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Intensive Care Medicine

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01-01-2009 | Pediatric Original

Regional and overall ventilation inhomogeneities in preterm and term-born infants

Authors: Thomas Riedel, Manuela Kyburz, Philipp Latzin, Cindy Thamrin, Urs Frey

Published in: Intensive Care Medicine | Issue 1/2009

Abstract

Objectives

We compared ventilation inhomogeneity assessed by electrical impedance tomography (EIT) and multiple breath washout (MBW) in preterm and term-born infants. We hypothesised that EIT measurements in spontaneously breathing infants are repeatable and that differences in regional ventilation distribution measured by EIT can distinguish between preterm and term-born infants.

Design

Cross-sectional group comparison study.

Setting

Lung function laboratory at a University Children’s Hospital.

Participants

Seventeen healthy term-born and 15 preterm infants at a matched postmenstrual age of 44 weeks.

Measurements and results

We concurrently measured ventilation inhomogeneity by EIT, ventilation inhomogeneity (LCI) and functional residual capacity (FRC) by MBW and tidal breathing variables during unsedated quiet sleep. EIT measurements were highly repeatable (coefficient of variation 3.6%). Preterm infants showed significantly more ventilation of the independent parts of the lungs compared to healthy term-born infants assessed by EIT (mean difference 5.0, 95 CI 1.3–8%). Whereas the two groups showed no differences in lung volumes or ventilation inhomogeneities assessed by MBW, EIT discriminated better between term and preterm infants. (FRC/kg: mean difference 1.1 mL, 95% CI −1.4–3.8 mL; LCI: mean difference 0.03, 95% CI −0.32–0.25).

Conclusions

EIT shows distinct differences in ventilation distribution between preterm and term-born infants, which cannot be detected by MBW. Although preterm infants are capable of dynamically maintaining overall functional residual volume and ventilation distribution, they show some spatial differences from fullterm infants.

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Title: Regional and overall ventilation inhomogeneities in preterm and term-born infants
Authors: Thomas Riedel
Manuela Kyburz
Philipp Latzin
Cindy Thamrin
Urs Frey
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 1/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1299-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Regional and overall ventilation inhomogeneities in preterm and term-born infants

Abstract

Objectives

Design

Setting

Participants

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Design

Setting

Participants

Measurements and results

Conclusions

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