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01-11-2008 | Original

Impact of obesity in mechanically ventilated patients: a prospective study

Authors: Jean-Pierre Frat, Valérie Gissot, Stéphanie Ragot, Arnaud Desachy, Isabelle Runge, Christine Lebert, René Robert, for the Association des Réanimateurs du Centre-Ouest (ARCO) study group

Published in: Intensive Care Medicine | Issue 11/2008

Abstract

Objective

To analyze the influence of severe obesity on mortality and morbidity in mechanically ventilated intensive care unit (ICU) patients.

Design

Prospective, multi-center exposed/unexposed matched epidemiologic study.

Setting

Hospital setting.

Patients

Severely obese patients (body mass index (BMI) ≥ 35 kg/m²), mechanically ventilated for at least 2 days were matched with unexposed nonobese patients (BMI < 30 kg/m²) for center, gender, age (±5 years), and the simplified acute physiology (SAPS) II score (±5 points). We recorded tracheal intubation, catheter placement, nosocomial infections, development of pressure ulcers, ICU and hospital outcome.

Results

Eighty-two severely obese patients (mean BMI, 42 ± 6 kg/m²) were compared to 124 nonobese patients (mean BMI, 24 ± 4 kg/m²). The ICU course was similar in both the groups, except for the difficulties during tracheal intubation (15 vs. 6%) and post-extubation stridor (15% vs. 3%), which were significantly more frequent in obese patients (P < 0.05). The ICU mortality rate did not differ between obese and nonobese patients (24 and 25%, respectively); nor did the risk-adjusted hospital mortality rate (0.76, 95% confidence interval 0.41–1.16 in obese patients versus 0.82, 95% confidence interval 0.54–1.13 in nonobese patients). Conditional logistic regression confirmed that mortality was not associated with obesity.

Conclusion

The only difference in morbidity of obese patients who were mechanically ventilated was increased difficulty with tracheal intubation and a higher frequency of post-extubation stridor. Obesity was not associated either with increased ICU mortality or with hospital mortality.

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Title: Impact of obesity in mechanically ventilated patients: a prospective study
Authors: Jean-Pierre Frat
Valérie Gissot
Stéphanie Ragot
Arnaud Desachy
Isabelle Runge
Christine Lebert
René Robert
for the Association des Réanimateurs du Centre-Ouest (ARCO) study group
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 11/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1245-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of obesity in mechanically ventilated patients: a prospective study

Abstract

Objective

Design

Setting

Patients

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients

Results

Conclusion

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