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Published in:

01-12-2008 | Original

Serum levels of osteopontin are increased in SIRS and sepsis

Authors: Rosanna Vaschetto, Stefania Nicola, Carlo Olivieri, Elena Boggio, Fabio Piccolella, Riccardo Mesturini, Federica Damnotti, Davide Colombo, Paolo Navalesi, Francesco Della Corte, Umberto Dianzani, Annalisa Chiocchetti

Published in: Intensive Care Medicine | Issue 12/2008

Abstract

Objective

In sepsis, dysregulation of the immune response leads to rapid multiorgan failure and death. Accurate and timely diagnosis is lifesaving and should discriminate sepsis from the systemic inflammatory response syndrome (SIRS) caused by non-infectious agents. Osteopontin acts as an extracellular matrix component or a soluble cytokine in inflamed tissues. Its exact role in immune response and sepsis remains to be elucidated. Therefore, we investigated the role of osteopontin in SIRS and sepsis.

Design

Prospective, observational study.

Setting

Intensive care unit of a university hospital.

Patients and participants

Fifty-six patients with SIRS or sepsis and 56 healthy subjects were enrolled.

Interventions

We analyzed the serum levels of osteopontin and TH1–TH2 cytokines and investigated the role of osteopontin on interleukin 6 secretion by monocytes.

Measurements and main results

Serum osteopontin levels were strikingly higher in patients than in controls and in sepsis than in SIRS, and decreased during the resolution of both the disorders. Receiver operating characteristic curves showed that osteopontin levels have discriminative power between SIRS and sepsis with an area under the curve of 0.796. Osteopontin levels directly correlated with those of interleukin 6 and in vitro, recombinant osteopontin increased interleukin 6 secretion by monocytes in both the absence and presence of high doses of lipopolysaccharide.

Conclusion

These data suggest that osteopontin might be a mediator involved in the pathogenesis of SIRS and sepsis, possibly by supporting interleukin 6 secretion.

Descriptor

45. SIRS/Sepsis: clinical studies.

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Title: Serum levels of osteopontin are increased in SIRS and sepsis
Authors: Rosanna Vaschetto
Stefania Nicola
Carlo Olivieri
Elena Boggio
Fabio Piccolella
Riccardo Mesturini
Federica Damnotti
Davide Colombo
Paolo Navalesi
Francesco Della Corte
Umberto Dianzani
Annalisa Chiocchetti
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 12/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1268-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serum levels of osteopontin are increased in SIRS and sepsis

Abstract

Objective

Design

Setting

Patients and participants

Interventions

Measurements and main results

Conclusion

Descriptor

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients and participants

Interventions

Measurements and main results

Conclusion

Descriptor

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