Z, Picardo S, Ronco C (2007) Results from international questionnaires. Contrib Nephrol 156:297–303PubMedCrossRef Ricci Z, Picardo S, Ronco C (2007) Results from international questionnaires. Contrib Nephrol 156:297–303PubMedCrossRef
10.
go back to reference Ronco C, Ricci Z, Bellomo R (2006) Current worldwide practice of dialysis dose prescription in acute renal failure. Curr Opin Crit Care 12:551–556PubMedCrossRef Ronco C, Ricci Z, Bellomo R (2006) Current worldwide practice of dialysis dose prescription in acute renal failure. Curr Opin Crit Care 12:551–556PubMedCrossRef
11.
go back to reference Schiffl H, Lang SM, Fischer R (2002) Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 346:305–310PubMedCrossRef Schiffl H, Lang SM, Fischer R (2002) Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 346:305–310PubMedCrossRef
12.
go back to reference Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G (2000) Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356:26–30PubMedCrossRef Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G (2000) Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356:26–30PubMedCrossRef
13.
go back to reference Saudan P, Niederberger M, De Seigneux S, Romand J, Pugin J, Perneger T, Martin PY (2006) Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. Kidney Int 70:1312–1317PubMedCrossRef Saudan P, Niederberger M, De Seigneux S, Romand J, Pugin J, Perneger T, Martin PY (2006) Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. Kidney Int 70:1312–1317PubMedCrossRef
14.
go back to reference Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C, Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators, (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294:813–818PubMedCrossRef Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C, Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators, (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294:813–818PubMedCrossRef
15.
go back to reference Uchino S, Bellomo R, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Oudemans-van Straaten H, Ronco C, Kellum JA (2007) Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (BEST kidney) investigators. Intensive Care Med 33:1563–1570PubMedCrossRef Uchino S, Bellomo R, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Oudemans-van Straaten H, Ronco C, Kellum JA (2007) Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (BEST kidney) investigators. Intensive Care Med 33:1563–1570PubMedCrossRef
16.
go back to reference Lins RL, Elseviers MM, Van der Niepen P, Hoste E, Malbrain ML, Damas P, Devriendt J, SHARF investigators, (2009) Intermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial. Nephrol Dial Transplant 24:512–518PubMedCrossRef Lins RL, Elseviers MM, Van der Niepen P, Hoste E, Malbrain ML, Damas P, Devriendt J, SHARF investigators, (2009) Intermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial. Nephrol Dial Transplant 24:512–518PubMedCrossRef
17.
go back to reference Schortgen F, Soubrier N, Delclaux C, Thuong M, Girou E, Brun-Buisson C, Lemaire F, Brochard L (2000) Hemodynamic tolerance of intermittent hemodialysis in critically ill patients: usefulness of practice guidelines. Am J Respir Crit Care Med 162:197–202PubMed Schortgen F, Soubrier N, Delclaux C, Thuong M, Girou E, Brun-Buisson C, Lemaire F, Brochard L (2000) Hemodynamic tolerance of intermittent hemodialysis in critically ill patients: usefulness of practice guidelines. Am J Respir Crit Care Med 162:197–202PubMed
18.
go back to reference Angus DC, Mira J-P, Vincent J-L (2010) Improving clinical trials in the critically ill. Crit Care Med 38:527–532PubMedCrossRef Angus DC, Mira J-P, Vincent J-L (2010) Improving clinical trials in the critically ill. Crit Care Med 38:527–532PubMedCrossRef
19.
go back to reference Bell M, Granath F, Schön S, Ekbom A, Martling C-R (2007) Continuous renal replacement therapy is associated with less chronic renal failure than intermittent haemodialysis after acute renal failure. Intensive Care Med 33:773–780PubMedCrossRef Bell M, Granath F, Schön S, Ekbom A, Martling C-R (2007) Continuous renal replacement therapy is associated with less chronic renal failure than intermittent haemodialysis after acute renal failure. Intensive Care Med 33:773–780PubMedCrossRef
20.
go back to reference Cole L, Bellomo R, Hart G, Journois D, Davenport P, Tipping P, Ronco C (2002) A phase II randomized, controlled trial of continuous hemofiltration in sepsis. Crit Care Med 30:100–106PubMedCrossRef Cole L, Bellomo R, Hart G, Journois D, Davenport P, Tipping P, Ronco C (2002) A phase II randomized, controlled trial of continuous hemofiltration in sepsis. Crit Care Med 30:100–106PubMedCrossRef
21.
go back to reference Joannidis M (2009) Continuous renal replacement therapy in sepsis and multisystem organ failure. Semin Dial 2:160–164CrossRef Joannidis M (2009) Continuous renal replacement therapy in sepsis and multisystem organ failure. Semin Dial 2:160–164CrossRef
22.
go back to reference Lombel RM, Kommareddi M, Mottes T, Selewski DT, Han YY, Gipson DS, Collins KL, Heung M (2012) Implications of different fluid overload definitions in pediatric stem cell transplant patients requiring continuous renal replacement therapy. Intensive Care Med 38:663–669PubMedCrossRef Lombel RM, Kommareddi M, Mottes T, Selewski DT, Han YY, Gipson DS, Collins KL, Heung M (2012) Implications of different fluid overload definitions in pediatric stem cell transplant patients requiring continuous renal replacement therapy. Intensive Care Med 38:663–669PubMedCrossRef
23.
go back to reference Karvellas CJ, Farhat MR, Sajjad I, Mogensen SS, Leung AA, Wald R, Bagshaw SM (2011) A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis. Crit Care 15:R72PubMedCrossRef Karvellas CJ, Farhat MR, Sajjad I, Mogensen SS, Leung AA, Wald R, Bagshaw SM (2011) A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis. Crit Care 15:R72PubMedCrossRef
24.
go back to reference Csomos A, Varga S, Bertolini G, Hibbert C, Sandor J, Capuzzo M, Guidet BR (2010) Intensive care reimbursement practices: results from the ICUFUND survey. Intensive Care Med 36:1759–1764PubMedCrossRef Csomos A, Varga S, Bertolini G, Hibbert C, Sandor J, Capuzzo M, Guidet BR (2010) Intensive care reimbursement practices: results from the ICUFUND survey. Intensive Care Med 36:1759–1764PubMedCrossRef
25.
go back to reference Cannesson M, Pestel G, Ricks C, Hoeft A, Perel A (2011) Crit Care Hemodynamic monitoring and management in patients undergoing high risk surgery: a survey among north American and European anesthesiologists. Crit Care 15:R197PubMedCrossRef Cannesson M, Pestel G, Ricks C, Hoeft A, Perel A (2011) Crit Care Hemodynamic monitoring and management in patients undergoing high risk surgery: a survey among north American and European anesthesiologists. Crit Care 15:R197PubMedCrossRef
26.
go back to reference Beloucif S, Payen D (1998) A European survey of the use of inhaled nitric oxide in the ICU. Working group on inhaled NO in the ICU of the European Society of Intensive Care Medicine. Intensive Care Med 24:864–877PubMedCrossRef Beloucif S, Payen D (1998) A European survey of the use of inhaled nitric oxide in the ICU. Working group on inhaled NO in the ICU of the European Society of Intensive Care Medicine. Intensive Care Med 24:864–877PubMedCrossRef
Metadata
Title
Management of renal replacement therapy in ICU patients: an international survey
Authors
Matthieu Legrand
Michael Darmon
Michael Joannidis
Didier Payen
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 1/2013
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2706-x

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