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Intensive Care Medicine
Published in: Intensive Care Medicine 11/2011

01-11-2011 | Pediatric Original

Variability in usual care mechanical ventilation for pediatric acute lung injury: the potential benefit of a lung protective computer protocol

Authors: Robinder G. Khemani, Katherine Sward, Alan Morris, J. Michael Dean, Christopher J. L. Newth, On behalf of the NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN)

Published in: Intensive Care Medicine | Issue 11/2011

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Abstract

Purpose

Although pediatric intensivists claim to embrace lung protective ventilation for acute lung injury (ALI), ventilator management is variable. We describe ventilator changes clinicians made for children with hypoxemic respiratory failure, and evaluate the potential acceptability of a pediatric ventilation protocol.

Methods

This was a retrospective cohort study performed in a tertiary care pediatric intensive care unit (PICU). The study period was from January 2000 to July 2007. We included mechanically ventilated children with PaO2/FiO2 (P/F) ratio less than 300. We assessed variability in ventilator management by evaluating actual changes to ventilator settings after an arterial blood gas (ABG). We evaluated the potential acceptability of a pediatric mechanical ventilation protocol we adapted from National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) Acute Respiratory Distress Syndrome (ARDS) Network protocols by comparing actual practice changes in ventilator settings to changes that would have been recommended by the protocol.

Results

A total of 2,719 ABGs from 402 patients were associated with 6,017 ventilator settings. Clinicians infrequently decreased FiO2, even when the PaO2 was high (>68 mmHg). The protocol would have recommended more positive end expiratory pressure (PEEP) than was used in actual practice 42% of the time in the mid PaO2 range (55–68 mmHg) and 67% of the time in the low PaO2 range (<55 mmHg). Clinicians often made no change to either peak inspiratory pressure (PIP) or ventilator rate (VR) when the protocol would have recommended a change, even when the pH was greater than 7.45 with PIP at least 35 cmH2O.

Conclusions

There may be lost opportunities to minimize potentially injurious ventilator settings for children with ALI. A reproducible pediatric mechanical ventilation protocol could prompt clinicians to make ventilator changes that are consistent with lung protective ventilation.
Appendix
Available only for authorised users
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Metadata
Title
Variability in usual care mechanical ventilation for pediatric acute lung injury: the potential benefit of a lung protective computer protocol
Authors
Robinder G. Khemani
Katherine Sward
Alan Morris
J. Michael Dean
Christopher J. L. Newth
On behalf of the NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN)
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 11/2011
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-011-2367-1

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