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01-07-2009 | Original

Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients

Authors: Maurizio Migliari, Giacomo Bellani, Roberto Rona, Stefano Isgrò, Beatrice Vergnano, Tommaso Mauri, Nicolò Patroniti, Antonio Pesenti, Giuseppe Foti

Published in: Intensive Care Medicine | Issue 7/2009

Abstract

Purpose

Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil.

Methods

Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe₁, ProRe₂), with the same sedation targets.

Results

With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe₁: respectively, 3.3 ± 3.0 versus 8.9 ± 6.1 and 7.47 ± 5.05 versus 16.3 ± 11.4 min. During SevAn the PaCO₂ and minute ventilation increased. Hemodynamics was stable between ProRe₁ and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits.

Conclusions

Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions.

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Title: Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients
Authors: Maurizio Migliari
Giacomo Bellani
Roberto Rona
Stefano Isgrò
Beatrice Vergnano
Tommaso Mauri
Nicolò Patroniti
Antonio Pesenti
Giuseppe Foti
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 7/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-009-1414-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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